Intimal hyperplasia
Intimal hyperplasiais the thickening of thetunica intimaof a blood vessel as a complication of a reconstruction procedure orendarterectomy.[1]Intimal hyperplasia is the universal response of a vessel to injury. It is arestenosisand this is an important reason of latebypass graftfailure, particularly in vein and synthetic vascular grafts.[2]
Cause
[edit]Intimal hyperplasia is due to a dysfunction ofendothelial cellswhich results in a reprogramming of thevascular smooth muscle cells(VSMCs). As a result, VSMCs proliferate and change theirphenotype.[3]
Possible treatment
[edit]A possible treatment to avoid this could behydrogen sulfide.Hydrogen sulfide (H2S) works as a vasculoprotectivegasotransmitterin the human body but is also tested to reduced intimal hyperplasia. There are different kinds ofH2Sdonors: NaHS (the reference in scientific literature despite the fact it is too toxic to use it in human patients) and STS (already used in patient to treatcyanide poisoning).
See also
[edit]References
[edit]- ^Kaban, Leonard B. (1 January 2004)."CHAPTER 20 - Acquired Abnormalities of the Temporomandibular Joint".Pediatric Oral and Maxillofacial Surgery.W.B. Saunders. pp. 340–376.ISBN978-0-7216-9691-1.Retrieved20 October2021.
- ^Haruguchi, Hiroaki; Teraoka, Satoshi (2003)."Intimal hyperplasia and hemodynamic factors in arterial bypass and arteriovenous grafts: a review".Journal of Artificial Organs.6(4): 227–235.doi:10.1007/s10047-003-0232-x.ISSN1434-7229.PMID14691664.S2CID24921182.
- ^Déglise, Sébastien; Bechelli, Clémence; Allagnat, Florent (2022)."Vascular smooth muscle cells in intimal hyperplasia, an update".Frontiers in Physiology.13:1081881.doi:10.3389/fphys.2022.1081881.ISSN1664-042X.PMC9845604.PMID36685215.
External links
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