GNA12
Guanine nucleotide-binding protein subunit alpha-12is aproteinthat in humans is encoded by theGNA12gene.[5][6][7]
Interactions and functions
[edit]The GNA12 gene encodes the G12G protein alpha subunit.Together withGNA13,these two proteins comprise one of the four classes ofheterotrimeric G proteinalpha subunits.[8]Heterotrimeric G proteins function in transducinghormoneandneurotransmittersignals detected by cell surfaceG protein-coupled receptorstointracellular signaling pathwaysto modulate cell functions. G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound toGTPbut inactive and associated with theG beta-gamma complexwhen bound toGDP.[9][10]
Active GTP-bound G12alpha subunitinteractswith and activatesARHGEF1,[11]ARHGEF11,[12][13]andARHGEF12.[14][15]These ARHGEF proteins function asguanine nucleotide exchange factorsfor theRhosmall GTPasesto regulate theactincytoskeleton.[16]
GNA12 also interacts withPPP5C,[17]HSP90,[18]Resistance to inhibitors of cholinesterase-8A (Ric-8A)[19]andTEC.[15]
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000146535–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000000149–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993)."Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product".Molecular and Cellular Biology.13(2): 762–8.doi:10.1128/mcb.13.2.762.PMC358958.PMID8423800.
- ^Kumar RN, Shore SK, Dhanasekaran N (February 2006)."Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3".Oncogene.25(6): 899–906.doi:10.1038/sj.onc.1209132.PMID16247467.
- ^"Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
- ^Strathmann MP, Simon MI (1991)."G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits".Proc. Natl. Acad. Sci. U.S.A.88(13): 5582–6.Bibcode:1991PNAS...88.5582S.doi:10.1073/pnas.88.13.5582.PMC51921.PMID1905812.
- ^Gilman, AG (1987). "G proteins: transducers of receptor-generated signals".Annual Review of Biochemistry.56:615–649.doi:10.1146/annurev.bi.56.070187.003151.PMID3113327.
- ^Rodbell, M (1995)."Nobel Lecture: Signal transduction: Evolution of an idea".Bioscience Reports.15(3): 117–133.doi:10.1007/bf01207453.PMC1519115.PMID7579038.S2CID11025853.
- ^Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003)."RGS16 inhibits signalling through the G alpha 13-Rho axis".Nature Cell Biology.5(12): 1095–103.doi:10.1038/ncb1065.PMID14634662.S2CID6798899.
- ^Fukuhara, S; Murga, C; Zohar, M; Igishi, T; Gutkind, JS (1999-02-26)."A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho".Journal of Biological Chemistry.274(9): 5868–5879.doi:10.1074/jbc.274.9.5868.PMID10026210.
- ^Rümenapp, U; Blomquist, A; Schwörer, G; Schablowski, H; Psoma, A; Jakobs, KH (1999-10-15). "Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member".FEBS Letters.459(3): 313–318.doi:10.1016/s0014-5793(99)01270-3.PMID10526156.S2CID8529412.
- ^Fukuhara S, Chikumi H, Gutkind JS (November 2000)."Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho".FEBS Letters.485(2–3): 183–8.doi:10.1016/S0014-5793(00)02224-9.PMID11094164.S2CID7300556.
- ^abSuzuki N, Nakamura S, Mano H, Kozasa T (January 2003)."Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF".Proceedings of the National Academy of Sciences of the United States of America.100(2): 733–8.Bibcode:2003PNAS..100..733S.doi:10.1073/pnas.0234057100.PMC141065.PMID12515866.
- ^Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins".Cell. Signal.8(4): 235–45.doi:10.1016/0898-6568(96)00048-4.PMID8842523.
- ^Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002)."Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity".Current Biology.12(15): 1353–8.doi:10.1016/S0960-9822(02)01034-5.PMID12176367.S2CID11485795.
- ^Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001)."Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling".The Journal of Biological Chemistry.276(49): 46088–93.doi:10.1074/jbc.M108711200.PMID11598136.
- ^Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011)."Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization".The Journal of Biological Chemistry.286(35): 31055–61.doi:10.1074/jbc.M111.253427.PMC3162464.PMID21771786.
External links
[edit]- GNA12+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
- Overview of all the structural information available in thePDBforUniProt:P27600(Mouse Guanine nucleotide-binding protein subunit alpha-12 (GNA12)) at thePDBe-KB.
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