Fyn-related kinase

FRK
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 2D8J,2DLY
Identifiers
Aliases	FRK,GTK, PTK5, RAK, Fyn-related kinase, fyn related Src family tyrosine kinase
External IDs	OMIM:606573;MGI:103265;HomoloGene:48065;GeneCards:FRK;OMA:FRK - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q22.1 Start 115,931,149bp End 116,060,891bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B1 Start 34,359,395bp End 34,487,274bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon epithelium of nasopharynx mucosa of paranasal sinus bronchial epithelial cell buccal mucosa cell palpebral conjunctiva parotid gland sperm corpus epididymis Top expressed in seminal vesicula jejunum duodenum renal pelvis conjunctival fornix large intestine colon inner renal medulla left colon Paneth cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding signaling receptor binding ATP binding non-membrane spanning protein tyrosine kinase activity protein tyrosine kinase activity Cellular component extrinsic component of cytoplasmic side of plasma membrane plasma membrane intracellular anatomical structure extracellular exosome extracellular region nucleus nucleoplasm cytoplasm azurophil granule lumen specific granule lumen cytosol Biological process cell differentiation phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of transcription by RNA polymerase II protein phosphorylation peptidyl-tyrosine autophosphorylation innate immune response negative regulation of cell population proliferation neutrophil degranulation cell migration Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2444 14302 Ensembl ENSG00000111816 ENSMUSG00000019779 UniProt P42685 Q922K9 RefSeq (mRNA) NM_002031 NM_001159544 NM_010237 NM_001358769 RefSeq (protein) NP_002022 NP_001153016 NP_034367 NP_001345698 Location (UCSC) Chr 6: 115.93 – 116.06 Mb Chr 10: 34.36 – 34.49 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Fyn-related kinase(FRK,formerlytyrosine protein kinase 5) is anenzymethat in humans is encoded by theFRKgene.

The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth.

Interactions

FRK has been shown tointeractwithretinoblastoma protein.

Further reading

• Serfas MS, Tyner AL (2003). "Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases".Oncol. Res.13(6–10): 409–19.doi:10.3727/096504003108748438.PMID12725532.
• Craven RJ, Cance WG, Liu ET (1995). "The nuclear tyrosine kinase Rak associates with the retinoblastoma protein pRb".Cancer Res.55(18): 3969–72.PMID7664264.
• Cance WG, Craven RJ, Bergman M, et al. (1995). "Rak, a novel nuclear tyrosine kinase expressed in epithelial cells".Cell Growth Differ.5(12): 1347–55.PMID7696183.
• Cance WG, Craven RJ, Weiner TM, Liu ET (1993). "Novel protein kinases expressed in human breast cancer".Int. J. Cancer.54(4): 571–7.doi:10.1002/ijc.2910540409.PMID8099900.S2CID23352078.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Meyer T, Xu L, Chang J, et al. (2003). "Breast cancer cell line proliferation blocked by the Src-related Rak tyrosine kinase".Int. J. Cancer.104(2): 139–46.doi:10.1002/ijc.10925.PMID12569567.S2CID24095233.
• Watanabe T, Ohnuma T, Shibata N, et al. (2004). "No genetic association between Fyn kinase gene polymorphisms (-93A/G, IVS10+37T/C and Ex12+894T/G) and Japanese sporadic Alzheimer's disease".Neurosci. Lett.360(1–2): 109–11.doi:10.1016/j.neulet.2004.02.046.PMID15082191.S2CID11972631.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005)."Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules".Mol. Cell. Proteomics.4(9): 1240–50.doi:10.1074/mcp.M500089-MCP200.PMID15951569.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.