FBLN1
FBLN1is the gene encodingfibulin-1,an extracellular matrix and plasma protein.[5][6][7]
Function
[edit]Fibulin-1 is a secretedglycoproteinthat is found in association withextracellular matrixstructures includingfibronectin-containing fibers,elastin-containing fibers andbasement membranes.Fibulin-1 binds to a number of extracellular matrix constituents includingfibronectin,[7]nidogen-1,and theproteoglycan,versican.[7][8]Fibulin-1 is also a blood protein capable of binding tofibrinogen.[9]
Structure
[edit]Fibulin-1 has modular domain structure and includes a series of nineepidermal growth factor-like modules followed by afibulin-type module, a module found in all members of the fibulin gene family.[6]
The human fibulin-1 gene, FBLN1, encodes foursplice variantsdesignated fibulin-1A, B, C and D, which differ in theircarboxy terminalregions. In mouse, chicken and the nematode,C. elegans,only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.[5]
Interactions
[edit]FBLN1 has been shown tointeractwith:
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000077942–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000006369–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: FBLN1 fibulin 1".
- ^abArgraves WS, Tran H, Burgess WH, Dickerson K (Dec 1990)."Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure".The Journal of Cell Biology.111(6 Pt 2): 3155–64.doi:10.1083/jcb.111.6.3155.PMC2116371.PMID2269669.
- ^abcBalbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS (Oct 1992)."Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin".The Journal of Biological Chemistry.267(28): 20120–5.doi:10.1016/S0021-9258(19)88674-X.PMID1400330.
- ^Timpl R, Sasaki T, Kostka G, Chu ML (Jun 2003). "Fibulins: a versatile family of extracellular matrix proteins".Nature Reviews Molecular Cell Biology.4(6): 479–89.doi:10.1038/nrm1130.PMID12778127.S2CID8442153.
- ^abArgraves WS, Tanaka A, Smith EP, Twal WO, Argraves KM, Fan D, Haudenschild CC (Nov 2009). "Fibulin-1 and fibrinogen in human atherosclerotic lesions".Histochemistry and Cell Biology.132(5): 559–65.doi:10.1007/s00418-009-0628-7.PMID19693531.S2CID13501440.
- ^Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999)."The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling".Proceedings of the National Academy of Sciences of the United States of America.96(3): 869–74.Bibcode:1999PNAS...96..869P.doi:10.1073/pnas.96.3.869.PMC15317.PMID9927660.
- ^Ohsawa I, Takamura C, Kohsaka S (Mar 2001). "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and modulates its physiological function".Journal of Neurochemistry.76(5): 1411–20.doi:10.1046/j.1471-4159.2001.00144.x.PMID11238726.S2CID83321033.
- ^Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (Sep 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules".Journal of Molecular Biology.272(2): 226–36.doi:10.1006/jmbi.1997.1244.PMID9299350.
- ^Tran H, VanDusen WJ, Argraves WS (Sep 1997)."The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains".The Journal of Biological Chemistry.272(36): 22600–6.doi:10.1074/jbc.272.36.22600.PMID9278415.
- ^Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML (Aug 1993)."Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands".European Journal of Biochemistry.215(3): 733–40.doi:10.1111/j.1432-1033.1993.tb18086.x.PMID8354280.
- ^Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE (Oct 1992)."Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells".The Journal of Biological Chemistry.267(28): 19840–5.doi:10.1016/S0021-9258(19)88631-3.PMID1400300.
Further reading
[edit]- Balbona K, Tran H, Godyna S, Ingham KC, Strickland DK, Argraves WS (Oct 1992)."Fibulin binds to itself and to the carboxyl-terminal heparin-binding region of fibronectin".The Journal of Biological Chemistry.267(28): 20120–5.doi:10.1016/S0021-9258(19)88674-X.PMID1400330.
- Argraves WS, Tran H, Burgess WH, Dickerson K (Dec 1990)."Fibulin is an extracellular matrix and plasma glycoprotein with repeated domain structure".The Journal of Cell Biology.111(6 Pt 2): 3155–64.doi:10.1083/jcb.111.6.3155.PMC2116371.PMID2269669.
- Argraves WS, Dickerson K, Burgess WH, Ruoslahti E (Aug 1989). "Fibulin, a novel protein that interacts with the fibronectin receptor beta subunit cytoplasmic domain".Cell.58(4): 623–9.doi:10.1016/0092-8674(89)90097-4.PMID2527614.S2CID24834825.
- Sasaki T, Göhring W, Pan TC, Chu ML, Timpl R (Dec 1995). "Binding of mouse and human fibulin-2 to extracellular matrix ligands".Journal of Molecular Biology.254(5): 892–9.doi:10.1006/jmbi.1995.0664.PMID7500359.
- Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD, Argraves WS (Apr 1995)."The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study".The Journal of Histochemistry and Cytochemistry.43(4): 401–11.doi:10.1177/43.4.7534784.PMID7534784.
- Tran H, Tanaka A, Litvinovich SV, Medved LV, Haudenschild CC, Argraves WS (Aug 1995)."The interaction of fibulin-1 with fibrinogen. A potential role in hemostasis and thrombosis".The Journal of Biological Chemistry.270(33): 19458–64.doi:10.1074/jbc.270.33.19458.PMID7642629.
- Mattei MG, Pan TC, Zhang RZ, Timpl R, Chu ML (Jul 1994). "The fibulin-1 gene (FBLN1) is located on human chromosome 22 and on mouse chromosome 15".Genomics.22(2): 437–8.doi:10.1006/geno.1994.1406.PMID7806231.
- Korenberg JR, Chen XN, Tran H, Argraves WS (1995). "Localization of the human gene for fibulin-1 (FBLN1) to chromosome band 22q13.3".Cytogenetics and Cell Genetics.68(3–4): 192–3.doi:10.1159/000133911.PMID7842734.
- Brown JC, Wiedemann H, Timpl R (Jan 1994). "Protein binding and cell adhesion properties of two laminin isoforms (AmB1eB2e, AmB1sB2e) from human placenta".Journal of Cell Science.107(1): 329–38.doi:10.1242/jcs.107.1.329.PMID8175920.
- Pan TC, Kluge M, Zhang RZ, Mayer U, Timpl R, Chu ML (Aug 1993)."Sequence of extracellular mouse protein BM-90/fibulin and its calcium-dependent binding to other basement-membrane ligands".European Journal of Biochemistry.215(3): 733–40.doi:10.1111/j.1432-1033.1993.tb18086.x.PMID8354280.
- Clinton GM, Rougeot C, Derancourt J, Roger P, Defrenne A, Godyna S, Argraves WS, Rochefort H (Jan 1996)."Estrogens increase the expression of fibulin-1, an extracellular matrix protein secreted by human ovarian cancer cells".Proceedings of the National Academy of Sciences of the United States of America.93(1): 316–20.Bibcode:1996PNAS...93..316C.doi:10.1073/pnas.93.1.316.PMC40229.PMID8552629.
- Miosge N, Götz W, Sasaki T, Chu ML, Timpl R, Herken R (Feb 1996). "The extracellular matrix proteins fibulin-1 and fibulin-2 in the early human embryo".The Histochemical Journal.28(2): 109–16.doi:10.1007/BF02331415.PMID8737292.S2CID25996538.
- Godyna S, Diaz-Ricart M, Argraves WS (Oct 1996)."Fibulin-1 mediates platelet adhesion via a bridge of fibrinogen".Blood.88(7): 2569–77.doi:10.1182/blood.V88.7.2569.bloodjournal8872569.PMID8839849.
- Tran H, Mattei M, Godyna S, Argraves WS (Mar 1997). "Human fibulin-1D: molecular cloning, expression and similarity with S1-5 protein, a new member of the fibulin gene family".Matrix Biology.15(7): 479–93.doi:10.1016/S0945-053X(97)90021-4.PMID9106159.
- Tran H, VanDusen WJ, Argraves WS (Sep 1997)."The self-association and fibronectin-binding sites of fibulin-1 map to calcium-binding epidermal growth factor-like domains".The Journal of Biological Chemistry.272(36): 22600–6.doi:10.1074/jbc.272.36.22600.PMID9278415.
- Adam S, Göhring W, Wiedemann H, Chu ML, Timpl R, Kostka G (Sep 1997). "Binding of fibulin-1 to nidogen depends on its C-terminal globular domain and a specific array of calcium-binding epidermal growth factor-like (EG) modules".Journal of Molecular Biology.272(2): 226–36.doi:10.1006/jmbi.1997.1244.PMID9299350.
- Qing J, Maher VM, Tran H, Argraves WS, Dunstan RW, McCormick JJ (Oct 1997)."Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines".Oncogene.15(18): 2159–68.doi:10.1038/sj.onc.1201385.PMID9393974.
- Hayashido Y, Lucas A, Rougeot C, Godyna S, Argraves WS, Rochefort H (Feb 1998)."Estradiol and fibulin-1 inhibit motility of human ovarian- and breast-cancer cells induced by fibronectin".International Journal of Cancer.75(4): 654–8.doi:10.1002/(SICI)1097-0215(19980209)75:4<654::AID-IJC26>3.0.CO;2-7.PMID9466671.
- Roger P, Pujol P, Lucas A, Baldet P, Rochefort H (Nov 1998)."Increased immunostaining of fibulin-1, an estrogen-regulated protein in the stroma of human ovarian epithelial tumors".The American Journal of Pathology.153(5): 1579–88.doi:10.1016/S0002-9440(10)65746-X.PMC1853396.PMID9811350.
- Perbal B, Martinerie C, Sainson R, Werner M, He B, Roizman B (Feb 1999)."The C-terminal domain of the regulatory protein NOVH is sufficient to promote interaction with fibulin 1C: a clue for a role of NOVH in cell-adhesion signaling".Proceedings of the National Academy of Sciences of the United States of America.96(3): 869–74.Bibcode:1999PNAS...96..869P.doi:10.1073/pnas.96.3.869.PMC15317.PMID9927660.