Histone deacetylase 5
Histone deacetylase 5is anenzymethat in humans is encoded by theHDAC5gene.[5][6][7]
Function
[edit]Histonesplay a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alterschromosomestructure and affectstranscription factoraccess to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesseshistone deacetylaseactivity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.[7]
AMP-activated protein kinaseregulation of the glucose transporterGLUT4occurs byphosphorylationof HDAC5.[8]
HDAC5 is involved inmemory consolidationand suggests that development of more selectiveHDAC inhibitorsfor the treatment ofAlzheimer's diseaseshould avoid targeting HDAC5.[9]Its function can be effectively examined by siRNA knockdown based on an independent validation.[10]
HDAC5 overexpression inurothelialcarcinoma cell lines inhibits long-term proliferation but can promote epithelial-to-mesenchymal transition (EMT)[11]
Interactions
[edit]Histone deacetylase 5 has been shown tointeractwith:
See also
[edit]References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000108840–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000008855–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^abGrozinger CM, Hassig CA, Schreiber SL (April 1999)."Three proteins define a class of human histone deacetylases related to yeast Hda1p".Proceedings of the National Academy of Sciences of the United States of America.96(9): 4868–73.Bibcode:1999PNAS...96.4868G.doi:10.1073/pnas.96.9.4868.PMC21783.PMID10220385.
- ^Scanlan MJ, Chen YT, Williamson B, Gure AO, Stockert E, Gordan JD, et al. (May 1998). "Characterization of human colon cancer antigens recognized by autologous antibodies".International Journal of Cancer.76(5): 652–8.doi:10.1002/(SICI)1097-0215(19980529)76:5<652::AID-IJC7>3.0.CO;2-P.PMID9610721.S2CID916155.
- ^ab"Entrez Gene: HDAC5 histone deacetylase 5".
- ^McGee SL, van Denderen BJ, Howlett KF, Mollica J, Schertzer JD, Kemp BE, Hargreaves M (April 2008)."AMP-activated protein kinase regulates GLUT4 transcription by phosphorylating histone deacetylase 5".Diabetes.57(4): 860–7.doi:10.2337/db07-0843.PMID18184930.S2CID17274354.
- ^Agis-Balboa RC, Pavelka Z, Kerimoglu C, Fischer A (January 2013). "Loss of HDAC5 impairs memory function: implications for Alzheimer's disease".Journal of Alzheimer's Disease.33(1): 35–44.doi:10.3233/JAD-2012-121009.hdl:2434/223089.PMID22914591.
- ^Munkácsy G, Sztupinszki Z, Herman P, Bán B, Pénzváltó Z, Szarvas N, Győrffy B (September 2016)."Validation of RNAi Silencing Efficiency Using Gene Array Data shows 18.5% Failure Rate across 429 Independent Experiments".Molecular Therapy: Nucleic Acids.5(9): e366.doi:10.1038/mtna.2016.66.PMC5056990.PMID27673562.
- ^Jaguva Vasudevan AA, Hoffmann MJ, Beck ML, Poschmann G, Petzsch P, Wiek C, et al. (April 2019)."HDAC5 Expression in Urothelial Carcinoma Cell Lines Inhibits Long-Term Proliferation but Can Promote Epithelial-to-Mesenchymal Transition".International Journal of Molecular Sciences.20(9): 2135.doi:10.3390/ijms20092135.PMC6539474.PMID31052182.
- ^abLemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002)."Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor".The Journal of Biological Chemistry.277(24): 22045–52.doi:10.1074/jbc.M201736200.PMID11929873.
- ^Zhang CL, McKinsey TA, Olson EN (October 2002)."Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation".Molecular and Cellular Biology.22(20): 7302–12.doi:10.1128/MCB.22.20.7302-7312.2002.PMC139799.PMID12242305.
- ^Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. (December 2003). "Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation".Oncogene.22(57): 9176–84.doi:10.1038/sj.onc.1206902.PMID14668799.S2CID24491249.
- ^abZhang J, Kalkum M, Chait BT, Roeder RG (March 2002)."The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2".Molecular Cell.9(3): 611–23.doi:10.1016/S1097-2765(02)00468-9.PMID11931768.
- ^Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR".Molecular Cell.9(1): 45–57.doi:10.1016/S1097-2765(01)00429-4.hdl:11858/00-001M-0000-002C-9FF9-9.PMID11804585.
- ^Grozinger CM, Schreiber SL (July 2000)."Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization".Proceedings of the National Academy of Sciences of the United States of America.97(14): 7835–40.Bibcode:2000PNAS...97.7835G.doi:10.1073/pnas.140199597.PMC16631.PMID10869435.
- ^Koipally J, Georgopoulos K (August 2002)."A molecular dissection of the repression circuitry of Ikaros".The Journal of Biological Chemistry.277(31): 27697–705.doi:10.1074/jbc.M201694200.PMID12015313.
- ^Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000)."mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity".The Journal of Biological Chemistry.275(20): 15594–9.doi:10.1074/jbc.M908437199.PMID10748098.
- ^Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, et al. (2004)."Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition".Nucleic Acids Research.32(6): 1957–66.doi:10.1093/nar/gkh524.PMC390375.PMID15060175.
- ^abHuang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000)."Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway".Genes & Development.14(1): 45–54.doi:10.1101/gad.14.1.45.PMC316335.PMID10640275.
- ^Vega RB, Harrison BC, Meadows E, Roberts CR, Papst PJ, Olson EN, McKinsey TA (October 2004)."Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5".Molecular and Cellular Biology.24(19): 8374–85.doi:10.1128/MCB.24.19.8374-8385.2004.PMC516754.PMID15367659.
- ^Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard LL, Mishal Z, et al. (November 2004). "HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF".Oncogene.23(54): 8777–84.doi:10.1038/sj.onc.1208128.PMID15467736.S2CID26092755.
Further reading
[edit]- Verdin E, Dequiedt F, Kasler HG (May 2003)."Class II histone deacetylases: versatile regulators"(PDF).Trends in Genetics.19(5): 286–93.doi:10.1016/S0168-9525(03)00073-8.hdl:2268/80861.PMID12711221.
- Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000)."Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway".Genes & Development.14(1): 45–54.doi:10.1101/gad.14.1.45.PMC316335.PMID10640275.
- Lemercier C, Verdel A, Galloo B, Curtet S, Brocard MP, Khochbin S (May 2000)."mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity".The Journal of Biological Chemistry.275(20): 15594–9.doi:10.1074/jbc.M908437199.PMID10748098.
- Grozinger CM, Schreiber SL (July 2000)."Regulation of histone deacetylase 4 and 5 and transcriptional activity by 14-3-3-dependent cellular localization".Proceedings of the National Academy of Sciences of the United States of America.97(14): 7835–40.Bibcode:2000PNAS...97.7835G.doi:10.1073/pnas.140199597.PMC16631.PMID10869435.
- Huynh KD, Fischle W, Verdin E, Bardwell VJ (July 2000)."BCoR, a novel corepressor involved in BCL-6 repression".Genes & Development.14(14): 1810–23.doi:10.1101/gad.14.14.1810.PMC316791.PMID10898795.
- Mahlknecht U,Schnittger S, Ottmann OG, Schoch C, Mosebach M, Hiddemann W, Hoelzer D (October 2000). "Chromosomal organization and localization of the human histone deacetylase 5 gene (HDAC5)".Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression.1493(3): 342–8.doi:10.1016/S0167-4781(00)00191-3.PMID11018260.
- Zhang CL, McKinsey TA, Lu JR, Olson EN (January 2001)."Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor".The Journal of Biological Chemistry.276(1): 35–9.doi:10.1074/jbc.M007364200.PMID11022042.
- McKinsey TA, Zhang CL, Lu J, Olson EN (November 2000)."Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation".Nature.408(6808): 106–11.Bibcode:2000Natur.408..106M.doi:10.1038/35040593.PMC4459600.PMID11081517.
- McKinsey TA, Zhang CL, Olson EN (December 2000)."Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5".Proceedings of the National Academy of Sciences of the United States of America.97(26): 14400–5.Bibcode:2000PNAS...9714400M.doi:10.1073/pnas.260501497.PMC18930.PMID11114197.
- Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001)."Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo".The Journal of Biological Chemistry.276(38): 35826–35.doi:10.1074/jbc.M104935200.PMID11466315.
- McKinsey TA, Zhang CL, Olson EN (September 2001)."Identification of a signal-responsive nuclear export sequence in class II histone deacetylases".Molecular and Cellular Biology.21(18): 6312–21.doi:10.1128/MCB.21.18.6312-6321.2001.PMC87361.PMID11509672.
- Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. (October 2001). "Histone deacetylase 3 associates with and represses the transcription factor GATA-2".Blood.98(7): 2116–23.doi:10.1182/blood.V98.7.2116.PMID11567998.
- Potter GB, Beaudoin GM, DeRenzo CL, Zarach JM, Chen SH, Thompson CC (October 2001)."The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor".Genes & Development.15(20): 2687–701.doi:10.1101/gad.916701.PMC312820.PMID11641275.
- Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR".Molecular Cell.9(1): 45–57.doi:10.1016/S1097-2765(01)00429-4.hdl:11858/00-001M-0000-002C-9FF9-9.PMID11804585.
- Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S (June 2002)."Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor".The Journal of Biological Chemistry.277(24): 22045–52.doi:10.1074/jbc.M201736200.PMID11929873.
- Huang Y, Tan M, Gosink M, Wang KK, Sun Y (May 2002). "Histone deacetylase 5 is not a p53 target gene, but its overexpression inhibits tumor cell growth and induces apoptosis".Cancer Research.62(10): 2913–22.PMID12019172.
External links
[edit]- HDAC5+protein,+humanat the U.S. National Library of MedicineMedical Subject Headings(MeSH)
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.
