Keratin 18

KRT18
Identifiers
Aliases	KRT18,CK-18, CYK18, K18, keratin 18
External IDs	OMIM:148070;MGI:96692;HomoloGene:55448;GeneCards:KRT18;OMA:KRT18 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q13.13 Start 52,948,871bp End 52,952,906bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 F2|15 57.22 cM Start 101,936,615bp End 101,940,462bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in mucosa of sigmoid colon mucosa of ileum mucosa of transverse colon rectum olfactory zone of nasal mucosa body of pancreas parotid gland placenta islet of Langerhans nasal epithelium Top expressed in transitional epithelium of urinary bladder epithelium of stomach lacrimal gland mucous cell of stomach submandibular gland lobe of prostate seminal vesicula crypt of lieberkuhn of small intestine pyloric antrum parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scaffold protein binding structural molecule activity protein binding cadherin binding involved in cell-cell adhesion RNA binding Cellular component cytoplasm centriolar satellite keratin filament microtubule organizing center nucleolus perinuclear region of cytoplasm extracellular exosome intermediate filament cell periphery nucleus cytosol Biological process Golgi to plasma membrane CFTR protein transport extrinsic apoptotic signaling pathway anatomical structure morphogenesis negative regulation of apoptotic process tumor necrosis factor-mediated signaling pathway intermediate filament cytoskeleton organization cell cycle viral process hepatocyte apoptotic process cell-cell adhesion keratinization cornification Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 3875 16668 Ensembl ENSG00000111057 ENSMUSG00000023043 UniProt P05783 P05784 RefSeq (mRNA) NM_199187 NM_000224 NM_010664 RefSeq (protein) NP_000215 NP_954657 NP_034794 Location (UCSC) Chr 12: 52.95 – 52.95 Mb Chr 15: 101.94 – 101.94 Mb PubMedsearch
Wikidata
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Keratin 18is atype I cytokeratin.It is, together with its filament partnerkeratin 8,perhaps the most commonly found products of theintermediate filamentgene family. They are expressed in single layerepithelial tissuesof the body. Mutations in this gene have been linked tocryptogeniccirrhosis.Two transcript variants encoding the same protein have been found for this gene.

Keratin 18 is often used together withkeratin 8andkeratin 19to differentiate cells of epithelial origin from hematopoietic cells in tests that enumeratecirculating tumor cellsin blood.

Interactions

Keratin 18 has been shown tointeractwithCollagen, type XVII, alpha 1,DNAJB6,PininandTRADD.

Further reading

• Omary MB, Baxter GT, Chou CF, et al. (1992)."PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18".J. Cell Biol.117(3): 583–93.doi:10.1083/jcb.117.3.583.PMC2289443.PMID1374067.
• Waseem A, Gough AC, Spurr NK, Lane EB (1990). "Localization of the gene for human simple epithelial keratin 18 to chromosome 12 using polymerase chain reaction".Genomics.7(2): 188–94.doi:10.1016/0888-7543(90)90540-B.PMID1693358.
• Heath P, Elvin P, Jenner D, et al. (1990). "Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation".Hum. Genet.85(6): 669–70.doi:10.1007/BF00193596.PMID1699878.S2CID19296094.
• Waseem A, Alexander CM, Steel JB, Lane EB (1991). "Embryonic simple epithelial keratins 8 and 18: chromosomal location emphasizes difference from other keratin pairs".New Biol.2(5): 464–78.PMID1705144.
• Romano V, Hatzfeld M, Magin TM, et al. (1986). "Cytokeratin expression in simple epithelia. I. Identification of mRNA coding for human cytokeratin no. 18 by a cDNA clone".Differentiation.30(3): 244–53.doi:10.1111/j.1432-0436.1986.tb00787.x.PMID2422083.
• Oshima RG, Millán JL, Ceceña G (1987). "Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation".Differentiation.33(1): 61–8.doi:10.1111/j.1432-0436.1987.tb01542.x.PMID2434380.
• Leube RE, Bosch FX, Romano V, et al. (1987). "Cytokeratin expression in simple epithelia. III. Detection of mRNAs encoding human cytokeratins nos. 8 and 18 in normal and tumor cells by hybridization with cDNA sequences in vitro and in situ".Differentiation.33(1): 69–85.doi:10.1111/j.1432-0436.1986.tb00412.x.PMID2434381.
• Kulesh DA, Oshima RG (1988)."Cloning of the human keratin 18 gene and its expression in nonepithelial mouse cells".Mol. Cell. Biol.8(4): 1540–50.doi:10.1128/MCB.8.4.1540.PMC363314.PMID2454392.
• Sémat A, Vasseur M, Maillet L, et al. (1988). "Sequence analysis of murine cytokeratin endo A (no. 8) cDNA. Evidence for mRNA species initiated upstream of the normal 5' end in PCC4 cells".Differentiation.37(1): 40–6.doi:10.1111/j.1432-0436.1988.tb00794.x.PMID2454862.
• Kulesh DA, Oshima RG (1989). "Complete structure of the gene for human keratin 18".Genomics.4(3): 339–47.doi:10.1016/0888-7543(89)90340-6.PMID2469635.
• Ku NO, Omary MB (1994)."Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization".J. Cell Biol.127(1): 161–71.doi:10.1083/jcb.127.1.161.PMC2120194.PMID7523419.
• Liao J, Lowthert LA, Ghori N, Omary MB (1995)."The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner".J. Biol. Chem.270(2): 915–22.doi:10.1074/jbc.270.2.915.PMID7529764.
• Yoon SJ, LeBlanc-Straceski J, Ward D, et al. (1995)."Organization of the human keratin type II gene cluster at 12q13".Genomics.24(3): 502–8.doi:10.1006/geno.1994.1659.PMID7536183.
• Ku NO, Omary MB (1995)."Identification and mutational analysis of the glycosylation sites of human keratin 18".J. Biol. Chem.270(20): 11820–7.doi:10.1074/jbc.270.20.11820.PMID7538124.
• Neumaier M, Gerhard M, Wagener C (1995). "Diagnosis of micrometastases by the amplification of tissue-specific genes".Gene.159(1): 43–7.doi:10.1016/0378-1119(94)00522-T.PMID7541767.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides".Gene.138(1–2): 171–4.doi:10.1016/0378-1119(94)90802-8.PMID8125298.
• Liao J, Lowthert LA, Ku NO, et al. (1996)."Dynamics of human keratin 18 phosphorylation: polarized distribution of phosphorylated keratins in simple epithelial tissues".J. Cell Biol.131(5): 1291–301.doi:10.1083/jcb.131.5.1291.PMC2120635.PMID8522590.
• Ku NO, Wright TL, Terrault NA, et al. (1997)."Mutation of human keratin 18 in association with cryptogenic cirrhosis".J. Clin. Invest.99(1): 19–23.doi:10.1172/JCI119127.PMC507762.PMID9011570.
• Ji H, Reid GE, Moritz RL, et al. (1997). "A two-dimensional gel database of human colon carcinoma proteins".Electrophoresis.18(3–4): 605–13.doi:10.1002/elps.1150180344.PMID9150948.S2CID25454450.