Guanoclor
Appearance
![]() | |
Clinical data | |
---|---|
ATC code | |
Identifiers | |
| |
CAS Number | |
PubChemCID | |
ChemSpider | |
UNII | |
CompTox Dashboard(EPA) | |
ECHA InfoCard | 100.023.334 |
Chemical and physical data | |
Formula | C9H12Cl2N4O |
Molar mass | 263.12g·mol−1 |
3D model (JSmol) | |
| |
| |
(verify) |
Guanoclor(INN), also known asguanochlor,is asympatholyticdrug. It is known to bind to non-adrenergic sites in pig kidney membranes.[1]
Synthesis
[edit]When β-(2,6-dichlorophenoxy)ethyl bromide (1) is reacted with hydrazine to give2,and this is reacted withS-methylthiourea,guanochlor (3) results.[2][3]
![](https://upload.wikimedia.org/wikipedia/commons/thumb/5/54/Guanochlor_synthesis.svg/700px-Guanochlor_synthesis.svg.png)
References
[edit]- ^Vigne P, Lazdunski M, Frelin C (January 1989). "Guanabenz, guanochlor, guanoxan and idazoxan bind with high affinity to non-adrenergic sites in pig kidney membranes".European Journal of Pharmacology.160(2): 295–8.doi:10.1016/0014-2999(89)90503-7.PMID2527160.
- ^Durant GJ, Smith GM, Spickett RG, Wright SH (January 1966). "Biologically active guanidines and related compounds. II. Some antiinflammatory aminoguanidines".Journal of Medicinal Chemistry.9(1): 22–7.doi:10.1021/jm00319a005.PMID5958955.
- ^Prepn of free base and sulfate:BE 629613(1963 toPfizer), C.A. 60, 14437d (1964).