GABRG3

GABRG3
Identifiers
Aliases	GABRG3,gamma-aminobutyric acid type A receptor gamma3 subunit, gamma-aminobutyric acid type A receptor subunit gamma3
External IDs	OMIM:600233;MGI:95624;HomoloGene:22444;GeneCards:GABRG3;OMA:GABRG3 - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q12 Start 26,971,181bp End 27,541,984bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B5|7 33.48 cM Start 56,366,213bp End 57,036,936bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in testicle right testis left testis prefrontal cortex gonad anterior pituitary sperm Brodmann area 9 hypothalamus cingulate gyrus Top expressed in epithelium of lens lumbar subsegment of spinal cord nucleus accumbens superior frontal gyrus lateral septal nucleus dorsal striatum prefrontal cortex dentate gyrus of hippocampal formation granule cell lumbar spinal ganglion primary visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chloride channel activity extracellular ligand-gated ion channel activity GABA-A receptor activity ion channel activity transmembrane signaling receptor activity inhibitory extracellular ligand-gated ion channel activity benzodiazepine receptor activity GABA-gated chloride ion channel activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential Cellular component integral component of membrane cell junction plasma membrane postsynaptic membrane synapse membrane chloride channel complex GABA-ergic synapse integral component of synaptic membrane integral component of plasma membrane dendrite membrane neuron projection postsynapse GABA-A receptor complex Biological process gamma-aminobutyric acid signaling pathway chloride transport chloride transmembrane transport ion transport ion transmembrane transport signal transduction chemical synaptic transmission regulation of membrane potential nervous system process synaptic transmission, GABAergic regulation of postsynaptic membrane potential Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2567 14407 Ensembl ENSG00000182256 ENSMUSG00000055026 UniProt Q99928 P27681 RefSeq (mRNA) NM_001270873 NM_033223 NM_008074 NM_177273 RefSeq (protein) NP_001257802 NP_150092 NP_032100 Location (UCSC) Chr 15: 26.97 – 27.54 Mb Chr 7: 56.37 – 57.04 Mb PubMedsearch
Wikidata
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GABA_Areceptor-γ3,also known asGABRG3,is aproteinwhich in humans is encoded by theGABRG3gene.

Function

GABRG3 is a subunit of theGABA_Areceptorfor the neurotransmitter gamma-Aminobutyric acid (GABA).

Association with alcoholism

Genetic markers near theGABRG3gene are statistically linked toalcoholism.

See also

• GABAA receptor

Further reading

• Greger V, Knoll JH, Woolf E, et al. (1995). "The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation".Genomics.26(2): 258–264.doi:10.1016/0888-7543(95)80209-5.PMID7601451.
• Tögel M, Mossier B, Fuchs K, Sieghart W (1994)."gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties".J. Biol. Chem.269(17): 12993–12998.doi:10.1016/S0021-9258(18)99974-6.PMID8175718.
• Hadingham KL, Wafford KA, Thompson SA, et al. (1996). "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits".Eur. J. Pharmacol.291(3): 301–309.doi:10.1016/0922-4106(95)90070-5.PMID8719414.
• Poulsen CF, Christjansen KN, Hastrup S, Hartvig L (2000). "Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor".Brain Res. Mol. Brain Res.78(1–2): 201–203.doi:10.1016/S0169-328X(00)00085-1.PMID10891602.
• Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression".Nat. Biotechnol.19(5): 440–445.doi:10.1038/88107.PMID11329013.S2CID25064683.
• Nymann-Andersen J, Wang H, Chen L, et al. (2002). "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors".J. Neurochem.80(5): 815–823.doi:10.1046/j.0022-3042.2002.00762.x.PMID11948245.S2CID38049055.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–16903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Dick DM, Edenberg HJ, Xuei X, et al. (2004). "Association of GABRG3 with alcohol dependence".Alcohol. Clin. Exp. Res.28(1): 4–9.CiteSeerX10.1.1.418.2528.doi:10.1097/01.ALC.0000108645.54345.98.PMID14745296.
• Gole L, Crolla JA, Thomas SN, et al. (2004). "Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12)".Am. J. Med. Genet. A.125(2): 177–180.doi:10.1002/ajmg.a.20482.PMID14981720.S2CID44727697.

External links

• GABRG3+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.