G protein-coupled receptor 128is aproteinencoded by theADGRG7gene.[5][6][7]GPR128 is a member of theadhesion GPCRfamily.[8][9]
Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing(GAIN)domain.[10]
GPR128 is specifically expressed in human liver as well as in mouse bone marrow and intestinal tissues.[11]
A 111-kb copy number gain with breakpoints within the TRK-fused gene (a target of translocations in lymphoma and thyroid tumors) and GPR128 has been identified in the genome of patients with atypical myeloproliferative neoplasms.[13]Notably, the fused gene was also detected in few healthy individuals.
^Stacey M, Yona S (2011).Adhesion-GPCRs: Structure to Function (Advances in Experimental Medicine and Biology).Berlin: Springer.ISBN978-1-4419-7912-4.
^Langenhan, T; Aust, G; Hamann, J (21 May 2013). "Sticky signaling--adhesion class G protein-coupled receptors take the stage".Science Signaling.6(276): re3.doi:10.1126/scisignal.2003825.PMID23695165.S2CID6958640.