Gluconokinase
| gluconokinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Gluconokinase homodimer, E.Coli | |||||||||
| Identifiers | |||||||||
| EC no. | 2.7.1.12 | ||||||||
| CAS no. | 9030-55-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDBstructures | RCSB PDBPDBePDBsum | ||||||||
| Gene Ontology | AmiGO/QuickGO | ||||||||
| |||||||||
Inenzymology,agluconokinase(EC2.7.1.12) is anenzymethatcatalyzesthechemical reaction
- ATP + D-gluconateADP + 6-phospho-D-gluconate
Thus, the twosubstratesof this enzyme areATPandD-gluconate,whereas its twoproductsareADPand6-phospho-D-gluconate.
This enzyme belongs to the family oftransferases,specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. Thesystematic nameof this enzyme class isATP:D-gluconate 6-phosphotransferase.Other names in common use includegluconokinase (phosphorylating),andgluconate kinase.This enzyme participates inpentose phosphate pathway.
Structural studies
[edit]As of late 2007, 6structureshave been solved for this class of enzymes, withPDBaccession codes1KNQ,1KO1,1KO4,1KO5,1KO8,and1KOF.
References
[edit]- COHEN SS (1951)."Gluconokinase and the oxidative path of glucose-6-phosphate utilization".J. Biol. Chem.189(2): 617–28.doi:10.1016/S0021-9258(18)44878-8.PMID14832279.
- LEDER IG (1957)."Hog kidney gluconokinase".J. Biol. Chem.225(1): 125–36.doi:10.1016/S0021-9258(18)64915-4.PMID13416223.
- Narrod SA; Wood WA (1956)."Carbohydrate oxidation by Pseudomonas fluorescens. V. Evidence for gluconokinase and 2-ketogluconokinase".J. Biol. Chem.220(1): 45–55.doi:10.1016/S0021-9258(18)65331-1.PMID13319325.
- SABLE HZ, GUARINO AJ (1952)."Phosphorylation of gluconate in yeast extracts".J. Biol. Chem.196(1): 395–402.doi:10.1016/S0021-9258(18)55743-4.PMID12980980.
