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Receptor for activated C kinase 1

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(Redirected fromGNB2L1)

RACK1
Available structures
PDBOrtholog search:PDBeRCSB
Identifiers
AliasesRACK1,Gnb2-rs1, H12.3, HLC-7, PIG21, GNB2L1, receptor for activated C kinase 1
External IDsOMIM:176981;MGI:101849;HomoloGene:4446;GeneCards:RACK1;OMA:RACK1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

10399

14694

Ensembl

ENSG00000204628

ENSMUSG00000020372

UniProt

P63244

P68040

RefSeq (mRNA)

NM_006098

NM_008143

RefSeq (protein)

NP_006089

NP_032169

Location (UCSC)Chr 5: 181.24 – 181.25 MbChr 11: 48.69 – 48.7 Mb
PubMedsearch[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Receptor for activated C kinase 1(RACK1), also known asguanine nucleotide-binding protein subunit beta-2-like 1(GNB2L1), is a 35kDaproteinthat in humans is encoded by the RACK1gene.[5][6]

Function

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RACK1 was originally isolated and identified as an intracellular protein receptor forprotein kinase C,noting the significant homology to the beta subunit ofheterotrimeric G proteins.[5]Later studies established RACK1, and its yeast homolog Asc1, as a coreribosomal proteinof theeukaryotic small (40S) ribosomal subunit.[7][8][9]Much of the function of Asc1/RACK1 appears to result from its position on the 'head' of the 40S ribosomal subunit.[10]Asc1/RACK1 participates in several aspects ofeukaryotic translationandribosome quality control,includingIRES-mediated translation,[11]non-stop decay,[12]non-functional18S ribosomal RNAdecay,[13]andframeshifting.[14]

Interactions

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RACK1 is positioned at the solvent-exposed surface of the40S ribosomal subunit,where it is held in place through contacts with both the18S rRNAand otherribosomal proteins,includinguS3,uS9,andeS17.Additionally, RACK1 has been shown tointeractwith:

See also

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References

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  1. ^abcGRCh38: Ensembl release 89: ENSG00000204628–Ensembl,May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000020372–Ensembl,May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^abRon D, Chen CH, Caldwell J, Jamieson L, Orr E, Mochly-Rosen D (February 1994)."Cloning of an intracellular receptor for protein kinase C: a homolog of the beta subunit of G proteins".Proceedings of the National Academy of Sciences of the United States of America.91(3): 839–43.Bibcode:1994PNAS...91..839R.doi:10.1073/pnas.91.3.839.PMC521407.PMID8302854.
  6. ^Guillemot F, Billault A, Auffray C (June 1989)."Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex".Proceedings of the National Academy of Sciences of the United States of America.86(12): 4594–8.Bibcode:1989PNAS...86.4594G.doi:10.1073/pnas.86.12.4594.PMC287317.PMID2499885.
  7. ^Sengupta J, Nilsson J, Gursky R, Spahn CM, Nissen P, Frank J (October 2004). "Identification of the versatile scaffold protein RACK1 on the eukaryotic ribosome by cryo-EM".Nature Structural & Molecular Biology.11(10): 957–62.doi:10.1038/nsmb822.PMID15334071.S2CID20751757.
  8. ^Gerbasi VR, Weaver CM, Hill S, Friedman DB, Link AJ (September 2004)."Yeast Asc1p and mammalian RACK1 are functionally orthologous core 40S ribosomal proteins that repress gene expression".Molecular and Cellular Biology.24(18): 8276–87.doi:10.1128/mcb.24.18.8276-8287.2004.PMC515043.PMID15340087.
  9. ^Rabl J, Leibundgut M, Ataide SF, Haag A, Ban N (February 2011). "Crystal structure of the eukaryotic 40S ribosomal subunit in complex with initiation factor 1".Science.331(6018): 730–6.Bibcode:2011Sci...331..730R.doi:10.1126/science.1198308.hdl:20.500.11850/153130.PMID21205638.S2CID24771575.
  10. ^Coyle SM, Gilbert WV, Doudna JA (March 2009)."Direct link between RACK1 function and localization at the ribosome in vivo".Molecular and Cellular Biology.29(6): 1626–34.doi:10.1128/mcb.01718-08.PMC2648249.PMID19114558.
  11. ^Majzoub K, Hafirassou ML, Meignin C, Goto A, Marzi S, Fedorova A, Verdier Y, Vinh J, Hoffmann JA, Martin F, Baumert TF, Schuster C, Imler JL (November 2014)."RACK1 controls IRES-mediated translation of viruses".Cell.159(5): 1086–1095.doi:10.1016/j.cell.2014.10.041.PMC4243054.PMID25416947.
  12. ^Ikeuchi K, Inada T (June 2016)."Ribosome-associated Asc1/RACK1 is required for endonucleolytic cleavage induced by stalled ribosome at the 3' end of nonstop mRNA".Scientific Reports.6(1): 28234.Bibcode:2016NatSR...628234I.doi:10.1038/srep28234.PMC4911565.PMID27312062.
  13. ^Limoncelli KA, Merrikh CN, Moore MJ (December 2017)."ASC1 and RPS3: new actors in 18S nonfunctional rRNA decay".RNA.23(12): 1946–1960.doi:10.1261/rna.061671.117.PMC5689013.PMID28956756.
  14. ^Wolf AS, Grayhack EJ (May 2015)."Asc1, homolog of human RACK1, prevents frameshifting in yeast by ribosomes stalled at CGA codon repeats".RNA.21(5): 935–45.doi:10.1261/rna.049080.114.PMC4408800.PMID25792604.
  15. ^Wang W, Huang Y, Zhou Z, Tang R, Zhao W, Zeng L, Xu M, Cheng C, Gu S, Ying K, Xie Y, Mao Y (January 2002). "Identification and characterization of AGTRAP, a human homolog of murine Angiotensin II Receptor-Associated Protein (Agtrap)".The International Journal of Biochemistry & Cell Biology.34(1): 93–102.doi:10.1016/s1357-2725(01)00094-2.PMID11733189.
  16. ^Rigas AC, Ozanne DM, Neal DE, Robson CN (November 2003)."The scaffolding protein RACK1 interacts with androgen receptor and promotes cross-talk through a protein kinase C signaling pathway".The Journal of Biological Chemistry.278(46): 46087–93.doi:10.1074/jbc.M306219200.PMID12958311.
  17. ^abLiliental J, Chang DD (January 1998)."Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit".The Journal of Biological Chemistry.273(4): 2379–83.doi:10.1074/jbc.273.4.2379.PMID9442085.
  18. ^Lee HS, Millward-Sadler SJ, Wright MO, Nuki G, Al-Jamal R, Salter DM (November 2002)."Activation of Integrin-RACK1/PKCalpha signalling in human articular chondrocyte mechanotransduction".Osteoarthritis and Cartilage.10(11): 890–7.doi:10.1053/joca.2002.0842.PMID12435334.
  19. ^Diederichs S, Bäumer N, Ji P, Metzelder SK, Idos GE, Cauvet T, Wang W, Möller M, Pierschalski S, Gromoll J, Schrader MG, Koeffler HP, Berdel WE, Serve H, Müller-Tidow C (August 2004)."Identification of interaction partners and substrates of the cyclin A1-CDK2 complex".The Journal of Biological Chemistry.279(32): 33727–41.doi:10.1074/jbc.M401708200.PMID15159402.
  20. ^Ceci M, Gaviraghi C, Gorrini C, Sala LA, Offenhäuser N, Marchisio PC, Biffo S (December 2003). "Release of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assembly".Nature.426(6966): 579–84.Bibcode:2003Natur.426..579C.doi:10.1038/nature02160.PMID14654845.S2CID2431706.
  21. ^Yaka R, He DY, Phamluong K, Ron D (March 2003)."Pituitary adenylate cyclase-activating polypeptide (PACAP(1-38)) enhances N-methyl-D-aspartate receptor function and brain-derived neurotrophic factor expression via RACK1".The Journal of Biological Chemistry.278(11): 9630–8.doi:10.1074/jbc.M209141200.PMID12524444.
  22. ^Yaka R, Thornton C, Vagts AJ, Phamluong K, Bonci A, Ron D (April 2002)."NMDA receptor function is regulated by the inhibitory scaffolding protein, RACK1".Proceedings of the National Academy of Sciences of the United States of America.99(8): 5710–5.Bibcode:2002PNAS...99.5710Y.doi:10.1073/pnas.062046299.PMC122836.PMID11943848.
  23. ^abUsacheva A, Smith R, Minshall R, Baida G, Seng S, Croze E, Colamonici O (June 2001)."The WD motif-containing protein receptor for activated protein kinase C (RACK1) is required for recruitment and activation of signal transducer and activator of transcription 1 through the type I interferon receptor".The Journal of Biological Chemistry.276(25): 22948–53.doi:10.1074/jbc.M100087200.PMID11301323.
  24. ^Croze E, Usacheva A, Asarnow D, Minshall RD, Perez HD, Colamonici O (November 2000)."Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor".Journal of Immunology.165(9): 5127–32.doi:10.4049/jimmunol.165.9.5127.PMID11046044.
  25. ^abcUsacheva A, Tian X, Sandoval R, Salvi D, Levy D, Colamonici OR (September 2003)."The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex".Journal of Immunology.171(6): 2989–94.doi:10.4049/jimmunol.171.6.2989.PMID12960323.
  26. ^Edelmann MJ, Iphöfer A, Akutsu M, Altun M, di Gleria K, Kramer HB, Fiebiger E, Dhe-Paganon S, Kessler BM (March 2009)."Structural basis and specificity of human otubain 1-mediated deubiquitination"(PDF).The Biochemical Journal.418(2): 379–90.doi:10.1042/BJ20081318.PMID18954305.
  27. ^Ozaki T, Watanabe K, Nakagawa T, Miyazaki K, Takahashi M, Nakagawara A (May 2003)."Function of p73, not of p53, is inhibited by the physical interaction with RACK1 and its inhibitory effect is counteracted by pRB".Oncogene.22(21): 3231–42.doi:10.1038/sj.onc.1206382.PMID12761493.
  28. ^Yarwood SJ, Steele MR, Scotland G, Houslay MD, Bolger GB (May 1999)."The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform".The Journal of Biological Chemistry.274(21): 14909–17.doi:10.1074/jbc.274.21.14909.PMID10329691.
  29. ^Steele MR, McCahill A, Thompson DS, MacKenzie C, Isaacs NW, Houslay MD, Bolger GB (July 2001). "Identification of a surface on the beta-propeller protein RACK1 that interacts with the cAMP-specific phosphodiesterase PDE4D5".Cellular Signalling.13(7): 507–13.doi:10.1016/s0898-6568(01)00167-x.PMID11516626.
  30. ^Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999)."Coordinated movement of RACK1 with activated betaIIPKC".The Journal of Biological Chemistry.274(38): 27039–46.doi:10.1074/jbc.274.38.27039.PMID10480917.
  31. ^Liedtke CM, Yun CH, Kyle N, Wang D (June 2002)."Protein kinase C epsilon-dependent regulation of cystic fibrosis transmembrane regulator involves binding to a receptor for activated C kinase (RACK1) and RACK1 binding to Na+/H+ exchange regulatory factor".The Journal of Biological Chemistry.277(25): 22925–33.doi:10.1074/jbc.M201917200.PMID11956211.
  32. ^Hellberg CB, Burden-Gulley SM, Pietz GE, Brady-Kalnay SM (March 2002)."Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells".The Journal of Biological Chemistry.277(13): 11165–73.doi:10.1074/jbc.M112157200.PMID11801604.
  33. ^Mourton T, Hellberg CB, Burden-Gulley SM, Hinman J, Rhee A, Brady-Kalnay SM (May 2001)."The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts".The Journal of Biological Chemistry.276(18): 14896–901.doi:10.1074/jbc.M010823200.PMID11278757.
  34. ^Koehler JA, Moran MF (May 2001). "RACK1, a protein kinase C scaffolding protein, interacts with the PH domain of p120GAP".Biochemical and Biophysical Research Communications.283(4): 888–95.doi:10.1006/bbrc.2001.4889.PMID11350068.
  35. ^Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways".Biochemistry.42(24): 7270–82.doi:10.1021/bi034081y.PMID12809483.
  36. ^Chang BY, Conroy KB, Machleder EM, Cartwright CA (June 1998)."RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells".Molecular and Cellular Biology.18(6): 3245–56.doi:10.1128/mcb.18.6.3245.PMC108906.PMID9584165.

Further reading

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