IL2RB
Interleukin-2 receptor subunit betais aproteinthat in humans is encoded by theIL2RBgene.[5]Also known asCD122;IL15RB;P70-75.[5]
Function[edit]
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bindinterleukin 2.The low affinity form is a monomer of the alpha subunit (also calledCD25) and is not involved in signal transduction. The intermediate affinity form consists of a gamma/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved inreceptor-mediated endocytosisand transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein.[5]
This protein also forms one of the three subunits of theIL-15 receptor.
Activation of the receptor increases proliferation of CD8+ effectorT cells.[6]
Interactions[edit]
IL2RB has been shown tointeractwith:
See also[edit]
References[edit]
- ^abcGRCh38: Ensembl release 89: ENSG00000100385–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000068227–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^abc"Entrez Gene: IL2RB interleukin 2 receptor, beta".
- ^Boyman O, Sprent J (February 17, 2012). "The role of interleukin-2 during homeostasis and activation of the immune system".Nat Rev Immunol.12(3): 180–190.doi:10.1038/nri3156.PMID22343569.S2CID22680847.
- ^Aman MJ, Migone TS, Sasaki A, Ascherman DP, Zhu Mh, Soldaini E, Imada K, Miyajima A, Yoshimura A, Leonard WJ (October 1999)."CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling".J. Biol. Chem.274(42): 30266–72.doi:10.1074/jbc.274.42.30266.PMID10514520.
- ^Yamashita Y, Kojima K, Tsukahara T, Agawa H, Yamada K, Amano Y, Kurotori N, Tanaka N, Sugamura K, Takeshita T (May 2008)."Ubiquitin-independent binding of Hrs mediates endosomal sorting of the interleukin-2 receptor beta-chain".J. Cell Sci.121(Pt 10): 1727–38.doi:10.1242/jcs.024455.PMID18445679.
- ^Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits".Science.266(5187): 1045–7.Bibcode:1994Sci...266.1045M.doi:10.1126/science.7973659.PMID7973659.
- ^Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994)."Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID".Science.266(5187): 1042–5.Bibcode:1994Sci...266.1042R.doi:10.1126/science.7973658.PMID7973658.
- ^Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002)."Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors".J. Immunol.169(3): 1302–8.doi:10.4049/jimmunol.169.3.1302.PMID12133952.
- ^Zhu MH, Berry JA, Russell SM, Leonard WJ (April 1998)."Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta".J. Biol. Chem.273(17): 10719–25.doi:10.1074/jbc.273.17.10719.PMID9553136.
- ^Migone TS, Rodig S, Cacalano NA, Berg M, Schreiber RD, Leonard WJ (November 1998)."Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation".Mol. Cell. Biol.18(11): 6416–22.doi:10.1128/mcb.18.11.6416.PMC109227.PMID9774657.
- ^Delespine-Carmagnat M, Bouvier G, Bertoglio J (January 2000). "Association of STAT1, STAT3 and STAT5 proteins with the IL-2 receptor involves different subdomains of the IL-2 receptor beta chain".Eur. J. Immunol.30(1): 59–68.doi:10.1002/1521-4141(200001)30:1<59::AID-IMMU59>3.0.CO;2-1.PMID10602027.S2CID40742391.
- ^Ravichandran KS, Burakoff SJ (January 1994)."The adapter protein Shc interacts with the interleukin-2 (IL-2) receptor upon IL-2 stimulation".J. Biol. Chem.269(3): 1599–602.doi:10.1016/S0021-9258(17)42066-7.PMID8294403.
Further reading[edit]
- Ellery JM, Nicholls PJ (2002). "Alternate signalling pathways from the interleukin-2 receptor".Cytokine Growth Factor Rev.13(1): 27–40.doi:10.1016/S1359-6101(01)00023-5.PMID11750878.
- Purvis SF, Georges DL, Williams TM, Lederman MM (1992). "Suppression of interleukin-2 and interleukin-2 receptor expression in Jurkat cells stably expressing the human immunodeficiency virus Tat protein".Cell. Immunol.144(1): 32–42.doi:10.1016/0008-8749(92)90223-C.PMID1394441.
- Torigoe T, Saragovi HU, Reed JC (1992)."Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line".Proc. Natl. Acad. Sci. U.S.A.89(7): 2674–8.Bibcode:1992PNAS...89.2674T.doi:10.1073/pnas.89.7.2674.PMC48724.PMID1557373.
- Maslinski W, Remillard B, Tsudo M, Strom TB (1992)."Interleukin-2 (IL-2) induces tyrosine kinase-dependent translocation of active raf-1 from the IL-2 receptor into the cytosol".J. Biol. Chem.267(22): 15281–4.doi:10.1016/S0021-9258(19)49530-6.PMID1639773.
- Miyazaki T, Maruyama M, Yamada G, Hatakeyama M, Taniguchi T (1991)."The integrity of the conserved 'WS motif' common to IL-2 and other cytokine receptors is essential for ligand binding and signal transduction".EMBO J.10(11): 3191–7.doi:10.1002/j.1460-2075.1991.tb04881.x.PMC453042.PMID1915291.
- Shibuya H, Yoneyama M, Nakamura Y, Harada H, Hatakeyama M, Minamoto S, Kono T, Doi T, White R, Taniguchi T (1990)."The human interleukin-2 receptor beta-chain gene: genomic organization, promoter analysis and chromosomal assignment".Nucleic Acids Res.18(13): 3697–703.doi:10.1093/nar/18.13.3697.PMC331067.PMID1973832.
- Hatakeyama M, Kono T, Kobayashi N, Kawahara A, Levin SD, Perlmutter RM, Taniguchi T (1991). "Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association".Science.252(5012): 1523–8.Bibcode:1991Sci...252.1523H.doi:10.1126/science.2047859.PMID2047859.S2CID41503548.
- Mills GB, May C, McGill M, Fung M, Baker M, Sutherland R, Greene WC (1990)."Interleukin 2-induced tyrosine phosphorylation. Interleukin 2 receptor beta is tyrosine phosphorylated".J. Biol. Chem.265(6): 3561–7.doi:10.1016/S0021-9258(19)39806-0.PMID2303462.
- Oyaizu N, Chirmule N, Kalyanaraman VS, Hall WW, Pahwa R, Shuster M, Pahwa S (1990)."Human immunodeficiency virus type 1 envelope glycoprotein gp120 produces immune defects in CD4+ T lymphocytes by inhibiting interleukin 2 mRNA".Proc. Natl. Acad. Sci. U.S.A.87(6): 2379–83.Bibcode:1990PNAS...87.2379O.doi:10.1073/pnas.87.6.2379.PMC53690.PMID2315327.
- Gnarra JR, Otani H, Wang MG, McBride OW, Sharon M, Leonard WJ (1990)."Human interleukin 2 receptor beta-chain gene: chromosomal localization and identification of 5' regulatory sequences".Proc. Natl. Acad. Sci. U.S.A.87(9): 3440–4.Bibcode:1990PNAS...87.3440G.doi:10.1073/pnas.87.9.3440.PMC53916.PMID2333293.
- Tsudo M, Kitamura F, Miyasaka M (1989)."Characterization of the interleukin 2 receptor beta chain using three distinct monoclonal antibodies".Proc. Natl. Acad. Sci. U.S.A.86(6): 1982–6.Bibcode:1989PNAS...86.1982T.doi:10.1073/pnas.86.6.1982.PMC286829.PMID2467293.
- Hatakeyama M, Tsudo M, Minamoto S, Kono T, Doi T, Miyata T, Miyasaka M, Taniguchi T (1989). "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's".Science.244(4904): 551–6.Bibcode:1989Sci...244..551H.doi:10.1126/science.2785715.PMID2785715.
- Kornfeld H, Cruikshank WW, Pyle SW, Berman JS, Center DM (1988)."Lymphocyte activation by HIV-1 envelope glycoprotein".Nature.335(6189): 445–8.Bibcode:1988Natur.335..445K.doi:10.1038/335445a0.PMID2843775.S2CID4326650.
- Leonard WJ, Donlon TA, Lebo RV, Greene WC (1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10".Science.228(4707): 1547–9.Bibcode:1985Sci...228.1547L.doi:10.1126/science.3925551.PMID3925551.
- Bamborough P, Hedgecock CJ, Richards WG (1994)."The interleukin-2 and interleukin-4 receptors studied by molecular modelling".Structure.2(9): 839–51.doi:10.1016/S0969-2126(94)00085-9.PMID7529123.
- Minami Y, Nakagawa Y, Kawahara A, Miyazaki T, Sada K, Yamamura H, Taniguchi T (1995)."Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway".Immunity.2(1): 89–100.doi:10.1016/1074-7613(95)90081-0.PMID7600304.
- Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM (1995)."Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor".EMBO J.14(15): 3654–63.doi:10.1002/j.1460-2075.1995.tb00035.x.PMC394440.PMID7641685.
- Kirken RA, Rui H, Evans GA, Farrar WL (1993)."Characterization of an interleukin-2 (IL-2)-induced tyrosine phosphorylated 116-kDa protein associated with the IL-2 receptor beta-subunit".J. Biol. Chem.268(30): 22765–70.doi:10.1016/S0021-9258(18)41592-X.PMID7693677.
- Puri RK, Leland P, Aggarwal BB (1995). "Constitutive expression of human immunodeficiency virus type 1 tat gene inhibits interleukin 2 and interleukin 2 receptor expression in a human CD4+ T lymphoid (H9) cell line".AIDS Res. Hum. Retroviruses.11(1): 31–40.doi:10.1089/aid.1995.11.31.PMID7734194.
- Miyazaki T, Liu ZJ, Kawahara A, Minami Y, Yamada K, Tsujimoto Y, Barsoumian EL, Permutter RM, Taniguchi T (1995)."Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation".Cell.81(2): 223–31.doi:10.1016/0092-8674(95)90332-1.PMID7736574.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.
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