Sex hormone
Sex hormone | |
---|---|
Drug class | |
Class identifiers | |
Synonyms | Sex steroid; Gonadal steroid |
Use | Various |
Biological target | Sex hormone receptors |
Chemical class | Steroidal;Nonsteroidal |
Legal status | |
In Wikidata |
Sex hormones,also known assex steroids,gonadocorticoidsandgonadal steroids,aresteroid hormonesthat interact withvertebratesteroid hormone receptors.[1]The sex hormones include theandrogens,estrogens,andprogestogens.Their effects are mediated by slow genomic mechanisms throughnuclear receptorsas well as by fast nongenomic mechanisms through membrane-associated receptors andsignaling cascades.[2]Thepolypeptidehormonesluteinizing hormone,follicle-stimulating hormoneandgonadotropin-releasing hormone– each associated with thegonadotropinaxis – are usually not regarded as sex hormones, although they play major sex-related roles.
Production
[edit]Natural sex hormones are made by thegonads(ovariesortesticles),[3]byadrenal glands,or by conversion from other sex steroids in other tissue such as liver or fat.[4]
Sex | Sex hormone | Reproductive phase |
Blood production rate |
Gonadal secretion rate |
Metabolic clearance rate |
Reference range (serum levels) | |
---|---|---|---|---|---|---|---|
SIunits | Non-SIunits | ||||||
Men | Androstenedione | –
|
2.8 mg/day | 1.6 mg/day | 2200 L/day | 2.8–7.3 nmol/L | 80–210 ng/dL |
Testosterone | –
|
6.5 mg/day | 6.2 mg/day | 950 L/day | 6.9–34.7 nmol/L | 200–1000 ng/dL | |
Estrone | –
|
150 μg/day | 110 μg/day | 2050 L/day | 37–250 pmol/L | 10–70 pg/mL | |
Estradiol | –
|
60 μg/day | 50 μg/day | 1600 L/day | <37–210 pmol/L | 10–57 pg/mL | |
Estrone sulfate | –
|
80 μg/day | Insignificant | 167 L/day | 600–2500 pmol/L | 200–900 pg/mL | |
Women | Androstenedione | –
|
3.2 mg/day | 2.8 mg/day | 2000 L/day | 3.1–12.2 nmol/L | 89–350 ng/dL |
Testosterone | –
|
190 μg/day | 60 μg/day | 500 L/day | 0.7–2.8 nmol/L | 20–81 ng/dL | |
Estrone | Follicular phase | 110 μg/day | 80 μg/day | 2200 L/day | 110–400 pmol/L | 30–110 pg/mL | |
Luteal phase | 260 μg/day | 150 μg/day | 2200 L/day | 310–660 pmol/L | 80–180 pg/mL | ||
Postmenopause | 40 μg/day | Insignificant | 1610 L/day | 22–230 pmol/L | 6–60 pg/mL | ||
Estradiol | Follicular phase | 90 μg/day | 80 μg/day | 1200 L/day | <37–360 pmol/L | 10–98 pg/mL | |
Luteal phase | 250 μg/day | 240 μg/day | 1200 L/day | 699–1250 pmol/L | 190–341 pg/mL | ||
Postmenopause | 6 μg/day | Insignificant | 910 L/day | <37–140 pmol/L | 10–38 pg/mL | ||
Estrone sulfate | Follicular phase | 100 μg/day | Insignificant | 146 L/day | 700–3600 pmol/L | 250–1300 pg/mL | |
Luteal phase | 180 μg/day | Insignificant | 146 L/day | 1100–7300 pmol/L | 400–2600 pg/mL | ||
Progesterone | Follicular phase | 2 mg/day | 1.7 mg/day | 2100 L/day | 0.3–3 nmol/L | 0.1–0.9 ng/mL | |
Luteal phase | 25 mg/day | 24 mg/day | 2100 L/day | 19–45 nmol/L | 6–14 ng/mL | ||
Notes and sources
Notes:"Theconcentrationof a steroid in the circulation is determined by the rate at which it is secreted from glands, the rate of metabolism of precursor or prehormones into the steroid, and the rate at which it is extracted by tissues and metabolized. Thesecretion rateof a steroid refers to the total secretion of the compound from a gland per unit time. Secretion rates have been assessed by sampling the venous effluent from a gland over time and subtracting out the arterial and peripheral venous hormone concentration. Themetabolic clearance rateof a steroid is defined as the volume of blood that has been completely cleared of the hormone per unit time. Theproduction rateof a steroid hormone refers to entry into the blood of the compound from all possible sources, including secretion from glands and conversion of prohormones into the steroid of interest. At steady state, the amount of hormone entering the blood from all sources will be equal to the rate at which it is being cleared (metabolic clearance rate) multiplied by blood concentration (production rate = metabolic clearance rate × concentration). If there is little contribution of prohormone metabolism to the circulating pool of steroid, then the production rate will approximate the secretion rate. "Sources:See template. |
Types
[edit]In many contexts, the two main classes of sex hormones are androgens and estrogens, of which the most important human derivatives aretestosteroneandestradiol,respectively. Other contexts will includeprogestogensas a third class of sex steroids, distinct from androgens and estrogens.[5]Progesteroneis the most important and only naturally occurring human progestogen. In general, androgens are considered "male sex hormones", since they have masculinizing effects, while estrogens and progestogens are considered "female sex hormones"[6]although all types are present in each sex at different levels.
Sex hormones include:
Synthetic sex steroids
[edit]There are also many synthetic sex steroids.[7]Synthetic androgens are often referred to asanabolic steroids.Synthetic estrogens and progestins are used in methods ofhormonal contraception.Ethinylestradiolis a semi-synthetic estrogen. Specific compounds that have partial agonist activity forsteroid receptors,and therefore act in part like natural steroid hormones, are in use in medical conditions that require treatment with steroid in one cell type, but where systemic effects of the particular steroid in the entire organism are only desirable within certain limits.[8]
See also
[edit]- List of investigational sex-hormonal agents
- Effects of hormones on sexual motivation
- Sex hormone therapy
References
[edit]- ^Guerriero, G (April 2009). "Vertebrate sex steroid receptors: evolution, ligands, and neurodistribution".Annals of the New York Academy of Sciences.1163(1): 154–68.Bibcode:2009NYASA1163..154G.doi:10.1111/j.1749-6632.2009.04460.x.PMID19456336.S2CID5790990.
- ^Thakur, MK; Paramanik, V (2009)."Role of steroid hormone coregulators in health and disease".Hormone Research.71(4): 194–200.doi:10.1159/000201107(inactive 2024-06-11).PMID19258710.
{{cite journal}}
:CS1 maint: DOI inactive as of June 2024 (link) - ^Brook, CG (1999). "Mechanism of puberty".Hormone Research.51 Suppl 3 (3): 52–4.doi:10.1159/000053162(inactive 2024-06-11).PMID10592444.S2CID33671883.
{{cite journal}}
:CS1 maint: DOI inactive as of June 2024 (link) - ^Catherine Panter-Brick; Agustín Fuentes. "Glossary".Health, Risk, and Adversity - Volume 2 of Studies of the Biosocial Society.Berghahn Books, 2011. p. 280.
- ^"An Overview Of Sex Hormones".News-Medical.net.2022-06-24.Retrieved2023-05-22.
- ^ElAttar, TM; Hugoson, A (1974). "Comparative metabolism of female sex steroids in normal and chronically inflamed gingiva of the dog".Journal of Periodontal Research.9(5): 284–9.doi:10.1111/j.1600-0765.1974.tb00683.x.PMID4281823.
- ^"Effect of endogenous and synthetic sex steroids on the clearance of antibody-coated cells".journals.aai.org.Retrieved2023-05-22.
- ^Copland, JA; Sheffield-Moore, M; Koldzic-Zivanovic, N; Gentry, S; Lamprou, G; Tzortzatou-Stathopoulou, F; Zoumpourlis, V; Urban, RJ; Vlahopoulos, SA (June 2009). "Sex steroid receptors in skeletal differentiation and epithelial neoplasia: is tissue-specific intervention possible?".BioEssays.31(6): 629–41.doi:10.1002/bies.200800138.PMID19382224.S2CID205469320.
External links
[edit]- Sex+Steroid+Hormonesat the U.S. National Library of MedicineMedical Subject Headings(MeSH)