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Julius Wagner-Jauregg

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Julius Wagner-Jauregg
Julius Wagner-Jauregg with his signature
Born
Julius Wagner

(1857-03-07)7 March 1857
Wels,Austrian Empire
Died27 September 1940(1940-09-27)(aged 83)
Vienna,Nazi Germany
NationalityAustrian
Other namesJulius Wagner
Alma materUniversity of Vienna
Known forMalariotherapy
Spouse(s)Balbine Frumkin (divorced 1903)
Anna Koch (married 1899)
ChildrenJulia and Theodor
AwardsNobel Prize in Physiology or Medicine(1927)
Cameron Prize for Therapeutics of the University of Edinburgh(1935)
Scientific career
FieldsPathology
Psychiatry
InstitutionsUniversity of Vienna
University of Graz
State Lunatic Asylum at Steinhof
ThesisL'origine et la fonction du coeur accélére (Origin and function of the accelerated heart)(1880)
Doctoral advisorSalomon Stricker
Signature

Julius Wagner-Jauregg(German:[ˈjuːli̯ʊsˈvaːɡnɐˈjaʊʁɛk];7 March 1857 – 27 September 1940) was an Austrianphysician,who won theNobel Prize in Physiology or Medicinein 1927, and is the first psychiatrist to have done so. His Nobel award was "for his discovery of the therapeutic value ofmalaria inoculationin the treatment ofdementia paralytica".[1]

Early life[edit]

Wagner-Jauregg family arms, granted in 1883.

Julius Wagner-Jauregg was bornJulius Wagneron 7 March 1857 inWels,Upper Austria,the son of Adolph Johann Wagner and Ludovika Jauernigg Ranzoni.[2]His family name was changed to "Wagner von Jauregg" when his father was given the title of "Rittervon Jauregg "(a hereditary title of nobility) in 1883 by the Austro-Hungarian Empire. Hence he retained the name Julius Wagner Ritter von Jauregg until 1918 when the empire was dissolved, and nobility was abolished. The family name was then contracted to" Wagner-Jauregg ".[3]He attended theSchottengymnasiumin Vienna before going on to studyMedicineat theUniversity of Viennafrom 1874 to 1880, where he also studied withSalomon Strickerin the Institute of General and Experimental Pathology. He obtained his doctorate in 1880 with the thesis "L'origine et la fonction du cœur accéléré."[2]He left the institute in 1882.

After leaving the clinic, he conducted laboratory experiments with animals, which was practiced very little at this time.[2]From 1883 to 1887 he worked withMaximilian Leidesdorfin the Psychiatric Clinic, although his original training was not in the pathology of the nervous system. In 1889 he succeeded the famousRichard von Krafft-Ebingat the Neuro-Psychiatric Clinic of theUniversity of Graz,and started his research onGoitre,cretinismandiodine.In 1893 he became Extraordinary Professor of Psychiatry and Nervous Diseases, and Director of the Clinic for Psychiatry and Nervous Diseases inVienna,as successor toTheodor Meynert.A student and assistant of Wagner-Jauregg during this time wasConstantin von Economo.

Ten years later, in 1902, Wagner-Jauregg moved to the psychiatric clinic at the General Hospital and in 1911 he returned to his former post.

Criminal inquest[edit]

Wagner-Jauregg was angered by what he considered as themalingeringof soldiers who claimed to be too mentally upset to return to the battlefield. He applied extremeelectric shock therapyto these soldiers, which caused large numbers of deaths. After the end of the war, the German government opened an inquest into these activities, with the goal of prosecuting him criminally.Sigmund Freudintervened to save Wagner-Jauregg's career.[4]

Nobel prize[edit]

Wagner-Jauregg (center right in black jacket) watching a transfusion from a malaria patient (rear of the group) to a neurosyphilis victim (center) in 1934

The main work pursued by Wagner-Jauregg throughout his life was related to the treatment ofmental diseaseby inducing afever,an approach known aspyrotherapy.In 1887 he investigated the effects of febrile diseases onpsychoses,making use of the streptococci that causeerysipelasandtuberculin(the latter discovered in 1890 byRobert Koch). Since these methods of treatment did not work very well, he tried in 1917 the inoculation ofmalariaparasites, which proved to be very successful in the case of dementia paralytica (also calledgeneral paresis of the insane), caused byneurosyphilis,at that time aterminal disease.[5]It had been observed that some who develop high fevers would be cured of syphilis. Thus, from 1917 to the mid 1940s, malaria induced by the least aggressive parasite,Plasmodium vivax,was used as treatment for tertiary syphilis because it produced prolonged and high fevers (a form of pyrotherapy). This was considered an acceptable risk because the malaria could later be treated with quinine, which was available at that time. This discovery earned him theNobel Prize in Medicinein 1927. His main publication was a book titledVerhütung und Behandlung der progressiven Paralyse durch Impfmalaria(Prevention and treatment of progressive paralysis by malaria inoculation) in the Memorial Volume of the Handbuch der experimentellen Therapie, (1931). The technique was known asmalariotherapy;however, it was dangerous, killing about 15% of patients, so it is no longer in use.[6]

In 1935, he was awarded theCameron Prize for Therapeutics of the University of Edinburgh.

Involuntary sterilizations[edit]

Wagner-Jauregg administered thyroid and ovarian preparations to young psychotic patients who had experienced delayed puberty, which led to the development of their secondary sexual characteristics and diminished psychosis. Other patients were deemedschizophrenicbecause of excessivemasturbation,where Wagner-Jauregg sterilized them, resulting in an "improved" condition.[7]

Retirement[edit]

In 1928, Wagner-Jauregg retired from his post but remained active and in good health until his death on 27 September 1940. In his retirement he published nearly 80 scientific papers.[2]Many schools, roads and hospitals are named after him in Austria.[citation needed]

Nazi ideology and affiliation[edit]

Towards his last days Wagner-Jauregg was influenced byAdolf Hitler's German nationalism, and became ananti-Semite[8]and sympathizer of Nazism.[9]Documentary evidence indicates that he supported theNazi partyshortly after the invasion of Austria in 1938 by Germany.[10][11][12][13]However, adenazificationcommission in Austria found that his application for NSDAP membership had been refused "...on grounds of race", as his first wife Balbine Frumkin was Jewish.[14]

Wagner-Jauregg advocated aracial hygieneideology calledeugenics,[14]influencing students such asAlexander Pilcz,who went on to author a standard handbook on racial psychiatry critical of Jews for being prone to mental illness.[15]

He was also an advocate of forced sterilization of the mentally ill and criminal,[12]having endorsed the concept in 1935 while a member of the Austrian Anthropological Society.[16]

He was President of the Austrian League for Racial Regeneration and Heredity, which advocated sterilization for those of inferior genetics.[17]

See also[edit]

References[edit]

  1. ^"The Nobel Prize in Physiology or Medicine 1927".Nobelprize.org.Nobel Media AB.Retrieved20 March2014.
  2. ^abcd"Physiology or medicine, 1922-1941",Jan Lindsten. World Scientific, 1999. p. 170.ISBN981-02-3410-4,ISBN978-981-02-3410-2.
  3. ^"Julius Wagner-Jauregg Biography (1857-1940)".Advameg, Inc.Retrieved20 March2014.
  4. ^Scull, Andrew T. (2005).Madhouse: a tragic tale of megalomania and modern medicine.New Haven: Yale University Press. p. 87.ISBN978-0-300-10729-6.
  5. ^Raju T (2006)."Hot brains: manipulating body heat to save the brain".Pediatrics.117(2): e320–1.doi:10.1542/peds.2005-1934.PMID16452338.
  6. ^Gretchen Vogel (8 November 2013). "Malaria as a Lifesaving Therapy".Science.342(6159): 686.Bibcode:2013Sci...342..686V.doi:10.1126/science.342.6159.686.PMID24202157.
  7. ^"Endocrine Psychiatry: Solving the Riddle of Melancholia",Edward Shorter, Max Fink. Oxford University Press US, 2010. p. 23.ISBN0-19-973746-0,ISBN978-0-19-973746-8.
  8. ^"Shock therapy: a history of electroconvulsive treatment in mental illness",Edward Shorter, David Healy. Rutgers University Press, 2007. p. 20.ISBN0-8135-4169-7,ISBN978-0-8135-4169-3.
  9. ^"Madhouse: A Tragic Tale of Megalomania and Modern Medicine",Andrew Scull. Yale University Press, 2007. p. 86.ISBN0-300-12670-0,ISBN978-0-300-12670-9.
  10. ^"The Trials of Masculinity: Policing Sexual Boundaries, 1870-1930",Angus McLaren. University of Chicago Press, 1999.ISBN0-226-50068-3,ISBN978-0-226-50068-3.Retrieved March 16, 2010.
  11. ^"A historical dictionary of psychiatry",Edward Shorter. Oxford University Press US, 2005. p. 299.ISBN0-19-517668-5,ISBN978-0-19-517668-1
  12. ^ab"The complete idiot's guide to understanding the brain",Arthur Bard, Mitchell Geoffrey Bard. Alpha Books, 2002. p. 49.ISBN0-02-864310-0,ISBN978-0-02-864310-6.
  13. ^Julius Wagner-Jauregg (1857-1940), Magda Whitrow. Smith-Gordon, 1993. p. 199.ISBN1-85463-012-1,ISBN978-1-85463-012-4.
  14. ^ab"Vienna: a doctor's guide: 15 walking tours through Vienna's medical history",Wolfgang Regal, Michael Nanut. Springer, 2007. p. 75.ISBN3-211-48949-5,ISBN978-3-211-48949-9.
  15. ^"Love+marriage: and other essays on representing difference",Sander L. Gilman. Stanford University Press, 1998. p.105-106.ISBN0-8047-3262-0,ISBN978-0-8047-3262-8.
  16. ^"Interwar Vienna: Culture Between Tradition and Modernity",Deborah Holmes, Lisa Silverman. Camden House, 2009. p. 101.ISBN1-57113-420-4,ISBN978-1-57113-420-2.
  17. ^"Freud's foes: psychoanalysis, science, and resistance",Kurt Jacobsen. Rowman & Littlefield, 2009. p. 105. 0742522636, 9780742522633.

Further reading[edit]

  • Magda Whitrow.Julius Wagner-Jauregg (1857–1940).London: Smith-Gordon, 1993.
  • Neugebauer, Wolfgang / Scholz, Kurt / Schwarz, Peter (Hrsg.),Julius Wagner-Jauregg im Spannungsfeld politischer Ideen und Interessen - eine Bestandsaufnahme. Beiträge des Workshops vom 6./7. November 2006 im Wiener Rathaus(Frankfurt am Main u.a., Peter Lang, 2008) (Wiener Vorlesungen: Forschungen, 3).

External links[edit]

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