GPRC6A

GPRC6A
Identifiers
Aliases	GPRC6A,GPCR, bA86F4.3, G protein-coupled receptor class C group 6 member A
External IDs	OMIM:613572;MGI:2429498;HomoloGene:17529;GeneCards:GPRC6A;OMA:GPRC6A - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q22.1 Start 116,792,085bp End 116,829,083bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10|10 B3 Start 51,490,919bp End 51,507,557bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in testicle gonad salivary gland minor salivary glands islet of Langerhans human kidney right adrenal gland right adrenal cortex muscle of thigh left adrenal gland Top expressed in embryo embryo left lung lobe right lung lobe islet of Langerhans More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane cell surface plasma membrane intracellular anatomical structure membrane integral component of plasma membrane Biological process response to amino acid calcium-mediated signaling signal transduction G protein-coupled receptor signaling pathway Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 222545 210198 Ensembl ENSG00000173612 ENSMUSG00000019905 UniProt Q5T6X5 Q8K4Z6 RefSeq (mRNA) NM_148963 NM_001286354 NM_001286355 NM_153071 RefSeq (protein) NP_001273283 NP_001273284 NP_683766 NP_694711 Location (UCSC) Chr 6: 116.79 – 116.83 Mb Chr 10: 51.49 – 51.51 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

G protein-coupled receptor family C group 6 member A(GPRC6A) is aproteinthat in humans is encoded by theGPRC6Agene.This protein functions as a receptor ofL-α-amino acids,cations(e.g.,calcium),osteocalcin,andsteroids.It is amembrane androgen receptor.

Clinical significance

GPRC6A has also been linked toprostate cancerprogression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses totestosterone.

See also

• ZIP9

Further reading

• Harrington JJ, Sherf B, Rundlett S, Jackson PD, Perry R, Cain S, Leventhal C, Thornton M, Ramachandran R, Whittington J, Lerner L, Costanzo D, McElligott K, Boozer S, Mays R, Smith E, Veloso N, Klika A, Hess J, Cothren K, Lo K, Offenbacher J, Danzig J, Ducar M (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression".Nat. Biotechnol.19(5): 440–5.doi:10.1038/88107.PMID11329013.S2CID25064683.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence".FEBS Lett.520(1–3): 97–101.doi:10.1016/S0014-5793(02)02775-8.PMID12044878.S2CID7116392.
• Wellendorph P, Bräuner-Osborne H (2004). "Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor".Gene.335:37–46.doi:10.1016/j.gene.2004.03.003.PMID15194188.
• Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H (2005). "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids".Mol. Pharmacol.67(3): 589–97.doi:10.1124/mol.104.007559.PMID15576628.S2CID469049.
• Pi M, Faber P, Ekema G, Jackson PD, Ting A, Wang N, Fontilla-Poole M, Mays RW, Brunden KR, Harrington JJ, Quarles LD (2006)."Identification of a novel extracellular cation-sensing G-protein-coupled receptor".J. Biol. Chem.280(48): 40201–9.doi:10.1074/jbc.M505186200.PMC1435382.PMID16199532.

External links

• GPRC6A+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• "Calcium-Sensing Receptors: GPRC₆".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology.