Glutamate receptor delta-1 subunitalso known asGluD1orGluRδ1is a transmembrane protein[5][6](1009 aa) encoded by theGRID1gene.[7][8]A C-terminal GluD1 splicing isoform (896 aa) has been described based on mRNA analysis.[9]
Several genetic epidemiology studies have shown a strong association between several variants of theGRID1gene and increased risk of developingschizophrenia.[12][13]
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Yamazaki M, Araki K, Shibata A, Mishina M (March 1992). "Molecular cloning of a cDNA encoding a novel member of the mouse glutamate receptor channel family".Biochemical and Biophysical Research Communications.183(2): 886–92.doi:10.1016/0006-291X(92)90566-4.PMID1372507.
^Treadaway J, Zuo J (December 1998). "Mapping of the mouse glutamate receptor delta1 subunit (Grid1) to chromosome 14".Genomics.54(2): 359–60.doi:10.1006/geno.1998.5599.PMID9828146.
^Guo SZ, Huang K, Shi YY, Tang W, Zhou J, Feng GY, et al. (July 2007). "A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population".Schizophrenia Research.93(1–3): 385–90.doi:10.1016/j.schres.2007.03.007.PMID17490860.S2CID9497500.
^Treutlein J, Mühleisen TW, Frank J, Mattheisen M, Herms S, Ludwig KU, et al. (June 2009). "Dissection of phenotype reveals possible association between schizophrenia and Glutamate Receptor Delta 1 (GRID1) gene promoter".Schizophrenia Research.111(1–3): 123–30.doi:10.1016/j.schres.2009.03.011.PMID19346103.S2CID20949145.