GRIN2D

GRIN2D
Identifiers
Aliases	GRIN2D,EB11, GluN2D, NMDAR2D, NR2D, glutamate ionotropic receptor NMDA type subunit 2D, EIEE46, DEE46
External IDs	OMIM:602717;MGI:95823;HomoloGene:648;GeneCards:GRIN2D;OMA:GRIN2D - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 48,393,668bp End 48,444,931bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7 B3|7 29.54 cM Start 45,831,883bp End 45,878,378bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in cingulate gyrus anterior cingulate cortex prefrontal cortex ganglionic eminence hypothalamus ventricular zone right frontal lobe lateral nuclear group of thalamus amygdala dorsolateral prefrontal cortex Top expressed in molecular layer of cerebellar cortex lumbar subsegment of spinal cord molar primary visual cortex seminiferous tubule dorsomedial hypothalamic nucleus superior frontal gyrus spermatocyte dentate gyrus of hippocampal formation granule cell neural layer of retina More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ion channel activity protein binding extracellularly glutamate-gated ion channel activity ionotropic glutamate receptor activity NMDA glutamate receptor activity glutamate-gated calcium ion channel activity signaling receptor activity Cellular component integral component of membrane postsynaptic membrane membrane plasma membrane synapse cell junction intracellular anatomical structure integral component of plasma membrane NMDA selective glutamate receptor complex postsynaptic density membrane Biological process startle response regulation of sensory perception of pain adult locomotory behavior ion transport MAPK cascade ionotropic glutamate receptor signaling pathway excitatory postsynaptic potential calcium-mediated signaling calcium ion transmembrane import into cytosol regulation of molecular function brain development regulation of synaptic plasticity long-term potentiation excitatory chemical synaptic transmission Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2906 14814 Ensembl ENSG00000105464 ENSMUSG00000002771 UniProt O15399 Q03391 RefSeq (mRNA) NM_000836 NM_008172 RefSeq (protein) NP_000827 NP_032198 Location (UCSC) Chr 19: 48.39 – 48.44 Mb Chr 7: 45.83 – 45.88 Mb PubMedsearch
Wikidata
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Glutamate [NMDA] receptor subunit epsilon-4is aproteinthat in humans is encoded by theGRIN2Dgene.

Function

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D).

Interactions

GRIN2D has been shown tointeractwithInterleukin 16.

See also

• Glutamate receptor
• NMDA receptor

Further reading

• Schröder HC, Perovic S, Kavsan V, Ushijima H, Müller WE (1998). "Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death".Neurotoxicology.19(4–5): 683–8.PMID9745929.
• King JE, Eugenin EA, Buckner CM, Berman JW (2006)."HIV tat and neurotoxicity".Microbes Infect.8(5): 1347–57.doi:10.1016/j.micinf.2005.11.014.PMID16697675.
• Kornau HC, Schenker LT, Kennedy MB, Seeburg PH (1995). "Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95".Science.269(5231): 1737–40.Bibcode:1995Sci...269.1737K.doi:10.1126/science.7569905.PMID7569905.
• Magnuson DS, Knudsen BE, Geiger JD, Brownstone RM, Nath A (1995). "Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity".Ann. Neurol.37(3): 373–80.doi:10.1002/ana.410370314.PMID7695237.S2CID24405132.
• Lannuzel A, Lledo PM, Lamghitnia HO, Vincent JD, Tardieu M (1995). "HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons".Eur. J. Neurosci.7(11): 2285–93.doi:10.1111/j.1460-9568.1995.tb00649.x.PMID8563977.S2CID27201873.
• Corasaniti MT, Melino G, Navarra M, Garaci E, Finazzi-Agrò A, Nisticò G (1995). "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase".Neurodegeneration.4(3): 315–21.doi:10.1016/1055-8330(95)90021-7.PMID8581564.
• Akbarian S, Sucher NJ, Bradley D, Tafazzoli A, Trinh D, Hetrick WP, Potkin SG, Sandman CA, Bunney WE, Jones EG (1996)."Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics".J. Neurosci.16(1): 19–30.doi:10.1523/JNEUROSCI.16-01-00019.1996.PMC6578738.PMID8613785.
• Pittaluga A, Pattarini R, Severi P, Raiteri M (1996). "Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120".AIDS.10(5): 463–8.doi:10.1097/00002030-199605000-00003.PMID8724036.S2CID1669986.
• Wu P, Price P, Du B, Hatch WC, Terwilliger EF (1996). "Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons".NeuroReport.7(5): 1045–9.doi:10.1097/00001756-199604100-00018.PMID8804048.S2CID21018147.
• Bennett BA, Rusyniak DE, Hollingsworth CK (1995). "HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures".Brain Res.705(1–2): 168–76.doi:10.1016/0006-8993(95)01166-8.PMID8821747.S2CID32822686.
• Toggas SM, Masliah E, Mucke L (1996). "Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine".Brain Res.706(2): 303–7.doi:10.1016/0006-8993(95)01197-8.PMID8822372.S2CID44260060.
• Dreyer EB, Lipton SA (1995). "The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid".Eur. J. Neurosci.7(12): 2502–7.doi:10.1111/j.1460-9568.1995.tb01048.x.PMID8845955.S2CID7370984.
• Raber J, Toggas SM, Lee S, Bloom FE, Epstein CJ, Mucke L (1996)."Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase".Virology.226(2): 362–73.doi:10.1006/viro.1996.0664.PMID8955056.
• Scherzer CR,Landwehrmeyer GB,Kerner JA, Standaert DG, Hollingsworth ZR, Daggett LP, Veliçelebi G, Penney JB, Young AB (1997). "Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum".Neurobiol. Dis.4(1): 35–46.doi:10.1006/nbdi.1997.0136.PMID9258910.S2CID20991142.
• Hess SD, Daggett LP, Deal C, Lu CC, Johnson EC, Veliçelebi G (1998)."Functional characterization of human N-methyl-D-aspartate subtype 1A/2D receptors".J. Neurochem.70(3): 1269–79.doi:10.1046/j.1471-4159.1998.70031269.x.PMID9489750.S2CID22433867.
• Kurschner C, Mermelstein PG, Holden WT,Surmeier DJ(1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins".Mol. Cell. Neurosci.11(3): 161–72.doi:10.1006/mcne.1998.0679.PMID9647694.S2CID36534759.
• New DR, Maggirwar SB, Epstein LG, Dewhurst S, Gelbard HA (1998)."HIV-1 Tat induces neuronal death via tumor necrosis factor-alpha and activation of non-N-methyl-D-aspartate receptors by a NFkappaB-independent mechanism".J. Biol. Chem.273(28): 17852–8.doi:10.1074/jbc.273.28.17852.PMID9651389.

External links

• GRIN2D+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.