GPR116

ADGRF5
Identifiers
Aliases	ADGRF5,KPG_001, GPR116, adhesion G protein-coupled receptor F5
External IDs	MGI:2182928;HomoloGene:9065;GeneCards:ADGRF5;OMA:ADGRF5 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	46,954,943bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	43,770,448bp
RNA expressionpattern
	Top expressed in
	lower lobe of lung; ; visceral pleura; ; right lung; ; upper lobe of lung; ; upper lobe of left lung; ; renal medulla; ; right ventricle; ; metanephric glomerulus; ; vena cava; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung lobe; ; endothelial cell of lymphatic vessel; ; interventricular septum; ; myocardium of ventricle; ; extraocular muscle; ; digastric muscle; ; soleus muscle; ; brown adipose tissue;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	integral component of membrane; cell surface; plasma membrane; apical part of cell; cytoplasmic vesicle; membrane;
Biological process	surfactant homeostasis; negative regulation of macrophage activation; G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; energy reserve metabolic process; regulation of lipid metabolic process; fat cell differentiation; positive regulation of phospholipid biosynthetic process; glucose homeostasis; signal transduction; glomerular filtration; erythrocyte development; pharyngeal arch artery morphogenesis;
	Sources:Amigo/QuickGO
Orthologs
	221395
	224792
	ENSG00000069122
	ENSMUSG00000056492
	Q8IZF2
	G5E8Q8
	NM_001098518; NM_015234
	NM_001081178; NM_001357332
	NP_001091988; NP_056049
NP_001074647; NP_001344261; NP_001391458; NP_001391459; NP_001391465;
	NP_001391470; NP_001391475; NP_001391477
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 116is aproteinthat in humans is encoded by theGPR116gene.^[5]^[6]^[7]GPR116 has now been shown to play an essential role in the regulation oflung surfactanthomeostasis.^[8]^[9]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000069122–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000056492–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Stacey, edited by S Yona, M Stacey (2010).Adhesion-GPCRs: structure to function.New York: Springer Science+Business Media.ISBN 978-1-4419-7912-4.{{cite book}}:|first=has generic name (help)CS1 maint: multiple names: authors list (link)
^Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002)."Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions".FEBS Letters.531(3): 407–14.doi:10.1016/S0014-5793(02)03574-3.PMID 12435584.S2CID 7449692.
^"Entrez Gene: GPR116 G protein-coupled receptor 116".
^Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013)."Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116".Cell Reports.3(5): 1457–64.doi:10.1016/j.celrep.2013.04.019.PMC3695742.PMID 23684610.
^Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013)."Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D".PLOS ONE.8(7): e69451.Bibcode:2013PLoSO...869451F.doi:10.1371/journal.pone.0069451.PMC3726689.PMID 23922714.

Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (Apr 2003)."The G protein-coupled receptor repertoires of human and mouse".Proceedings of the National Academy of Sciences of the United States of America.100(8): 4903–8.Bibcode:2003PNAS..100.4903V.doi:10.1073/pnas.0230374100.PMC153653.PMID 12679517.
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84(1): 23–33.doi:10.1016/j.ygeno.2003.12.004.PMID 15203201.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004)."From ORFeome to biology: a functional genomics pipeline".Genome Research.14(10B): 2136–44.doi:10.1101/gr.2576704.PMC528930.PMID 15489336.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069122–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056492–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Stacey, edited by S Yona, M Stacey (2010).Adhesion-GPCRs: structure to function.New York: Springer Science+Business Media.ISBN 978-1-4419-7912-4.{{cite book}}:|first=has generic name (help)CS1 maint: multiple names: authors list (link)

[pmid12435584-6] Fredriksson R, Lagerström MC, Höglund PJ, Schiöth HB (Nov 2002)."Novel human G protein-coupled receptors with long N-terminals containing GPS domains and Ser/Thr-rich regions".FEBS Letters.531(3): 407–14.doi:10.1016/S0014-5793(02)03574-3.PMID 12435584.S2CID 7449692.

[entrez-7] "Entrez Gene: GPR116 G protein-coupled receptor 116".

[8] Yang MY, Hilton MB, Seaman S, Haines DC, Nagashima K, Burks CM, Tessarollo L, Ivanova PT, Brown HA, Umstead TM, Floros J, Chroneos ZC, St Croix B (May 2013)."Essential regulation of lung surfactant homeostasis by the orphan G protein-coupled receptor GPR116".Cell Reports.3(5): 1457–64.doi:10.1016/j.celrep.2013.04.019.PMC3695742.PMID 23684610.

[9] Fukuzawa T, Ishida J, Kato A, Ichinose T, Ariestanti DM, Takahashi T, Ito K, Abe J, Suzuki T, Wakana S, Fukamizu A, Nakamura N, Hirose S (2013)."Lung surfactant levels are regulated by Ig-Hepta/GPR116 by monitoring surfactant protein D".PLOS ONE.8(7): e69451.Bibcode:2013PLoSO...869451F.doi:10.1371/journal.pone.0069451.PMC3726689.PMID 23922714.

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References

Further reading