GPR39

GPR39
Identifiers
Aliases	GPR39,G protein-coupled receptor 39
External IDs	OMIM:602886;MGI:1918361;HomoloGene:20380;GeneCards:GPR39;OMA:GPR39 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	132,646,582bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	125,801,599bp
RNA expressionpattern
	Top expressed in
	oocyte; ; secondary oocyte; ; gonad; ; sperm; ; ganglionic eminence; ; ventricular zone; ; right uterine tube; ; mucosa of transverse colon; ; internal globus pallidus; ; nucleus accumbens;
	Top expressed in
	transitional epithelium of urinary bladder; ; yolk sac; ; spermatid; ; duodenum; ; stomach; ; seminal vesicula; ; jejunum; ; embryo; ; esophagus; ; epithelium of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; metal ion binding;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo/QuickGO
Orthologs
	2863
	71111
	ENSG00000183840
	ENSMUSG00000026343
	O43194
	Q5U431
	NM_001508
	NM_027677
	NP_001499
	NP_081953
	Wikidata
View/Edit Human	View/Edit Mouse

G-protein coupled receptor 39is aproteinthat in humans is encoded by theGPR39gene.^[5]^[6]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000183840–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000026343–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors".Genomics.46(3): 426–34.doi:10.1006/geno.1997.5069.PMID 9441746.
^"Entrez Gene: GPR39 G protein-coupled receptor 39".

Popovics P, Stewart AJ (2011)."GPR39: A Zn2+-activated G protein-coupled receptor that regulates pancreatic, gastrointestinal and neuronal functions".Cell. Mol. Life Sci.68(1): 85–95.doi:10.1007/s00018-010-0517-1.PMC11114682.PMID 20812023.S2CID 20170402.
Bonaldo MF, Lennon G, Soares MB (1997)."Normalization and subtraction: two approaches to facilitate gene discovery".Genome Res.6(9): 791–806.doi:10.1101/gr.6.9.791.PMID 8889548.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID 14702039.
Holst B, Holliday ND, Bach A, et al. (2005)."Common structural basis for constitutive activity of the ghrelin receptor family".J. Biol. Chem.279(51): 53806–17.doi:10.1074/jbc.M407676200.PMID 15383539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005)."Generation and annotation of the DNA sequences of human chromosomes 2 and 4".Nature.434(7034): 724–31.Bibcode:2005Natur.434..724H.doi:10.1038/nature03466.PMID 15815621.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID 16344560.
Holst B, Egerod KL, Schild E, et al. (2007)."GPR39 signaling is stimulated by zinc ions but not by obestatin".Endocrinology.148(1): 13–20.doi:10.1210/en.2006-0933.PMID 16959833.
Lauwers E, Landuyt B, Arckens L, et al. (2006). "Obestatin does not activate orphan G protein-coupled receptor GPR39".Biochem. Biophys. Res. Commun.351(1): 21–5.doi:10.1016/j.bbrc.2006.09.141.PMID 17054911.
Egerod KL, Holst B, Petersen PS, et al. (2007)."GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue".Mol. Endocrinol.21(7): 1685–98.doi:10.1210/me.2007-0055.PMID 17488974.
Yasuda S, Miyazaki T, Munechika K, et al. (2007). "Isolation of Zn2+ as an endogenous agonist of GPR39 from fetal bovine serum".J. Recept. Signal Transduct. Res.27(4): 235–46.doi:10.1080/10799890701506147.PMID 17885920.S2CID 33411716.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183840–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026343–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9441746-5] McKee KK, Tan CP, Palyha OC, Liu J, Feighner SD, Hreniuk DL, Smith RG, Howard AD, Van der Ploeg LH (Mar 1998). "Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors".Genomics.46(3): 426–34.doi:10.1006/geno.1997.5069.PMID 9441746.

[entrez-6] "Entrez Gene: GPR39 G protein-coupled receptor 39".

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References

Further reading