HOXD3
Homeobox protein Hox-D3is aproteinthat in humans is encoded by theHOXD3gene.[5][6][7]
Function[edit]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes.[7]
See also[edit]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000128652–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000079277–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes".Genomics.7(3): 460.doi:10.1016/0888-7543(90)90186-X.PMID1973146.
- ^Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature".Cell.71(4): 551–3.doi:10.1016/0092-8674(92)90588-4.PMID1358459.S2CID13370372.
- ^ab"Entrez Gene: HOXD3 homeobox D3".
Further reading[edit]
- Taniguchi Y, Fujii A, Moriuchi T (Oct 1992). "Cloning and sequencing of the human homeobox gene HOX4A".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1132(3): 332–4.doi:10.1016/0167-4781(92)90173-w.PMID1358204.
- Magli MC, Barba P, Celetti A, De Vita G, Cillo C, Boncinelli E (Jul 1991)."Coordinate regulation of HOX genes in human hematopoietic cells".Proceedings of the National Academy of Sciences of the United States of America.88(14): 6348–52.Bibcode:1991PNAS...88.6348M.doi:10.1073/pnas.88.14.6348.PMC52080.PMID1712489.
- Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E (Dec 1989)."The human HOX gene family".Nucleic Acids Research.17(24): 10385–402.doi:10.1093/nar/17.24.10385.PMC335308.PMID2574852.
- Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A (1990). "Organization of human class I homeobox genes".Genome.31(2): 745–56.doi:10.1139/g89-133.PMID2576652.
- Cannizzaro LA, Croce CM, Griffin CA, Simeone A, Boncinelli E, Huebner K (Jul 1987)."Human homeo box-containing genes located at chromosome regions 2q31----2q37 and 12q12----12q13".American Journal of Human Genetics.41(1): 1–15.PMC1684175.PMID2886047.
- Taniguchi Y, Komatsu N, Moriuchi T (May 1995)."Overexpression of the HOX4A (HOXD3) homeobox gene in human erythroleukemia HEL cells results in altered adhesive properties".Blood.85(10): 2786–94.doi:10.1182/blood.V85.10.2786.bloodjournal85102786.PMID7742539.
- Guazzi S, Lonigro R, Pintonello L, Boncinelli E, Di Lauro R, Mavilio F (Jul 1994)."The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins".The EMBO Journal.13(14): 3339–47.doi:10.1002/j.1460-2075.1994.tb06636.x.PMC395231.PMID7913891.
- Manley NR, Capecchi MR (Mar 1998)."Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands".Developmental Biology.195(1): 1–15.doi:10.1006/dbio.1997.8827.PMID9520319.
- Del Campo M, Jones MC, Veraksa AN, Curry CJ, Jones KL, Mascarello JT, Ali-Kahn-Catts Z, Drumheller T, McGinnis W (Jul 1999)."Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster".American Journal of Human Genetics.65(1): 104–10.doi:10.1086/302467.PMC1378080.PMID10364522.
- Myers C, Charboneau A, Boudreau N (Jan 2000)."Homeobox B3 promotes capillary morphogenesis and angiogenesis".The Journal of Cell Biology.148(2): 343–51.doi:10.1083/jcb.148.2.343.PMC2174277.PMID10648567.
- Limongi MZ, Pelliccia F, Gaddini L, Rocchi A (2000). "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31-->q32.1".Cytogenetics and Cell Genetics.90(1–2): 151–3.doi:10.1159/000015651.PMID11060466.S2CID35579702.
- Kosaki K, Kosaki R, Suzuki T, Yoshihashi H, Takahashi T, Sasaki K, Tomita M, McGinnis W, Matsuo N (Feb 2002). "Complete mutation analysis panel of the 39 human HOX genes".Teratology.65(2): 50–62.doi:10.1002/tera.10009.PMID11857506.
- Okubo Y, Hamada J, Takahashi Y, Tada M, Tsutsumida A, Furuuchi K, Aoyama T, Sugihara T, Moriuchi T (2002). "Transduction of HOXD3-antisense into human melanoma cells results in decreased invasive and motile activities".Clinical & Experimental Metastasis.19(6): 503–11.doi:10.1023/A:1020346211686.PMID12405287.S2CID2728036.
- Boudreau NJ, Varner JA (Feb 2004)."The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis".The Journal of Biological Chemistry.279(6): 4862–8.doi:10.1074/jbc.M305190200.PMID14610084.
- Hansen SL, Myers CA, Charboneau A, Young DM, Boudreau N (Dec 2003)."HoxD3 accelerates wound healing in diabetic mice".The American Journal of Pathology.163(6): 2421–31.doi:10.1016/S0002-9440(10)63597-3.PMC1892363.PMID14633614.
- Chen Y, Xu B, Arderiu G, Hashimoto T, Young WL, Boudreau N, Yang GY (Nov 2004)."Retroviral delivery of homeobox D3 gene induces cerebral angiogenesis in mice".Journal of Cerebral Blood Flow and Metabolism.24(11): 1280–7.doi:10.1097/01.WCB.0000141770.09022.AB.PMID15545924.
External links[edit]
- HOXD3+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.