GPR125

For the motorcycle, seeDerbi GPR125.

ADGRA3
Identifiers
Aliases	ADGRA3,PGR21, TEM5L, GPR125, adhesion G protein-coupled receptor A3
External IDs	OMIM:612303;MGI:1917943;HomoloGene:19235;GeneCards:ADGRA3;OMA:ADGRA3 - orthologs
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 B3 Start 50,117,298bp End 50,216,348bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in ganglionic eminence right lobe of liver right uterine tube stromal cell of endometrium synovial joint Achilles tendon rectum transverse colon hair follicle secondary oocyte Top expressed in Gonadal ridge mandibular prominence maxillary prominence hair follicle tail of embryo facial skeleton molar vestibular sensory epithelium Dermatocranium somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity protein binding transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane membrane external side of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 166647 70693 Ensembl n/a ENSMUSG00000029090 UniProt Q8IWK6 Q7TT36 RefSeq (mRNA) NM_145290 NM_133911 RefSeq (protein) NP_660333 NP_598672 Location (UCSC) n/a Chr 5: 50.12 – 50.22 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Adhesion G-protein coupled receptor A3 (ADGRA3),also known as GPR125, is anadhesion GPCRthat in humans is encoded by theAdgra3gene(previouslyGpr125).

Further reading

• Seandel M; et al. (2007)."Generation of functional multipotent adult stem cells from GPR125+ germline progenitors".Nature.449(7160): 346–50.Bibcode:2007Natur.449..346S.doi:10.1038/nature06129.PMC2935199.PMID17882221.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Yamamoto Y, Irie K, Asada M, et al. (2004). "Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein".Oncogene.23(22): 3889–97.doi:10.1038/sj.onc.1207495.PMID15021905.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84(1): 23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID17081983.S2CID7827573.