GABRG1
Gamma-aminobutyric acid receptor subunit gamma-1is aproteinthat in humans is encoded by theGABRG1gene.[5]Theproteinencoded by this gene is a subunit of theGABAA receptor.[6]
Variants of this gene may be associated withalcohol dependence.[7]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000163285–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000001260–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Wilcox AS, Warrington JA, Gardiner K, Berger R, Whiting P, Altherr MR, Wasmuth JJ, Patterson D, Sikela JM (July 1992)."Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome".Proc. Natl. Acad. Sci. U.S.A.89(13): 5857–5861.Bibcode:1992PNAS...89.5857W.doi:10.1073/pnas.89.13.5857.PMC49396.PMID1321425.
- ^Hevers W, Lüddens H (August 1998). "The diversity of GABAA receptors. Pharmacological and electrophysiological properties of GABAA channel subtypes".Mol. Neurobiol.18(1): 35–86.doi:10.1007/BF02741459.PMID9824848.S2CID32359279.
- ^Ittiwut C, Listman J, Mutirangura A, Malison R, Covault J, Kranzler HR, Sughondhabirom A, Thavichachart N, Gelernter J (January 2008)."Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4".Genomics.91(1): 61–69.doi:10.1016/j.ygeno.2007.08.007.PMC2709929.PMID17976953.
Further reading
[edit]- Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors".J. Neurochem.80(5): 815–823.doi:10.1046/j.0022-3042.2002.00762.x.PMID11948245.S2CID38049055.
- Iwakiri M, Mizukami K, Ikonomovic MD, et al. (2009)."An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression".Neuropathology.29(3): 263–269.doi:10.1111/j.1440-1789.2008.00978.x.PMC3078755.PMID19019179.
- Craddock N, Jones L, Jones IR, et al. (2010)."Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype".Mol. Psychiatry.15(2): 146–153.doi:10.1038/mp.2008.66.PMC3967096.PMID19078961.
- Ray LA, Hutchison KE (2009)."Associations among GABRG1, level of response to alcohol, and drinking behaviors".Alcohol. Clin. Exp. Res.33(8): 1382–1390.doi:10.1111/j.1530-0277.2009.00968.x.PMC2965732.PMID19426171.
- Ittiwut C, Listman J, Mutirangura A, et al. (2008)."Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4".Genomics.91(1): 61–69.doi:10.1016/j.ygeno.2007.08.007.PMC2709929.PMID17976953.
- Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment".Am. J. Med. Genet. B Neuropsychiatr. Genet.150B(6): 808–816.doi:10.1002/ajmg.b.30902.PMID19086053.S2CID44524739.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–45.doi:10.1038/ng1285.PMID14702039.
- Bonnert TP, McKernan RM, Farrar S, et al. (1999)."theta, a novel gamma-aminobutyric acid type A receptor subunit".Proc. Natl. Acad. Sci. U.S.A.96(17): 9891–9896.Bibcode:1999PNAS...96.9891B.doi:10.1073/pnas.96.17.9891.PMC22306.PMID10449790.
- Guilmatre A, Dubourg C, Mosca AL, et al. (2009)."Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation".Arch. Gen. Psychiatry.66(9): 947–956.doi:10.1001/archgenpsychiatry.2009.80.PMC2958844.PMID19736351.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–16903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
- Ma DQ, Whitehead PL, Menold MM, et al. (2005)."Identification of significant association and gene-gene interaction of GABA receptor subunit genes in autism".Am. J. Hum. Genet.77(3): 377–388.doi:10.1086/433195.PMC1226204.PMID16080114.
- Covault J, Gelernter J, Jensen K, et al. (2008)."Markers in the 5'-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene".Neuropsychopharmacology.33(4): 837–848.doi:10.1038/sj.npp.1301456.PMC2743531.PMID17507911.
- Enoch MA, Hodgkinson CA, Yuan Q, et al. (2009)."GABRG1 and GABRA2 as independent predictors for alcoholism in two populations".Neuropsychopharmacology.34(5): 1245–1254.doi:10.1038/npp.2008.171.PMC2656604.PMID18818659.
- Wilcox AS, Warrington JA, Gardiner K, et al. (1992)."Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genome".Proc. Natl. Acad. Sci. U.S.A.89(13): 5857–5861.Bibcode:1992PNAS...89.5857W.doi:10.1073/pnas.89.13.5857.PMC49396.PMID1321425.
External links
[edit]- GABRG1+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
 | Thismembrane protein–related article is astub.You can help Wikipedia byexpanding it. |