GPR85

GPR85
Identifiers
Aliases	GPR85,SREB, SREB2, G protein-coupled receptor 85
External IDs	OMIM:605188;MGI:1927851;HomoloGene:10355;GeneCards:GPR85;OMA:GPR85 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	113,087,778bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	13,839,941bp
RNA expressionpattern
	Top expressed in
	endothelial cell; ; caudate nucleus; ; primary visual cortex; ; putamen; ; dorsolateral prefrontal cortex; ; ganglionic eminence; ; prefrontal cortex; ; lateral nuclear group of thalamus; ; nucleus accumbens; ; Brodmann area 23;
	Top expressed in
	barrel cortex; ; Rostral migratory stream; ; Region I of hippocampus proper; ; piriform cortex; ; ventromedial nucleus; ; substantia nigra; ; temporal lobe; ; facial motor nucleus; ; lobe of cerebellum; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo/QuickGO
Orthologs
	54329
	64450
	ENSG00000164604
	ENSMUSG00000048216
	P60893
	P60894
	NM_001146265; NM_001146266; NM_001146267; NM_018970
	NM_145066; NM_001330666; NM_001330667
	NP_001139737; NP_001139738; NP_001139739; NP_061843
	NP_001317595; NP_001317596; NP_659503
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 85is aproteinthat in humans is encoded by theGPR85gene.^[5]^[6]^[7]

References[edit]

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000164604–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000048216–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hellebrand S, Schaller HC, Wittenberger T (Nov 2000). "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31".Biochim Biophys Acta.1493(1–2): 269–72.doi:10.1016/s0167-4781(00)00182-2.PMID 10978537.
^Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (Jul 2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system".Biochem Biophys Res Commun.272(2): 576–82.doi:10.1006/bbrc.2000.2829.PMID 10833454.
^"Entrez Gene: GPR85 G protein-coupled receptor 85".

Further reading[edit]

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999)."Toward a complete human genome sequence".Genome Res.8(11): 1097–108.doi:10.1101/gr.8.11.1097.PMID 9847074.
Hartley JL, Temple GF, Brasch MA (2001)."DNA cloning using in vitro site-specific recombination".Genome Res.10(11): 1788–95.doi:10.1101/gr.143000.PMC310948.PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001)."Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs".Genome Res.11(3): 422–35.doi:10.1101/gr.GR1547R.PMC311072.PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1(3): 287–92.doi:10.1093/embo-reports/kvd058.PMC1083732.PMID 11256614.
Jeon J, Kim C, Sun W, et al. (2002). "Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor".Biochem. Biophys. Res. Commun.298(4): 613–8.doi:10.1016/S0006-291X(02)02515-9.PMID 12408996.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003)."The DNA sequence of human chromosome 7".Nature.424(6945): 157–64.Bibcode:2003Natur.424..157H.doi:10.1038/nature01782.PMID 12853948.
Wiemann S, Arlt D, Huber W, et al. (2004)."From ORFeome to biology: a functional genomics pipeline".Genome Res.14(10B): 2136–44.doi:10.1101/gr.2576704.PMC528930.PMID 15489336.
Matsumoto M, Beltaifa S, Weickert CS, et al. (2005). "A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain".Brain Res. Mol. Brain Res.138(1): 58–69.doi:10.1016/j.molbrainres.2005.04.002.PMID 15893849.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Res.16(1): 55–65.doi:10.1101/gr.4039406.PMC1356129.PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34(Database issue): D415–8.doi:10.1093/nar/gkj139.PMC1347501.PMID 16381901.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164604–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048216–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978537-5] Hellebrand S, Schaller HC, Wittenberger T (Nov 2000). "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31".Biochim Biophys Acta.1493(1–2): 269–72.doi:10.1016/s0167-4781(00)00182-2.PMID 10978537.

[pmid10833454-6] Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, Tadokoro M, Matsumoto S, Ohishi T, Furuichi K (Jul 2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system".Biochem Biophys Res Commun.272(2): 576–82.doi:10.1006/bbrc.2000.2829.PMID 10833454.

[entrez-7] "Entrez Gene: GPR85 G protein-coupled receptor 85".

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See also[edit]

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Further reading[edit]