EIF3D
Eukaryotic translation initiation factor 3 subunit D(eIF3d) is aproteinthat in humans is encoded by theEIF3Dgene.[5][6]
Function
[edit]Eukaryotic translation initiation factor-3 (eIF3), the largest of theeIFs,is amultiprotein complexcomposed of at least ten nonidentical subunits. The complex binds to the40S ribosomeand helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with theternary complexof eIF2/GTP/methionyl-tRNA, and by promotingmRNAbinding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex.[6]
Interactions
[edit]EIF3D has been shown tointeractwithPHLDA1[7]andEIF3A.[8][9][10]
EIF3D has also been shown to interact withc-JunmRNA via a non-canonical mechanism. Instead of the EIF4G protein acting as a cap-binding protein to mediate translation, EIF3D has been shown to be a cap binding protein for certain mRNAs such asc-Junwhich has structures at the 5' UTR inhibiting binding of EIF4G and promoting binding of EIF3D.[11]EIF3D as a cap binding protein has been thought of as critical to regulating gene expression under cell stress such as during glucose deprivation. For translation ofc-Jununder glucose starved conditions, the cap binding activity of EIF3D increased by 10-fold.[12][13]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000100353–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000016554–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Asano K, Vornlocher HP, Richter-Cook NJ, Merrick WC, Hinnebusch AG, Hershey JW (October 1997)."Structure of cDNAs encoding human eukaryotic initiation factor 3 subunits. Possible roles in RNA binding and macromolecular assembly".The Journal of Biological Chemistry.272(43): 27042–27052.doi:10.1074/jbc.272.43.27042.PMID9341143.
- ^ab"Entrez Gene: EIF3S7 eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67kDa".
- ^Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product".Cellular Signalling.13(5): 345–352.doi:10.1016/S0898-6568(01)00141-3.PMID11369516.
- ^Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Molecular Systems Biology.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.
- ^Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003)."Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3".European Journal of Biochemistry.270(20): 4133–4139.doi:10.1046/j.1432-1033.2003.03807.x.PMID14519125.
- ^Block KL, Vornlocher HP, Hershey JW (November 1998)."Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3".The Journal of Biological Chemistry.273(48): 31901–31908.doi:10.1074/jbc.273.48.31901.PMID9822659.
- ^Lee AS, Kranzusch PJ, Doudna JA, Cate JH (August 2016)."eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation".Nature.536(7614): 96–99.Bibcode:2016Natur.536...96L.doi:10.1038/nature18954.PMC5003174.PMID27462815.
- ^Jia L, Qian SB (January 2021)."A Versatile eIF3d in Translational Control of Stress Adaptation".Molecular Cell.81(1): 10–12.doi:10.1016/j.molcel.2020.12.016.PMID33417853.S2CID231303797.
- ^Lamper AM, Fleming RH, Ladd KM, Lee AS (November 2020). "A phosphorylation-regulated eIF3d translation switch mediates cellular adaptation to metabolic stress".Science.370(6518): 853–856.Bibcode:2020Sci...370..853L.doi:10.1126/science.abb0993.PMID33184215.S2CID226308112.
Further reading
[edit]- Asano K, Kinzy TG, Merrick WC, Hershey JW (January 1997)."Conservation and diversity of eukaryotic translation initiation factor eIF3".The Journal of Biological Chemistry.272(2): 1101–1109.doi:10.1074/jbc.272.2.1101.PMID8995409.
- Méthot N, Rom E, Olsen H, Sonenberg N (January 1997)."The human homologue of the yeast Prt1 protein is an integral part of the eukaryotic initiation factor 3 complex and interacts with p170".The Journal of Biological Chemistry.272(2): 1110–1116.doi:10.1074/jbc.272.2.1110.PMID8995410.
- Block KL, Vornlocher HP, Hershey JW (November 1998)."Characterization of cDNAs encoding the p44 and p35 subunits of human translation initiation factor eIF3".The Journal of Biological Chemistry.273(48): 31901–31908.doi:10.1074/jbc.273.48.31901.PMID9822659.
- Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, et al. (December 1999)."The DNA sequence of human chromosome 22".Nature.402(6761): 489–495.Bibcode:1999Natur.402..489D.doi:10.1038/990031.PMID10591208.
- Asano K, Shalev A, Phan L, Nielsen K, Clayton J, Valásek L, et al. (May 2001)."Multiple roles for the C-terminal domain of eIF5 in translation initiation complex assembly and GTPase activation".The EMBO Journal.20(9): 2326–2337.doi:10.1093/emboj/20.9.2326.PMC125443.PMID11331597.
- Hinz T, Flindt S, Marx A, Janssen O, Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product".Cellular Signalling.13(5): 345–352.doi:10.1016/S0898-6568(01)00141-3.PMID11369516.
- Morris-Desbois C, Réty S, Ferro M, Garin J, Jalinot P (December 2001)."The human protein HSPC021 interacts with Int-6 and is associated with eukaryotic translation initiation factor 3".The Journal of Biological Chemistry.276(49): 45988–45995.doi:10.1074/jbc.M104966200.PMID11590142.
- Mayeur GL, Fraser CS, Peiretti F, Block KL, Hershey JW (October 2003)."Characterization of eIF3k: a newly discovered subunit of mammalian translation initiation factor elF3".European Journal of Biochemistry.270(20): 4133–4139.doi:10.1046/j.1432-1033.2003.03807.x.PMID14519125.
- Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004)."A genome annotation-driven approach to cloning the human ORFeome".Genome Biology.5(10): R84.doi:10.1186/gb-2004-5-10-r84.PMC545604.PMID15461802.
- Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, et al. (January 2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells".Nature Biotechnology.23(1): 94–101.doi:10.1038/nbt1046.PMID15592455.S2CID7200157.
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007)."Large-scale mapping of human protein-protein interactions by mass spectrometry".Molecular Systems Biology.3(1): 89.doi:10.1038/msb4100134.PMC1847948.PMID17353931.