EMR3

ADGRE3
Identifiers
Aliases	ADGRE3,EMR3, adhesion G protein-coupled receptor E3
External IDs	OMIM:606101;HomoloGene:50009;GeneCards:ADGRE3;OMA:ADGRE3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	14,690,027bp
RNA expressionpattern
	Top expressed in
	blood; ; monocyte; ; granulocyte; ; gonad; ; appendix; ; bone marrow; ; bone marrow cells; ; spleen; ; right lung; ; gallbladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; extracellular region; membrane; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane; integral component of plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; signal transduction; neutrophil degranulation; adenylate cyclase-activating G protein-coupled receptor signaling pathway;
	Sources:Amigo/QuickGO
Orthologs
	84658
	n/a
	ENSG00000131355
	n/a
	Q9BY15
	n/a
	NM_001289158; NM_001289159; NM_032571; NM_152939
	n/a
	NP_001276087; NP_001276088; NP_115960
	n/a
	Wikidata
View/Edit Human

EGF-like module-containing mucin-like hormone receptor-like 3is aproteinencoded by theADGRE3gene.^[3]^[4]EMR3 is a member of theadhesion GPCRfamily.^[5]^[6] Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing(GAIN)domain.^[7]

EMR3 expression is restricted to monocytes/macrophages, myeloid dendritic cells, and mature granulocytes in human.^[8]Transcription of the EMR3 gene results in two alternative spliced forms: a surface protein with extracellular, 7TM, and intracellular domains as well as a truncated soluble form of only the extracellular domain.^[9]Mice, next to Emr2, lack the Emr3 gene.^[10]

Function

The protein may play a role inmyeloid-myeloid interactions during immune and inflammatory responses.^[11]

Ligands

A potential ligand of EMR3 likely is expressed on human macrophage and activated neutrophils.^[9]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000131355–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001)."Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils".The Journal of Biological Chemistry.276(22): 18863–70.doi:10.1074/jbc.M101147200.PMID 11279179.
^Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015)."International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors".Pharmacological Reviews.67(2): 338–67.doi:10.1124/pr.114.009647.PMC4394687.PMID 25713288.
^Stacey M, Yona S (2011).Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology).Berlin: Springer.ISBN 978-1-4419-7912-4.
^Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage".Science Signaling.6(276): re3.doi:10.1126/scisignal.2003825.PMID 23695165.S2CID 6958640.
^Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012)."A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis".The EMBO Journal.31(6): 1364–78.doi:10.1038/emboj.2012.26.PMC3321182.PMID 22333914.
^Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007)."The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes".Journal of Leukocyte Biology.81(2): 440–8.doi:10.1189/jlb.0406276.PMID 17108056.S2CID 37679823.
^^a ^bStacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001)."Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils".The Journal of Biological Chemistry.276(22): 18863–70.doi:10.1074/jbc.M101147200.PMID 11279179.
^Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006)."An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2".FASEB Journal.20(14): 2582–4.doi:10.1096/fj.06-6500fje.PMID 17068111.S2CID 16254868.
^"Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".

External links

GPCR consortium

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131355–Ensembl,May 2017

[2] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11279179-3] Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001)."Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils".The Journal of Biological Chemistry.276(22): 18863–70.doi:10.1074/jbc.M101147200.PMID 11279179.

[4] Hamann, J; Aust, G; Araç, D; Engel, FB; Formstone, C; Fredriksson, R; Hall, RA; Harty, BL; Kirchhoff, C; Knapp, B; Krishnan, A; Liebscher, I; Lin, HH; Martinelli, DC; Monk, KR; Peeters, MC; Piao, X; Prömel, S; Schöneberg, T; Schwartz, TW; Singer, K; Stacey, M; Ushkaryov, YA; Vallon, M; Wolfrum, U; Wright, MW; Xu, L; Langenhan, T; Schiöth, HB (April 2015)."International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G protein-coupled receptors".Pharmacological Reviews.67(2): 338–67.doi:10.1124/pr.114.009647.PMC4394687.PMID 25713288.

[isbn1-4419-7912-3-5] Stacey M, Yona S (2011).Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology).Berlin: Springer.ISBN 978-1-4419-7912-4.

[6] Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage".Science Signaling.6(276): re3.doi:10.1126/scisignal.2003825.PMID 23695165.S2CID 6958640.

[pmid22333914-7] Araç D, Boucard AA, Bolliger MF, Nguyen J, Soltis SM, Südhof TC, Brunger AT (Mar 2012)."A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis".The EMBO Journal.31(6): 1364–78.doi:10.1038/emboj.2012.26.PMC3321182.PMID 22333914.

[8] Matmati M, Pouwels W, van Bruggen R, Jansen M, Hoek RM, Verhoeven AJ, Hamann J (Feb 2007)."The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes".Journal of Leukocyte Biology.81(2): 440–8.doi:10.1189/jlb.0406276.PMID 17108056.S2CID 37679823.

[ReferenceA-9] Stacey M, Lin HH, Hilyard KL, Gordon S, McKnight AJ (Jun 2001)."Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils".The Journal of Biological Chemistry.276(22): 18863–70.doi:10.1074/jbc.M101147200.PMID 11279179.

[10] Kwakkenbos MJ, Matmati M, Madsen O, Pouwels W, Wang Y, Bontrop RE, Heidt PJ, Hoek RM, Hamann J (Dec 2006)."An unusual mode of concerted evolution of the EGF-TM7 receptor chimera EMR2".FASEB Journal.20(14): 2582–4.doi:10.1096/fj.06-6500fje.PMID 17068111.S2CID 16254868.

[entrez-11] "Entrez Gene: EMR3 egf-like module containing, mucin-like, hormone receptor-like 3".

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