GABBR2

GABBR2
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 4F11,4F12,4MQE,4MQF,4MR7,4MR8,4MR9,4MRM,4MS1,4MS3,4MS4,4PAS
Identifiers
Aliases	GABBR2,GABABR2, GPR51, GPRC3B, HG20, HRIHFB2099, gamma-aminobutyric acid type B receptor subunit 2, EIEE59, NDPLHS, DEE59
External IDs	OMIM:607340;MGI:2386030;HomoloGene:55902;GeneCards:GABBR2;OMA:GABBR2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9q22.33 Start 98,288,109bp End 98,708,935bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 46,662,305bp End 46,991,873bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in Brodmann area 23 lateral nuclear group of thalamus middle temporal gyrus endothelial cell superior frontal gyrus Brodmann area 46 Brodmann area 10 orbitofrontal cortex parietal lobe postcentral gyrus Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex cerebellum hippocampus proper superior frontal gyrus cerebellar cortex hypothalamus striatum of neuraxis olfactory bulb neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding G protein-coupled receptor activity G protein-coupled GABA receptor activity signal transducer activity protein heterodimerization activity Cellular component cytoplasm integral component of membrane neuron projection cell junction G protein-coupled receptor heterodimeric complex plasma membrane postsynaptic membrane synapse integral component of plasma membrane membrane GABA receptor complex Biological process gamma-aminobutyric acid signaling pathway G protein-coupled receptor signaling pathway negative regulation of adenylate cyclase activity signal transduction chemical synaptic transmission neuron-glial cell signaling Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 9568 242425 Ensembl ENSG00000136928 ENSMUSG00000039809 UniProt O75899 Q80T41 RefSeq (mRNA) NM_005458 NM_001081141 RefSeq (protein) NP_005449 NP_001074610 Location (UCSC) Chr 9: 98.29 – 98.71 Mb Chr 4: 46.66 – 46.99 Mb PubMedsearch
Wikidata
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Gamma-aminobutyric acid (GABA) B receptor, 2(GABA_B2) is aG-protein coupled receptorsubunit encoded by theGABBR2genein humans.

Function

B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors.[supplied by OMIM]

Interactions

GABBR2 has been shown tointeractwithGABBR1.

See also

• GABAB receptor

Further reading

• White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, Marshall FH (1999). "Heterodimerization is required for the formation of a functional GABA(B) receptor".Nature.396(6712): 679–82.Bibcode:1998Natur.396..679W.doi:10.1038/25354.PMID9872316.S2CID4406311.
• Ng GY, Clark J, Coulombe N, Ethier N, Hebert TE, Sullivan R, Kargman S, Chateauneuf A, Tsukamoto N, McDonald T, Whiting P, Mezey E, Johnson MP, Liu Q, Kolakowski LF, Evans JF, Bonner TI, O'Neill GP (1999)."Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity".J. Biol. Chem.274(12): 7607–10.doi:10.1074/jbc.274.12.7607.PMID10075644.
• Ng GY, McDonald T, Bonnert T, Rigby M, Heavens R, Whiting P, Chateauneuf A, Coulombe N, Kargman S, Caskey T, Evans J, O'neill GP, Liu Q (1999). "Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9".Genomics.56(3): 288–95.doi:10.1006/geno.1998.5706.PMID10087195.
• Martin SC, Russek SJ, Farb DH (1999)."Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1".Mol. Cell. Neurosci.13(3): 180–91.doi:10.1006/mcne.1999.0741.PMID10328880.S2CID41258603.
• Clark JA, Mezey E, Lam AS, Bonner TI (2000)."Distribution of the GABA(B) receptor subunit gb2 in rat CNS".Brain Res.860(1–2): 41–52.doi:10.1016/S0006-8993(00)01958-2.PMID10727622.S2CID19334154.
• Sullivan R, Chateauneuf A, Coulombe N, Kolakowski LF, Johnson MP, Hebert TE, Ethier N, Belley M, Metters K, Abramovitz M, O'Neill GP, Ng GY (2000). "Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor".J. Pharmacol. Exp. Ther.293(2): 460–7.PMID10773016.
• White JH, McIllhinney RA, Wise A, Ciruela F, Chan WY, Emson PC, Billinton A, Marshall FH (2001)."The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx".Proc. Natl. Acad. Sci. U.S.A.97(25): 13967–72.Bibcode:2000PNAS...9713967W.doi:10.1073/pnas.240452197.PMC17684.PMID11087824.
• Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi S (2002)."Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins".J. Neurosci.22(4): 1280–9.doi:10.1523/JNEUROSCI.22-04-01280.2002.PMC6757580.PMID11850456.
• Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, Guest PC (2002)."Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation".J. Biol. Chem.277(18): 15482–5.doi:10.1074/jbc.M201539200.PMID11854302.
• Furtinger S, Pirker S, Czech T, Baumgartner C, Sperk G (2004). "Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy".Neurosci. Lett.352(2): 141–5.doi:10.1016/j.neulet.2003.08.046.PMID14625043.S2CID54327057.
• Waldvogel HJ, Billinton A, White JH, Emson PC, Faull RL (2004). "Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits".J. Comp. Neurol.470(4): 339–56.doi:10.1002/cne.20005.PMID14961561.S2CID23646882.
• Balasubramanian S, Teissére JA, Raju DV, Hall RA (2004)."Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking".J. Biol. Chem.279(18): 18840–50.doi:10.1074/jbc.M313470200.PMID14966130.
• Uezono Y, Kaibara M, Hayashi H, Kawakami S, Enjoji A, Kanematsu T, Taniyama K (2004)."Characterization of GABAB receptor in the human colon".J. Pharmacol. Sci.94(2): 211–3.doi:10.1254/jphs.94.211.PMID14978362.
• Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J (2005)."Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR".EMBO J.24(3): 499–509.doi:10.1038/sj.emboj.7600557.PMC548662.PMID15660124.
• DeGiorgis JA, Jaffe H, Moreira JE, Carlotti CG, Leite JP, Pant HC, Dosemeci A (2005). "Phosphoproteomic analysis of synaptosomes from human cerebral cortex".J. Proteome Res.4(2): 306–15.doi:10.1021/pr0498436.PMID15822905.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J,Zoghbi HY,Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
• Osawa Y, Xu D, Sternberg D, Sonett JR, D'Armiento J, Panettieri RA, Emala CW (2006). "Functional expression of the GABAB receptor in human airway smooth muscle".Am. J. Physiol. Lung Cell Mol. Physiol.291(5): L923–31.doi:10.1152/ajplung.00185.2006.PMID16829628.

External links

• "GABA_BReceptors: GABA_B2".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology.
• Overview of all the structural information available in thePDBforUniProt:O75899(Gamma-aminobutyric acid type B receptor subunit 2) at thePDBe-KB.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.