F2RL3

F2RL3
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 2ZPK,3QDZ
Identifiers
Aliases	F2RL3,PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDs	OMIM:602779;MGI:1298207;HomoloGene:36148;GeneCards:F2RL3;OMA:F2RL3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 16,888,999bp End 16,892,606bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 35.08 cM|8 B3.3 Start 73,488,508bp End 73,490,502bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in right lung upper lobe of left lung left lobe of thyroid gland subcutaneous adipose tissue islet of Langerhans right lobe of thyroid gland lactiferous gland monocyte body of stomach transverse colon Top expressed in left lobe of liver right lobe of liver vasculature vasculature of organ choroid plexus embryo spleen yolk sac quadriceps femoris muscle placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thrombin-activated receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process platelet activation hemostasis phospholipase C-activating G protein-coupled receptor signaling pathway thrombin-activated receptor signaling pathway positive regulation of release of sequestered calcium ion into cytosol platelet dense granule organization response to wounding signal transduction blood coagulation positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 9002 14065 Ensembl ENSG00000127533 ENSMUSG00000050147 UniProt Q96RI0 O88634 RefSeq (mRNA) NM_003950 NM_007975 RefSeq (protein) NP_003941 NP_032001 Location (UCSC) Chr 19: 16.89 – 16.89 Mb Chr 8: 73.49 – 73.49 Mb PubMedsearch
Wikidata
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Protease-activated receptor 4(PAR-4), also known ascoagulation factor II (thrombin) receptor-like 3,is aproteinthat in humans is encoded by theF2RL3gene.

Function

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of theprotease-activated receptorfamily. F2RL3 is activated by proteolytic cleavage of its extracellularamino terminus.The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated bythrombinandtrypsin.

See also

• Protease-activated receptor

Further reading

• Leger AJ, Covic L, Kuliopulos A (2006)."Protease-activated receptors in cardiovascular diseases".Circulation.114(10): 1070–7.doi:10.1161/CIRCULATIONAHA.105.574830.PMID16952995.S2CID312800.
• Xu WF, Andersen H, Whitmore TE, et al. (1998)."Cloning and characterization of human protease-activated receptor 4".Proc. Natl. Acad. Sci. U.S.A.95(12): 6642–6.Bibcode:1998PNAS...95.6642X.doi:10.1073/pnas.95.12.6642.PMC22580.PMID9618465.
• Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation".Nature.394(6694): 690–4.Bibcode:1998Natur.394..690K.doi:10.1038/29325.PMID9716134.S2CID4408582.
• Kahn ML, Hammes SR, Botka C, Coughlin SR (1998)."Gene and locus structure and chromosomal localization of the protease-activated receptor gene family".J. Biol. Chem.273(36): 23290–6.doi:10.1074/jbc.273.36.23290.PMID9722561.S2CID32777201.
• Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999)."Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin".J. Clin. Invest.103(6): 879–87.doi:10.1172/JCI6042.PMC408153.PMID10079109.
• Andersen H, Greenberg DL, Fujikawa K, et al. (1999)."Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity".Proc. Natl. Acad. Sci. U.S.A.96(20): 11189–93.Bibcode:1999PNAS...9611189A.doi:10.1073/pnas.96.20.11189.PMC18009.PMID10500152.
• Sambrano GR, Huang W, Faruqi T, et al. (2000)."Cathepsin G activates protease-activated receptor-4 in human platelets".J. Biol. Chem.275(10): 6819–23.doi:10.1074/jbc.275.10.6819.PMID10702240.S2CID33219053.
• Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin".Nature.404(6778): 609–13.Bibcode:2000Natur.404..609N.doi:10.1038/35007085.PMID10766244.S2CID4410800.
• Miike S, McWilliam AS, Kita H (2002)."Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2".J. Immunol.167(11): 6615–22.doi:10.4049/jimmunol.167.11.6615.PMID11714832.S2CID9302877.
• Asokananthan N, Graham PT, Fink J, et al. (2002)."Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells".J. Immunol.168(7): 3577–85.doi:10.4049/jimmunol.168.7.3577.PMID11907122.S2CID45171728.
• Henriksen RA, Hanks VK (2002)."PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets".Arterioscler. Thromb. Vasc. Biol.22(5): 861–6.doi:10.1161/01.ATV.0000014742.56572.25.PMID12006403.S2CID24246544.
• Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome".Thromb. Haemost.87(4): 722–7.doi:10.1055/s-0037-1613071.PMID12008957.S2CID32831294.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin".Biochem. Biophys. Res. Commun.305(1): 166–8.doi:10.1016/S0006-291X(03)00732-0.PMID12732212.
• Adam F, Verbeuren TJ, Fauchère JL, et al. (2003)."Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP".J. Thromb. Haemost.1(4): 798–804.doi:10.1046/j.1538-7836.2003.00138.x.PMID12871418.S2CID12762388.
• Wu CC, Hwang TL, Liao CH, et al. (2004). "The role of PAR4 in thrombin-induced thromboxane production in human platelets".Thromb. Haemost.90(2): 299–308.doi:10.1160/TH03-02-0103.PMID12888878.S2CID4983617.
• Kawai T, Akira S, Reed JC (2003)."ZIP kinase triggers apoptosis from nuclear PML oncogenic domains".Mol. Cell. Biol.23(17): 6174–86.doi:10.1128/MCB.23.17.6174-6186.2003.PMC180930.PMID12917339.
• Jacques SL, Kuliopulos A (2004)."Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage".Biochem. J.376(Pt 3): 733–40.doi:10.1042/BJ20030954.PMC1223816.PMID13678420.
• Han Y, Nurden A, Combrié R, Pasquet JM (2004)."Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium".J. Thromb. Haemost.1(10): 2206–15.doi:10.1046/j.1538-7836.2003.00436.x.PMID14521606.S2CID24420859.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.