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Gevotroline

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Gevotroline
Clinical data
Routes of
administration		Oral
ATC code
  • None
Legal status
Legal status
  • In general: uncontrolled
Identifiers
  • 8-fluoro-2-(3-pyridin-3-ylpropyl)-1,3,4,5-tetrahydropyrido[4,3-b]indole
CAS Number
PubChemCID
ChemSpider
UNII
ChEBI
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC19H20FN3
Molar mass309.388g·mol−1
3D model (JSmol)
  • Fc2cc1c3c([nH]c1cc2)CCN(C3)CCCc4cccnc4

Gevotroline(WY-47,384) is anatypical antipsychoticwith atricyclicstructurewhich was under development for the treatment ofschizophreniabyWyeth-Ayerst.[1][2][3]It acts as a balanced, modestaffinityD2and5-HT2receptorantagonistand also possesses highaffinityfor thesigma receptor.[2][4][5][6]It was well tolerated and showed efficacy inphase IIclinical trialsbut was never marketed.[2][3]

See also

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References

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  1. ^Triggle DJ (1996).Dictionary of Pharmacological Agents.Boca Raton: Chapman & Hall/CRC.ISBN0-412-46630-9.
  2. ^abcAbou-Gharbia M, Moyer JA (1990). Bristol JA (ed.)."Novel Antipyschotic Agents".Annual Reports in Medicinal Chemistry.25.Boston: Academic Press: 1–10.doi:10.1016/S0065-7743(08)61577-8.ISBN0-12-040525-3.
  3. ^abJackson DM, Mohell N (1996)."A Review of the Pharmacology of New Antipsychotic Drugs".In Stone TW (ed.).CNS neurotransmitters and neuromodulators: dopamine.Boca Raton: CRC Press.ISBN0-8493-7632-7.
  4. ^Snyder SH, Largent BL (1989). "Receptor mechanisms in antipsychotic drug action: focus on sigma receptors".The Journal of Neuropsychiatry and Clinical Neurosciences.1(1): 7–15.doi:10.1176/jnp.1.1.7.PMID2577720.
  5. ^Matheson GK, Guthrie D, Bauer C, Knowles A, White G, Ruston C (January 1991). "Sigma receptor ligands alter concentrations of corticosterone in plasma in the rat".Neuropharmacology.30(1): 79–87.doi:10.1016/0028-3908(91)90046-E.PMID1675451.S2CID29702968.
  6. ^Gudelsky GA, Nash JF (February 1992). "Neuroendocrinological and neurochemical effects of sigma ligands".Neuropharmacology.31(2): 157–162.doi:10.1016/0028-3908(92)90026-L.PMID1348112.S2CID36585024.
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