IFNA5

IFNA5
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 3OQ3
Identifiers
Aliases	IFNA5,IFN-alpha-5, IFN-alphaG, INA5, INFA5, leIF G, interferon alpha 5
External IDs	OMIM:147565;MGI:2667155;HomoloGene:117697;GeneCards:IFNA5;OMA:IFNA5 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 21,304,326bp End 21,305,313bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 42.02 cM Start 88,561,878bp End 88,562,696bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in mucosa of ileum Achilles tendon sural nerve stromal cell of endometrium right coronary artery right lung gastric mucosa right adrenal cortex popliteal artery tibial arteries Top expressed in embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytokine activity type I interferon receptor binding cytokine receptor binding Cellular component extracellular region extracellular space Biological process natural killer cell activation involved in immune response B cell differentiation defense response B cell proliferation blood coagulation positive regulation of peptidyl-serine phosphorylation of STAT protein humoral immune response adaptive immune response defense response to virus type I interferon signaling pathway response to exogenous dsRNA T cell activation involved in immune response innate immune response cytokine-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 3442 230396 Ensembl ENSG00000147873 ENSMUSG00000063376 UniProt P01569 Q80SU4 RefSeq (mRNA) NM_002169 NM_177347 RefSeq (protein) NP_002160 NP_796321 Location (UCSC) Chr 9: 21.3 – 21.31 Mb Chr 4: 88.56 – 88.56 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Interferon alpha-5is aproteinthat in humans is encoded by theIFNA5gene.

Further reading

• Henco K, Brosius J, Fujisawa A, et al. (1985). "Structural relationship of human interferon alpha genes and pseudogenes".J. Mol. Biol.185(2): 227–60.doi:10.1016/0022-2836(85)90401-2.PMID4057246.
• Goeddel DV, Leung DW, Dull TJ, et al. (1981). "The structure of eight distinct cloned human leukocyte interferon cDNAs".Nature.290(5801): 20–6.Bibcode:1981Natur.290...20G.doi:10.1038/290020a0.PMID6163083.S2CID1900300.
• Tiefenbrun N, Melamed D, Levy N, et al. (1996)."Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest".Mol. Cell. Biol.16(7): 3934–44.doi:10.1128/MCB.16.7.3934.PMC231390.PMID8668211.
• Chuntharapai A, Gibbs V, Lu J, et al. (1999). "Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2".J. Immunol.163(2): 766–73.doi:10.4049/jimmunol.163.2.766.PMID10395669.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004)."DNA sequence and analysis of human chromosome 9".Nature.429(6990): 369–74.Bibcode:2004Natur.429..369H.doi:10.1038/nature02465.PMC2734081.PMID15164053.
• Zhang Z, Henzel WJ (2005)."Signal peptide prediction based on analysis of experimentally verified cleavage sites".Protein Sci.13(10): 2819–24.doi:10.1110/ps.04682504.PMC2286551.PMID15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.