Genome informatics
Genome Informatics(alsogenoinformaticsorgenetic information processing)[1]is a scientific study ofinformation processingingenomes.
Introduction[edit]
Information processing and information flow occur in the course of an organism's development and throughout its lifespan.[2]The essence of computation is information processing, and the essence of biological information processing is control of the molecular events inside a cell.[3]Genome informatics introducescomputationaltechniques and applies them to derive information from genome sequences.[4]Genome informatics includes methods to analyzeDNAsequence information and to predictproteinsequence and structure.[4]Methods of studying a large genomic data include variant-calling, transcriptomic analysis, and variant interpretation.[5]Genome informatics can analyzeDNAsequence information and to predictproteinsequence and structure.[4]Genome informatics dealing with[6]microbial and metagenomics,sequencing algorithms,variant discovery and genome assembly, evolution, complex traits and phylogenetics, personal and medical genomics, transcriptomics, genome structure and function.[6]Genoinformatics refers to genome and chromosome dynamics,quantitative biologyand modeling, molecular and cellular pathologies.[7]Genome informatics also includes the field of genome design. There still a lot more we can do and develop in Genome Informatics. Find a potential disease, searching a solution for a disease, or proving why people get sick for no reason. For genomic informatics there are several main applications for it, including:
- genome information analysis[8]
- computational modelling of gene regulatory networks[9]
- models for complex eukaryotic regulatory DNA sequences[9]
- an algorithm forAb InitioDNA Motif Detection[9]
Applications[edit]
Biomolecular systems that can process information are sought for computational applications, because of their potential for parallelism and miniaturization and because their biocompatibility also makes them suitable for future biomedical applications. DNA has been used to design machines, motors, finite automata, logic gates, reaction networks and logic programs, amongst many other structures and dynamic behaviours.[10]
See also[edit]
References[edit]
- ^Patel, A. (2001)."Why genetic information processing could have a quantum basis".Journal of Biosciences.26(2): 145–151.arXiv:quant-ph/0105001.Bibcode:2001quant.ph..5001P.doi:10.1007/BF02703638.ISSN0250-5991.PMID11426050.S2CID12348859.
- ^Bajic, Vladimir B; Wee, Tan Tin (2005)."Information Processing and Living Systems".Series on Advances in Bioinformatics and Computational Biology.2.doi:10.1142/p391.ISBN978-1-86094-563-2.ISSN1751-6404.
- ^Wills, Peter R. (2016-03-13)."DNA as information".Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.374(2063): 20150417.Bibcode:2016RSPTA.37450417W.doi:10.1098/rsta.2015.0417.hdl:2292/33048.PMID26857666.
- ^abc"Genome informatics - Latest research and news | Nature".www.nature.com.Retrieved2020-04-20.
- ^"Genome Informatics (Virtual Conference)".Wellcome Genome Campus Advanced Courses and Scientific Conferences.Archived fromthe originalon 2021-02-27.Retrieved2020-11-14.
- ^ab"Genome Informatics | CSHL".meetings.cshl.edu.Retrieved2020-04-20.
- ^"ePole of GenoInformatics".www.ijm.fr(in French). Archived fromthe originalon 2022-01-08.Retrieved2020-04-21.
- ^Human genome informatics: translating genes into health.Lambert, Christophe G., Baker, Darrol J., Patrinos, George P. London, United Kingdom. 2 August 2018.ISBN978-0-12-813431-3.OCLC1047959760.
{{cite book}}:CS1 maint: location missing publisher (link) CS1 maint: others (link) - ^abcBajic, Vladimir B; Wee, Tan Tin (2005)."Information Processing and Living Systems".Series on Advances in Bioinformatics and Computational Biology.2.doi:10.1142/p391.ISBN978-1-86094-563-2.ISSN1751-6404.
- ^Santini, Cristina Costa; Bath, Jonathan; Turberfield, Andrew J.; Tyrrell, Andy M. (2012-04-23)."A DNA Network as an Information Processing System".International Journal of Molecular Sciences.13(4): 5125–5137.doi:10.3390/ijms13045125.ISSN1422-0067.PMC3344270.PMID22606034.
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