From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Interferon-alpha/beta receptor alpha chain is aprotein that in humans is encoded by theIFNAR1 gene .[5] [6]
Function [ edit ] The protein encoded by this gene is atype I membrane protein that forms one of the two chains of a receptor fortype I interferons ,including interferon-alpha, -beta, and -lambda. Binding and activation of the receptor stimulatesJanus protein kinases ,which in turn phosphorylate several proteins, includingSTAT1 andSTAT2 .The encoded protein also functions as an antiviral factor.[6]
Interactions [ edit ] IFNAR1 has been shown tointeract with:
References [ edit ]
^a b c GRCh38: Ensembl release 89: ENSG00000142166 –Ensembl ,May 2017^a b c GRCm38: Ensembl release 89: ENSMUSG00000022967 –Ensembl ,May 2017^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .^ Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning".Cell .77 (3): 391–400.doi :10.1016/0092-8674(94)90154-6 .PMID 8181059 .S2CID 140206806 . ^a b "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1" .^ Abramovich C, Yakobson B, Chebath J, Revel M (Jan 1997)."A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" .EMBO J .16 (2): 260–6.doi :10.1093/emboj/16.2.260 .PMC 1169633 PMID 9029147 . ^ Li X, Leung S, Kerr IM, Stark GR (Apr 1997)."Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling" .Mol. Cell. Biol .17 (4): 2048–56.doi :10.1128/mcb.17.4.2048 .PMC 232052 PMID 9121453 . ^ Uddin S, Chamdin A, Platanias LC (Oct 1995)."Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" .J. Biol. Chem .270 (42): 24627–30.doi :10.1074/jbc.270.42.24627 PMID 7559568 . ^ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996)."Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" .EMBO J .15 (5): 1064–74.doi :10.1002/j.1460-2075.1996.tb00444.x .PMC 450004 PMID 8605876 . ^ Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998)."Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" .J. Biol. Chem .273 (38): 24723–9.doi :10.1074/jbc.273.38.24723 PMID 9733772 . ^ Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY (Jul 2008)."Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif" .J. Biol. Chem .283 (27): 18566–72.doi :10.1074/jbc.M800991200 PMC 2441555 PMID 18474601 .
Further reading [ edit ]
Bürglin TR, Barnes TM (1992)."Introns in sequence tags" .Nature .357 (6377): 367–8.Bibcode :1992Natur.357..367B .doi :10.1038/357367a0 PMID 1350660 .S2CID 2693051 . Qiujing Yu; Yuliya V Katlinskaya; et al. (2015)."DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function" .Cell Reports .11 (5): 785–797.doi :10.1016/j.celrep.2015.03.069 .PMC 4426031 PMID 25921537 . Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G (1992)."The structure of the human interferon alpha/beta receptor gene" .J. Biol. Chem .267 (4): 2802–9.doi :10.1016/S0021-9258(18)45950-9 PMID 1370833 . Flores I, Mariano TM, Pestka S (1991)."Human interferon omega (omega) binds to the alpha/beta receptor" .J. Biol. Chem .266 (30): 19875–7.doi :10.1016/S0021-9258(18)54862-6 PMID 1834641 . Lutfalla G, Roeckel N, Mogensen KE, Mattei MG, Uzé G (1990). "Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization".J. Interferon Res .10 (5): 515–7.doi :10.1089/jir.1990.10.515 .PMID 2148760 . Uzé G, Lutfalla G, Gresser I (1990). "Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA".Cell .60 (2): 225–34.doi :10.1016/0092-8674(90)90738-Z .PMID 2153461 .S2CID 54409221 . Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J (1994)."Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase" .Mol. Cell. Biol .14 (12): 8133–42.doi :10.1128/mcb.14.12.8133 .PMC 359352 PMID 7526154 . Uddin S, Chamdin A, Platanias LC (1995)."Interaction of the transcriptional activator Stat-2 with the type I interferon receptor" .J. Biol. Chem .270 (42): 24627–30.doi :10.1074/jbc.270.42.24627 PMID 7559568 . Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR (1995)."Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling" .J. Biol. Chem .270 (37): 21606–11.doi :10.1074/jbc.270.37.21606 PMID 7665574 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene .138 (1–2): 171–4.doi :10.1016/0378-1119(94)90802-8 .PMID 8125298 . Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (1996)."Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein" .EMBO J .15 (5): 1064–74.doi :10.1002/j.1460-2075.1996.tb00444.x .PMC 450004 PMID 8605876 . Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM (1996)."Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor" .J. Biol. Chem .271 (14): 8057–61.doi :10.1074/jbc.271.14.8057 PMID 8626489 . Abramovich C, Yakobson B, Chebath J, Revel M (1997)."A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor" .EMBO J .16 (2): 260–6.doi :10.1093/emboj/16.2.260 .PMC 1169633 PMID 9029147 . Eantuzzi L, Eid P, Malorni W, Rainaldi G, Gauzzi MC, Pellegrini S, Belardelli F, Gessani S (1997). "Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon".Eur. J. Immunol .27 (5): 1075–81.doi :10.1002/eji.1830270506 .PMID 9174595 .S2CID 6569287 . Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F (1997)."Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation" .J. Leukoc. Biol .62 (1): 49–53.doi :10.1002/jlb.62.1.49 PMID 9225992 .S2CID 31546644 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library".Gene .200 (1–2): 149–56.doi :10.1016/S0378-1119(97)00411-3 .PMID 9373149 . Krishnan K, Singh B, Krolewski JJ (1998)."Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor" .J. Biol. Chem .273 (31): 19495–501.doi :10.1074/jbc.273.31.19495 PMID 9677371 . Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (1998)."Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1" .J. Biol. Chem .273 (38): 24723–9.doi :10.1074/jbc.273.38.24723 PMID 9733772 . Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM (1999)."Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase" .J. Biol. Chem .274 (45): 32507–11.doi :10.1074/jbc.274.45.32507 PMID 10542297 .
