GSTP1
Glutathione S-transferase Pis anenzymethat in humans is encoded by theGSTP1gene.[4][5]
Function
[edit]Glutathione S-transferases(GSTs) are a family of enzymes that play an important role in detoxification by catalyzing the conjugation of manyhydrophobicand electrophilic compounds with reducedglutathione.Based on their biochemical, immunologic, and structural properties, the soluble GSTs are categorized into four main classes: alpha, mu, pi, and theta. The glutathione S-transferase pi gene (GSTP1) is a polymorphic gene encoding active, functionally different GSTP1 variant proteins that are thought to function inxenobiotic metabolismand play a role in susceptibility tocancer,and other diseases.[6]
Interactions
[edit]GSTP1 has been shown tointeractwithFanconi anemia, complementation group C[7][8]andMAPK8.[9]
GST-Pi is expressed in many human tissues, particularly in the biliary tree, renal distal convoluted tubules and lungs.[10]
Possible drug target
[edit]Triple-negative breast cancercells rely on glutathione-S-transferase Pi1, and inhibitors are being studied.[11]Piperlonguminehas been found to silence the gene.[12]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000084207–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Bora PS, Bora NS, Wu XL, Lange LG (October 1991)."Molecular cloning, sequencing, and expression of human myocardial fatty acid ethyl ester synthase-III cDNA".J. Biol. Chem.266(25): 16774–7.doi:10.1016/S0021-9258(18)55367-9.PMID1885604.
- ^Smith CM, Bora PS, Bora NS, Jones C, Gerhard DS (November 1995). "Genetic and radiation-reduced somatic cell hybrid sublocalization of the human GSTP1 gene".Cytogenet. Cell Genet.71(3): 235–9.doi:10.1159/000134117.PMID7587384.
- ^"Entrez Gene: GSTP1 glutathione S-transferase pi".
- ^Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ, Buchwald M (July 2001). "Fanconi anemia group C protein prevents apoptosis in hematopoietic cells through redox regulation of GSTP1".Nat. Med.7(7): 814–20.doi:10.1038/89937.PMID11433346.S2CID35177844.
- ^Reuter TY, Medhurst AL, Waisfisz Q, Zhi Y, Herterich S, Hoehn H, Gross HJ, Joenje H, Hoatlin ME, Mathew CG, Huber PA (October 2003). "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport".Exp. Cell Res.289(2): 211–21.doi:10.1016/S0014-4827(03)00261-1.PMID14499622.
- ^Wang T, Arifoglu P, Ronai Z, Tew KD (15 June 2001)."Glutathione S-transferase P1-1 (GSTP1-1) inhibits c-Jun N-terminal kinase (JNK1) signaling through interaction with the C terminus".J. Biol. Chem.276(24): 20999–1003.doi:10.1074/jbc.M101355200.PMID11279197.
- ^Terrier, P; Townsend, AJ; Coindre, JM; Triche, TJ; Cowan, KH (October 1990)."An immunohistochemical study of pi class glutathione S-transferase expression in normal human tissue".The American Journal of Pathology.137(4): 845–53.PMC1877535.PMID1977319.
- ^Triple-negative breast cancer target is found. May 2016
- ^"Researchers uncover mechanism for cancer-killing properties of pepper plant".
Further reading
[edit]- Strange RC, Fryer AA (1999). "The glutathione S-transferases: influence of polymorphism on cancer susceptibility".IARC Sci. Publ.(148): 231–49.PMID10493261.
- Kellen E, Hemelt M, Broberg K, Golka K, Kristensen VN, Hung RJ, Matullo G, Mittal RD, Porru S, Povey A, Schulz WA, Shen J, Buntinx F, Zeegers MP, Taioli E (2007)."Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review".Am. J. Epidemiol.165(11): 1221–30.doi:10.1093/aje/kwm003.PMID17404387.
- Sekine I, Minna JD, Nishio K, Tamura T, Saijo N (2006). "A literature review of molecular markers predictive of clinical response to cytotoxic chemotherapy in patients with lung cancer".J Thorac Oncol.1(1): 31–7.doi:10.1097/01243894-200601000-00008.PMID17409824.