EIF3D

EIF3D
Identifiers
Aliases	EIF3D,EIF3S7, eIF3-p66, eIF3-zeta, eukaryotic translation initiation factor 3 subunit D
External IDs	OMIM:603915;MGI:1933181;HomoloGene:2782;GeneCards:EIF3D;OMA:EIF3D - orthologs
Gene location (Human) Chr. Chromosome 22 (human) Band 22q12.3 Start 36,510,855bp End 36,529,184bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15|15 E1 Start 77,843,198bp End 77,855,013bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in body of pancreas left ovary skin of abdomen skin of leg epithelium of nasopharynx parotid gland right uterine tube right ovary spleen body of stomach Top expressed in epiblast mandibular prominence somite abdominal wall maxillary prominence fetal liver hematopoietic progenitor cell human fetus efferent ductule endothelial cell of lymphatic vessel ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding translation initiation factor activity RNA binding mRNA cap binding Cellular component cytoplasm cytosol eukaryotic translation initiation factor 3 complex, eIF3m membrane eukaryotic translation initiation factor 3 complex eukaryotic 43S preinitiation complex eukaryotic 48S preinitiation complex Biological process formation of cytoplasmic translation initiation complex viral translational termination-reinitiation translational initiation protein biosynthesis IRES-dependent viral translational initiation cap-dependent translational initiation positive regulation of translation positive regulation of mRNA binding cytoplasmic translational initiation Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 8664 55944 Ensembl ENSG00000100353 ENSMUSG00000016554 UniProt O15371 O70194 RefSeq (mRNA) NM_003753 NM_018749 RefSeq (protein) NP_003744 NP_061219 Location (UCSC) Chr 22: 36.51 – 36.53 Mb Chr 15: 77.84 – 77.86 Mb PubMedsearch
Wikidata
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Eukaryotic translation initiation factor 3 subunit D(eIF3d) is aproteinthat in humans is encoded by theEIF3Dgene.

Function

Eukaryotic translation initiation factor-3 (eIF3), the largest of theeIFs,is amultiprotein complexcomposed of at least ten nonidentical subunits. The complex binds to the40S ribosomeand helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with theternary complexof eIF2/GTP/methionyl-tRNA, and by promotingmRNAbinding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.

Interactions

EIF3D has been shown tointeractwithPHLDA1andEIF3A.

EIF3D has also been shown to interact withc-JunmRNA via a non-canonical mechanism. Instead of the EIF4G protein acting as a cap-binding protein to mediate translation, EIF3D has been shown to be a cap binding protein for certain mRNAs such asc-Junwhich has structures at the 5' UTR inhibiting binding of EIF4G and promoting binding of EIF3D.EIF3D as a cap binding protein has been thought of as critical to regulating gene expression under cell stress such as during glucose deprivation. For translation ofc-Jununder glucose starved conditions, the cap binding activity of EIF3D increased by 10-fold.

See also

• Eukaryotic initiation factor 3 (eIF3)

Further reading

• Asano K, Kinzy TG, Merrick WC, Hershey JW (January 1997)."Conservation and diversity of eukaryotic translation initiation factor eIF3".The Journal of Biological Chemistry.272(2): 1101–1109.doi:10.1074/jbc.272.2.1101.PMID8995409.
• Méthot N, Rom E, Olsen H, Sonenberg N (January 1997)."The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170".The Journal of Biological Chemistry.272(2): 1110–1116.doi:10.1074/jbc.272.2.1110.PMID8995410.
• Block KL, Vornlocher HP, Hershey JW (November 1998)."Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3".The Journal of Biological Chemistry.273(48): 31901–31908.doi:10.1074/jbc.273.48.31901.PMID9822659.
• Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999)."The DNA sequence of human chromosome 22".Nature.402(6761): 489–495.Bibcode:1999Natur.402..489D.doi:10.1038/990031.PMID10591208.
• Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, et al. (May 2001)."Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation".The EMBO Journal.20(9): 2326–2337.doi:10.1093/emboj/20.9.2326.PMC125443.PMID11331597.
• Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product".Cellular Signalling.13(5): 345–352.doi:10.1016/S0898-6568(01)00141-3.PMID11369516.
• Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P (December 2001)."The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3".The Journal of Biological Chemistry.276(49): 45988–45995.doi:10.1074/jbc.M104966200.PMID11590142.
• Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003)."Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3".European Journal of Biochemistry.270(20): 4133–4139.doi:10.1046/j.1432-1033.2003.03807.x.PMID14519125.
• Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004)."A genome annotation-driven approach to cloning the human ORFeome".Genome Biology.5(10): R84.doi:10.1186/gb-2004-5-10-r84.PMC545604.PMID15461802.
• Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nature Biotechnology.23(1): 94–101.doi:10.1038/nbt1046.PMID15592455.S2CID7200157.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Molecular Systems Biology.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.