IL1F10

"IL-38" redirects here. For the aircraft, seeIlyushin Il-38.For the road, seeIllinois Route 38.

IL1F10
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 5BOW
Identifiers
Aliases	IL1F10,FIL1-theta, IL-1HY2, IL-38, IL1-theta, IL1HY2, FKSG75, interleukin 1 family member 10 (theta), interleukin 1 family member 10
External IDs	OMIM:615296;MGI:2652548;HomoloGene:17690;GeneCards:IL1F10;OMA:IL1F10 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) Band 2q14.1 Start 113,067,970bp End 113,075,843bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2 A3|2 16.32 cM Start 24,181,208bp End 24,183,832bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in skin of limb skin of leg skin of abdomen skin of thigh human penis amniotic fluid gonad pharynx tonsil placenta Top expressed in lip skin of abdomen skin of external ear skin of back hair follicle cervix thymus More reference expression data BioGPS n/a
Gene ontology Molecular function cytokine activity interleukin-1 receptor binding Cellular component extracellular space extracellular region Biological process inflammatory response immune response regulation of signaling receptor activity cytokine-mediated signaling pathway cellular response to cytokine stimulus neutrophil chemotaxis positive regulation of interleukin-6 production positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of JNK cascade cellular response to lipopolysaccharide Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 84639 215274 Ensembl ENSG00000136697 ENSMUSG00000046845 UniProt Q8WWZ1 Q8R459 RefSeq (mRNA) NM_173161 NM_032556 NM_153077 RefSeq (protein) NP_115945 NP_775184 NP_694717 Location (UCSC) Chr 2: 113.07 – 113.08 Mb Chr 2: 24.18 – 24.18 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Interleukin-1 family member 10is aproteinthat in humans is encoded by theIL1F10gene.

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. This cytokine is thought to participate in a network of interleukin 1 family members to regulate adapted and innate immune responses. Two alternatively spliced transcript variants encoding the same protein have been reported.

Further reading

• Nicklin MJ, Weith A, Duff GW (1994). "A physical map of the region encompassing the human interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist genes".Genomics.19(2): 382–4.doi:10.1006/geno.1994.1076.PMID8188271.
• Nothwang HG, Strahm B, Denich D, et al. (1997). "Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC/PAC contig and a partial transcriptional map in the region of chromosome 2q13".Genomics.41(3): 370–8.doi:10.1006/geno.1997.4654.PMID9169134.
• Mulero JJ, Pace AM, Nelken ST, et al. (1999). "IL1HY1: A novel interleukin-1 receptor antagonist gene".Biochem. Biophys. Res. Commun.263(3): 702–6.doi:10.1006/bbrc.1999.1440.PMID10512743.
• Smith DE, Renshaw BR, Ketchem RR, et al. (2000)."Four new members expand the interleukin-1 superfamily".J. Biol. Chem.275(2): 1169–75.doi:10.1074/jbc.275.2.1169.PMID10625660.
• Kumar S, McDonnell PC, Lehr R, et al. (2000)."Identification and initial characterization of four novel members of the interleukin-1 family".J. Biol. Chem.275(14): 10308–14.doi:10.1074/jbc.275.14.10308.PMID10744718.
• Busfield SJ, Comrack CA, Yu G, et al. (2000). "Identification and gene organization of three novel members of the IL-1 family on human chromosome 2".Genomics.66(2): 213–6.doi:10.1006/geno.2000.6184.PMID10860666.
• Barton JL, Herbst R, Bosisio D, et al. (2001)."A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities".Eur. J. Immunol.30(11): 3299–308.doi:10.1002/1521-4141(200011)30:11<3299::AID-IMMU3299>3.0.CO;2-S.PMID11093146.
• Pan G, Risser P, Mao W, et al. (2001). "IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp".Cytokine.13(1): 1–7.doi:10.1006/cyto.2000.0799.PMID11145836.
• Lin H, Ho AS, Haley-Vicente D, et al. (2001)."Cloning and characterization of IL-1HY2, a novel interleukin-1 family member".J. Biol. Chem.276(23): 20597–602.doi:10.1074/jbc.M010095200.PMID11278614.
• Debets R, Timans JC, Homey B, et al. (2001). "Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2".Journal of Immunology.167(3): 1440–6.doi:10.4049/jimmunol.167.3.1440.PMID11466363.S2CID85986577.
• Sims JE, Nicklin MJ, Bazan JF, et al. (2001). "A new nomenclature for IL-1-family genes".Trends Immunol.22(10): 536–7.doi:10.1016/S1471-4906(01)02040-3.PMID11574262.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003)."The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment".Genome Res.13(10): 2265–70.doi:10.1101/gr.1293003.PMC403697.PMID12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005)."Generation and annotation of the DNA sequences of human chromosomes 2 and 4".Nature.434(7034): 724–31.Bibcode:2005Natur.434..724H.doi:10.1038/nature03466.PMID15815621.