GRINL1A

POLR2M
Identifiers
Aliases	POLR2M,GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDs	OMIM:606485;MGI:107282;HomoloGene:9181;GeneCards:POLR2M;OMA:POLR2M - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q21.3 Start 57,706,695bp End 57,782,762bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 D|9 39.85 cM Start 71,385,719bp End 71,393,217bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in germinal epithelium muscle of thigh Achilles tendon tail of epididymis Skeletal muscle tissue of rectus abdominis secondary oocyte Epithelium of choroid plexus vena cava optic nerve biceps brachii Top expressed in somite mandibular prominence hand tail of embryo genital tubercle maxillary prominence muscle of thigh foot abdominal wall choroid plexus of fourth ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-directed 5'-3' RNA polymerase activity protein binding Cellular component RNA polymerase II, holoenzyme neuronal cell body nuclear envelope nucleus cytoplasm cell junction plasma membrane Z discdkac cytoskeleton membrane I band cortical actin cytoskeleton extrinsic component of cytoplasmic side of plasma membrane intracellular anatomical structure Biological process maintenance of ER location RNA biosynthetic process intracellular signal transduction Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 81488 28015 Ensembl ENSG00000255529 ENSMUSG00000032199 UniProt P0CAP2 Q6EEV4 P0CAP1 Q6P6I6 RefSeq (mRNA) NM_001018102 NM_015532 NM_001164793 NM_178602 RefSeq (protein) NP_001018112 NP_056347 NP_001018112.1 NP_056347.1 NP_001018110 NP_689664 NP_001158265 NP_848717 Location (UCSC) Chr 15: 57.71 – 57.78 Mb Chr 9: 71.39 – 71.39 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

GRINL1A complex locus protein 1is aproteinthat in humans is encoded by theGRINL1Agene.

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.

See also

• NMDA receptor

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
• Hartley JL, Temple GF, Brasch MA (2001)."DNA cloning using in vitro site-specific recombination".Genome Res.10(11): 1788–95.doi:10.1101/gr.143000.PMC310948.PMID11076863.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing".EMBO Rep.1(3): 287–92.doi:10.1093/embo-reports/kvd058.PMC1083732.PMID11256614.
• Roginski RS, Mohan Raj BK, Finkernagel SW, Sciorra LJ (2001). "Assignment of an ionotropic glutamate receptor-like gene (GRINL1A) to human chromosome 15q22.1 by in situ hybridization".Cytogenet. Cell Genet.93(1–2): 143–4.doi:10.1159/000056971.PMID11474202.S2CID45209253.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Roginski RS, Mohan Raj BK, Birditt B, Rowen L (2005). "The human GRINL1A gene defines a complex transcription unit, an unusual form of gene organization in eukaryotes".Genomics.84(2): 265–76.doi:10.1016/j.ygeno.2004.04.004.PMID15233991.
• Wiemann S, Arlt D, Huber W, et al. (2004)."From ORFeome to biology: a functional genomics pipeline".Genome Res.14(10B): 2136–44.doi:10.1101/gr.2576704.PMC528930.PMID15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature.437(7062): 1173–8.Bibcode:2005Natur.437.1173R.doi:10.1038/nature04209.PMID16189514.S2CID4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34(Database issue): D415–8.doi:10.1093/nar/gkj139.PMC1347501.PMID16381901.

External links

• GRINL1A+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)