KIF20A

KIF20A
Identifiers
Aliases	KIF20A,MKLP2, RAB6KIFL, kinesin family member 20A, RCM6
External IDs	OMIM:605664;MGI:1201682;HomoloGene:38093;GeneCards:KIF20A;OMA:KIF20A - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	138,187,723bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,766,330bp
RNA expressionpattern
	Top expressed in
	ventricular zone; ; gonad; ; oocyte; ; embryo; ; secondary oocyte; ; ganglionic eminence; ; testicle; ; stromal cell of endometrium; ; bone marrow; ; trabecular bone;
	Top expressed in
	genital tubercle; ; spermatocyte; ; primitive streak; ; epiblast; ; abdominal wall; ; tail of embryo; ; maxillary prominence; ; mandibular prominence; ; zygote; ; somite;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; transporter activity; microtubule binding; ATPase activity; protein binding; ATP binding; protein kinase binding;
Cellular component	cytoplasm; Golgi apparatus; kinesin complex; spindle; midbody; microtubule; cytoskeleton; nucleoplasm; cleavage furrow; intercellular bridge; nucleus;
Biological process	mitotic cytokinesis; microtubule-based movement; microtubule bundle formation; protein transport; septum digestion after cytokinesis; vesicle-mediated transport; cytokinesis; regulation of cytokinesis; midbody abscission;
	Sources:Amigo/QuickGO
Orthologs
	10112
	19348
	ENSG00000112984
	ENSMUSG00000003779
	O95235
	P97329
	NM_005733
	NM_001166406; NM_001166407; NM_009004
	NP_005724
	NP_001159878; NP_001159879; NP_033030
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF20Ais aproteinthat in humans is encoded by theKIF20Agene.^[5]^[6]^[7]

Interactions

KIF20A has been shown tointeractwithRAB6A.^[8]^[9]

References

^^a ^b ^cGRCh38: Ensembl release 89: ENSG00000112984–Ensembl,May 2017
^^a ^b ^cGRCm38: Ensembl release 89: ENSMUSG00000003779–Ensembl,May 2017
^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
^Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001)."All kinesin superfamily protein, KIF, genes in mouse and human".Proc Natl Acad Sci U S A.98(13): 7004–11.Bibcode:2001PNAS...98.7004M.doi:10.1073/pnas.111145398.PMC34614.PMID 11416179.
^Lai F, Fernald AA, Zhao N, Le Beau MM (July 2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene".Gene.248(1–2): 117–25.doi:10.1016/S0378-1119(00)00135-9.PMID 10806357.
^"Entrez Gene: KIF20A kinesin family member 20A".
^Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6".Science.279(5350): 580–5.Bibcode:1998Sci...279..580E.doi:10.1126/science.279.5350.580.PMID 9438855.
^Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000)."Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms".Mol. Biol. Cell.11(11): 3819–33.doi:10.1091/mbc.11.11.3819.PMC15039.PMID 11071909.

Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6".Science.279(5350): 580–5.Bibcode:1998Sci...279..580E.doi:10.1126/science.279.5350.580.PMID 9438855.
Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes".Blood.93(10): 3418–31.doi:10.1182/blood.V93.10.3418.410k23_3418_3431.PMID 10233894.
Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus".J. Cell Sci.113(15): 2725–35.doi:10.1242/jcs.113.15.2725.PMID 10893188.
Hill E, Clarke M, Barr FA (2000)."The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis".EMBO J.19(21): 5711–9.doi:10.1093/emboj/19.21.5711.PMC305783.PMID 11060022.
Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (2001)."Alternative Splicing of the Human Rab6A Gene Generates Two Close but Functionally Different Isoforms".Mol. Biol. Cell.11(11): 3819–33.doi:10.1091/mbc.11.11.3819.PMC15039.PMID 11071909.
Hartley JL, Temple GF, Brasch MA (2001)."DNA Cloning Using In Vitro Site-Specific Recombination".Genome Res.10(11): 1788–95.doi:10.1101/gr.143000.PMC310948.PMID 11076863.
Nagura M, Nagao Y, Takita J, Igarashi T, LeGuern E, Hayashi Y (2003). "The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C".Int. J. Mol. Med.11(1): 45–7.doi:10.3892/ijmm.11.1.45.PMID 12469216.
Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003)."Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis".J. Cell Biol.162(5): 863–75.doi:10.1083/jcb.200306009.PMC2172827.PMID 12939256.
Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004)."Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2".J. Cell Biol.166(2): 167–72.doi:10.1083/jcb.200403084.PMC2172317.PMID 15263015.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004)."From ORFeome to Biology: A Functional Genomics Pipeline".Genome Res.14(10B): 2136–44.doi:10.1101/gr.2576704.PMC528930.PMID 15489336.
Taniuchi K, Nakagawa H, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, Nakamura Y (2005)."Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell".Cancer Res.65(1): 105–12.doi:10.1158/0008-5472.105.65.1.PMID 15665285.S2CID 16616574.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006)."The LIFEdb database in 2006".Nucleic Acids Res.34(Database issue): D415–8.doi:10.1093/nar/gkj139.PMC1347501.PMID 16381901.
Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006)."Phosphoproteome analysis of the human mitotic spindle".Proc. Natl. Acad. Sci. U.S.A.103(14): 5391–6.Bibcode:2006PNAS..103.5391N.doi:10.1073/pnas.0507066103.PMC1459365.PMID 16565220.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID 17081983.S2CID 7827573.

External links

KIF20Ahuman gene location in theUCSC Genome Browser.
KIF20Ahuman gene details in theUCSC Genome Browser.

This article on ageneon humanchromosome 5is astub.You can help Wikipedia byexpanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000112984–Ensembl,May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003779–Ensembl,May 2017

[3] "Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11416179-5] Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001)."All kinesin superfamily protein, KIF, genes in mouse and human".Proc Natl Acad Sci U S A.98(13): 7004–11.Bibcode:2001PNAS...98.7004M.doi:10.1073/pnas.111145398.PMC34614.PMID 11416179.

[pmid10806357-6] Lai F, Fernald AA, Zhao N, Le Beau MM (July 2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene".Gene.248(1–2): 117–25.doi:10.1016/S0378-1119(00)00135-9.PMID 10806357.

[entrez-7] "Entrez Gene: KIF20A kinesin family member 20A".

[pmid9438855-8] Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6".Science.279(5350): 580–5.Bibcode:1998Sci...279..580E.doi:10.1126/science.279.5350.580.PMID 9438855.

[pmid11071909-9] Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000)."Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms".Mol. Biol. Cell.11(11): 3819–33.doi:10.1091/mbc.11.11.3819.PMC15039.PMID 11071909.

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Interactions

References

Further reading

External links