Interleukin-27 receptor
Appearance
interleukin 27 receptor, alpha | |||||||
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Identifiers | |||||||
Symbol | IL27RA | ||||||
Alt. symbols | WSX-1, TCCR, CRL1, WSX1, zcytor1, IL-27R | ||||||
NCBI gene | 9466 | ||||||
HGNC | 17290 | ||||||
OMIM | 605350 | ||||||
RefSeq | NM_004843 | ||||||
UniProt | Q6UWB1 | ||||||
Other data | |||||||
Locus | Chr. 19p13.11 | ||||||
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interleukin 6 signal transducer (gp130, oncostatin M receptor) | |||||||
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Identifiers | |||||||
Symbol | IL6ST | ||||||
Alt. symbols | GP130, CD130 | ||||||
NCBI gene | 3572 | ||||||
HGNC | 6021 | ||||||
OMIM | 600694 | ||||||
RefSeq | NM_002184 | ||||||
UniProt | P40189 | ||||||
Other data | |||||||
Locus | Chr. 5q11 | ||||||
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Theinterleukin-27 receptoris atype I cytokine receptorforinterleukin-27.It is aheterodimercomposed of theinterleukin 27 receptor, alpha subunit[1][2]andglycoprotein 130.[3]
IL27RA essential for transcriptional activation ofSTAT1and for augmenting the induction ofT-betexpression during initiation ofTh1 celldifferentiation.[4]
References
[edit]- ^Sprecher CA, Grant FJ, Baumgartner JW, Presnell SR, Schrader SK, Yamagiwa T, Whitmore TE, O'Hara PJ, Foster DF (1998). "Cloning and characterization of a novel class I cytokine receptor".Biochem. Biophys. Res. Commun.246(1): 82–90.doi:10.1006/bbrc.1998.8576.PMID9600072.
- ^Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, Grewal IS, de Sauvage FJ (2000). "Development of Th1-type immune responses requires the type I cytokine receptor TCCR".Nature.407(6806): 916–20.Bibcode:2000Natur.407..916C.doi:10.1038/35038103.PMID11057672.S2CID205009928.
- ^Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, Phillips JH, McClanahan TK, de Waal Malefyt R, Kastelein RA (February 2004)."WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27".Journal of Immunology.172(4): 2225–31.doi:10.4049/jimmunol.172.4.2225.PMID14764690.
- ^Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, Yoshimura A, Yoshida H (May 2003)."Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment".J. Immunol.170(10): 4886–90.doi:10.4049/jimmunol.170.10.4886.PMID12734330.
External links
[edit]- Receptors,+Interleukin-27at the U.S. National Library of MedicineMedical Subject Headings(MeSH)