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Icrucumab

From Wikipedia, the free encyclopedia
Icrucumab
Monoclonal antibody
TypeWhole antibody
SourceHuman
TargetVEGFR-1
Clinical data
Other namesIMC-18F1
ATC code
  • none
Identifiers
CAS Number
ChemSpider
  • none
UNII
KEGG
Chemical and physical data
FormulaC6514H10024N1756O2032S42
Molar mass146796.63g·mol−1
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Icrucumab(IMC-18F1) is a human monoclonal antibody designed for the treatment of solid tumors.[1][2]

Icrucumab was developed by ImClone Systems Inc. It is undergoing Phase I trials.[3]

References

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  1. ^"Statement On A Nonproprietary Name Adopted By The USAN Council: Icrucumab"(PDF).American Medical Association.
  2. ^LoRusso PM, Krishnamurthi S, Youssoufian H, Hall N, Fox F, Dontabhaktuni A, Grebennik D, Remick S (April 2014). "Icrucumab, a fully human monoclonal antibody against the vascular endothelial growth factor receptor-1, in the treatment of patients with advanced solid malignancies: a Phase 1 study".Invest New Drugs.32(2): 303–11.doi:10.1007/s10637-013-9998-8.PMID23903897.S2CID34756277.
  3. ^Clinical trial numberNCT00782002for "Safety Study of IMC-18F1, to Treat Advanced Solid Tumors in Subjects That no Longer Respond to Standard Therapy" atClinicalTrials.gov