HDAC1
Histone deacetylase 1(HDAC1) is anenzymethat in humans is encoded by theHDAC1gene.[5]
Function[edit]
Histone acetylation and deacetylation,catalyzed by multisubunit complexes, play a key role in the regulation ofeukaryoticgene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2MTA2,it deacetylatesp53and modulates its effect on cell growth and apoptosis.[6]
Interactions[edit]
HDAC1 has been shown tointeractwith:
- Androgen receptor,[7]
- BCL6,[8][9]
- BTG2,[10][11]
- BUB1B,[12]
- BUB1,[12]
- BUB3,[12]
- CBFA2T3,[13][14]
- CDC20,[12]
- CDH1,[12]
- CHD3,[15][16]
- CHD4,[15][17][18]
- COUP-TFII,[19]
- CTBP1,[20][21][22]
- DDX17,[23]
- DDX5,[23]
- DNMT3A,[24]
- DNMT3L,[25][26]
- Death-associated protein 6,[27]
- EED,[28]
- EVI1,[29][30]
- EZH2,[28]
- FKBP3,[31]
- GATA1,[32]
- HMG20B,[33]
- HSPA4,[34]
- HUS1,[35]
- Histone deacetylase 2,[15][17][28][33][34][36][37][38][39][40][41][42][43]
- Homeobox protein TGIF1,[20][44]
- Host cell factor C1,[45]
- IFRD1,[46]
- IKZF1,[47][48]
- ING1,[16][49]
- MBD3,[41][50][51]
- MIER1,[52]
- MLL,[53]
- MTA1,[17][54]
- MTA2,[17][41][55][56]
- Mad1,[12]
- Mdm2,[57]
- Methyl-CpG-binding domain protein 2,[41][58][59]
- Mothers against decapentaplegic homolog 2,[60]
- MyoD,[61][62]
- NFKB1,[63]
- Nuclear receptor co-repressor 2,[36][64]
- P21,[65]
- PCNA,[66]
- PHF21A,[33][67]
- Prohibitin,[68][69]
- Promyelocytic leukemia protein,[70][71]
- RAD9A,[35]
- RBBP4,[17][18][41][42][43][55][58][72][73][74][75]
- RBBP7,[17][41][43][58]
- RCOR1,[33][55]
- RELA,[40][63][76]
- RFC1,[77]
- Retinoblastoma protein,[61][69][78][79][80][81][82]
- Retinoblastoma-like protein 1,[78][79]
- Retinoblastoma-like protein 2,[78][83]
- SAP30,[16][41][84][85][86][87]
- SATB1,[56]
- SIN3A,[15][16][17][18][41][42][55][56][72][73][88][89][90][91]
- SIN3B,[41][47]
- SPEN,[92]
- SUDS3,[88][93]
- SUV39H1,[94]
- Sp1 transcription factor,[73][95][96][97]
- TOP2A,[98][99]
- TOP2B,[98][99]and
- Zinc finger and BTB domain-containing protein 16.[8][100][101]
See also[edit]
References[edit]
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Further reading[edit]
- Wolffe AP (April 1996)."Histone deacetylase: a regulator of transcription".Science.272(5260): 371–2.Bibcode:1996Sci...272..371W.doi:10.1126/science.272.5260.371.PMID8602525.S2CID27257723.
- Ahringer J (August 2000). "NuRD and SIN3 histone deacetylase complexes in development".Trends in Genetics.16(8): 351–6.doi:10.1016/S0168-9525(00)02066-7.PMID10904264.
- Verdin E, Dequiedt F, Kasler HG (May 2003). "Class II histone deacetylases: versatile regulators".Trends in Genetics.19(5): 286–93.doi:10.1016/S0168-9525(03)00073-8.hdl:2268/80861.PMID12711221.
- Zhang Y, Dufau ML (June 2003)."Dual mechanisms of regulation of transcription of luteinizing hormone receptor gene by nuclear orphan receptors and histone deacetylase complexes".The Journal of Steroid Biochemistry and Molecular Biology.85(2–5): 401–14.doi:10.1016/S0960-0760(03)00230-9.PMID12943729.S2CID28512341.
- Stevens M, De Clercq E, Balzarini J (September 2006)."The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention".Medicinal Research Reviews.26(5): 595–625.doi:10.1002/med.20081.PMC7168390.PMID16838299.
- Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (June 1995)."E2F-5, a new E2F family member that interacts with p130 in vivo".Molecular and Cellular Biology.15(6): 3082–9.doi:10.1128/mcb.15.6.3082.PMC230539.PMID7760804.
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- Margolis DM, Somasundaran M, Green MR (February 1994)."Human transcription factor YY1 represses human immunodeficiency virus type 1 transcription and virion production".Journal of Virology.68(2): 905–10.doi:10.1128/JVI.68.2.905-910.1994.PMC236527.PMID8289393.
- Furukawa Y, Kawakami T, Sudo K, Inazawa J, Matsumine A, Akiyama T, Nakamura Y (1996). "Isolation and mapping of a human gene (RPD3L1) that is homologous to RPD3, a transcription factor in Saccharomyces cerevisiae".Cytogenetics and Cell Genetics.73(1–2): 130–3.doi:10.1159/000134323.PMID8646880.
- Hassig CA, Fleischer TC, Billin AN, Schreiber SL, Ayer DE (May 1997)."Histone deacetylase activity is required for full transcriptional repression by mSin3A".Cell.89(3): 341–7.doi:10.1016/S0092-8674(00)80214-7.PMID9150133.S2CID14233219.
- Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN (May 1997)."Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression".Cell.89(3): 349–56.doi:10.1016/S0092-8674(00)80215-9.PMID9150134.S2CID13490886.
- Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May 1997)."Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex".Cell.89(3): 357–64.doi:10.1016/S0092-8674(00)80216-0.PMID9150135.
- Romerio F, Gabriel MN, Margolis DM (December 1997)."Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF".Journal of Virology.71(12): 9375–82.doi:10.1128/JVI.71.12.9375-9382.1997.PMC230241.PMID9371597.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene.200(1–2): 149–56.doi:10.1016/S0378-1119(97)00411-3.PMID9373149.
- Brehm A, Miska EA, McCance DJ, Reid JL, Bannister AJ, Kouzarides T (February 1998). "Retinoblastoma protein recruits histone deacetylase to repress transcription".Nature.391(6667): 597–601.Bibcode:1998Natur.391..597B.doi:10.1038/35404.PMID9468139.S2CID4326464.
- Magnaghi-Jaulin L, Groisman R, Naguibneva I, Robin P, Lorain S, Le Villain JP, Troalen F, Trouche D, Harel-Bellan A (February 1998). "Retinoblastoma protein represses transcription by recruiting a histone deacetylase".Nature.391(6667): 601–5.Bibcode:1998Natur.391..601M.doi:10.1038/35410.PMID9468140.S2CID4315457.
- Lin RJ, Nagy L, Inoue S, Shao W, Miller WH, Evans RM (February 1998)."Role of the histone deacetylase complex in acute promyelocytic leukaemia".Nature.391(6669): 811–4.Bibcode:1998Natur.391..811L.doi:10.1038/35895.PMID9486654.S2CID4383951.
- Luo RX, Postigo AA, Dean DC (February 1998)."Rb interacts with histone deacetylase to repress transcription".Cell.92(4): 463–73.doi:10.1016/S0092-8674(00)80940-X.PMID9491888.S2CID18857544.
External links[edit]
- HDAC1+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
