Formamidase
| formamidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Formamidase hexamer, Helicobacter pylori | |||||||||
| Identifiers | |||||||||
| EC no. | 3.5.1.49 | ||||||||
| CAS no. | 9013-59-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDBstructures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO/QuickGO | ||||||||
| |||||||||
Inenzymology,aformamidase(EC3.5.1.49) is anenzymethatcatalyzesthechemical reaction
- formamide + H2Oformate + NH3
Thus, the twosubstratesof this enzyme areformamideandH2O,whereas its twoproductsareformateandNH3.
This enzyme belongs to the family ofhydrolases,those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. Thesystematic nameof this enzyme class isformamide amidohydrolase.This enzyme participates inglyoxylate and dicarboxylate metabolismandnitrogen metabolism.
Structural studies
[edit]As of late 2007, fourstructureshave been solved for this class of enzymes, withPDBaccession codes2DYU,2DYV,2E2K,and2E2L.
References
[edit]- Clarke PH (1970). "The aliphatic amidases of Pseudomonas aeruginosa".Adv. Microb. Physiol.Advances in Microbial Physiology.4:179–222.doi:10.1016/S0065-2911(08)60442-7.ISBN978-0-12-027704-9.
- Friedrich CG, Mitrenga G (1981)."Utilization of aliphatic amides and formation of two different amidases by Alcaligenes eutrophus".J. Gen. Microbiol.125(2): 367–374.doi:10.1099/00221287-125-2-367.
