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Kim Sung-Hou

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In thisKorean name,the family name isKim.
Kim Sung-Hou
Born1937 (age 86–87)
Korea
NationalityAmerican
Alma materSeoul National University(B.S., 1960)(M.S., 1962)
University of Pittsburgh(Ph.D, 1966)
Occupation(s)Structural biologist and biophysicist
AwardsFulbright Fellowship(1962)

Guggenheim Fellowship(1985) Ernest O. Lawrence Award(1987)

Princess Takamatsu Award(1989)

Ho-am Prize(1994)
Korean name
Hangul
김성호
Hanja
Revised RomanizationGim Seongho
McCune–ReischauerKim Sǒngho

Kim Sung-Hou(born 1937) is aKorean-born Americanstructural biologistandbiophysicist.Kim reported the first 3D structure oftRNAwithA. Richin 1973.[1]He also published many papers on the structures of protein molecules including humanRas,[2]human cyclin dependent kinase 2 and small heat shock protein. He is a member of the U.S.National Academy of Sciencesand a fellow of the American Academy of Arts and Sciences since 1994. He is currently a professor in the department of chemistry at theU.C. Berkeleyand a faculty scientist atLawrence Berkeley National Laboratory (LBL).

Biography

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Kim Sung-Hou was born in Korea (1937). He obtained his B.S. (1960) and M.S. (1962) in chemistry fromSeoul National University,South Korea,and his PhD in 1966 from theUniversity of Pittsburgh.From 1966 to 1970 he was a research associate at theMassachusetts Institute of TechnologyunderAlexander Rich,and a senior research scientist there from 1970 to 1972, also with Rich.

From 1972 to 1978, he served as assistant and associate professor at the department of biochemistry,Duke University School of Medicine,and as professor at the department of chemistry,University of California, Berkeley,from 1978 to present.

Controversy over structure of tRNA

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Main article:tRNA history

There was some intense competition among several groups worldwide for solving the 3D structure of tRNA during the sixties and early seventies. The final round was between MIT'sRichgroup andAaron Klug's group at Cambridge. Kim, while at MIT, first published the 4Å backbone structure inSciencein 1973.[1]The next year, Rich's group came up with the 3Å structure.[3]

At a symposium held in June 1974, both Rich and Robertus from Klug's group presented their results with little detail. Afterwards Klug's group argued and complained toFrancis Crickthat Rich's group published a paper inScience[4]within a month of the symposium influenced by what they had heard which differed in some details from Rich's earlier 3 Å structure.[3]Two weeks later aNaturepaper by Klug's group presented their 3 Å structure.[5]Crick wrote to Rich concerning Klug's accusation.[6]However, Rich denied any scientific misconduct.[7]

The controversy arose from Klug's group not realizing that there were two tRNA models in the US: the MIT model (produced by Rich's team) and the Duke model (produced by Kim's team; Kim had moved to Duke University in 1972). There had been a breakdown of communication between the MIT and Duke groups in 1973-1974, during which period the models were developed independently. TheSciencepaper in 1974[4]was based on the Duke model, which reconfirmed the correctness of the original backbone structure,[1]and revealed an atomic structure that differed in a few details from the MIT model[3]and, as it turned out, from the Cambridge model[5]as well. The existence of the Duke model was later recognized and acknowledged by Crick.[8]The controversy would have been resolved at the outset if it had been informed to Klug's group that the Science paper in 1974[4]was based specifically on the tRNA structural model of Kim's laboratory at Duke University, not on the MIT model.

Plexxikon

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In 2001, Kim co-foundedPlexxikonwith ProfessorJoseph SchlessingerofYale University.Plexxikon uses a pioneering structural biology-based platform as a technique for drug discovery and development.[9]

References

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  1. ^abcKim SH, Quigley GJ, Suddath FL, et al. (1973). "Three-dimensional structure of yeast phenylalanine transfer RNA: folding of the polynucleotide chain".Science.179(4070): 285–8.Bibcode:1973Sci...179..285K.doi:10.1126/science.179.4070.285.PMID4566654.S2CID28916938.
  2. ^Tong, L.; Milburn, MV; de Vos, AM; Kim, S.-H. (1989). "Structure of Ras Protein".Science.245(244): 244.Bibcode:1989Sci...245..244T.doi:10.1126/science.2665078.PMID2665078.
  3. ^abcSuddath FL, Quigley GJ, McPherson A, et al. (1974). "Three-dimensional structure of yeast phenylalanine transfer RNA at 3.0 angstroms resolution".Nature.248(443): 20–4.Bibcode:1974Natur.248...20S.doi:10.1038/248020a0.PMID4594440.S2CID4207841.
  4. ^abcKim SH, Suddath FL, Quigley GJ, et al. (1974). "Three-dimensional tertiary structure of yeast phenylalanine transfer RNA".Science.185(4149): 435–40.Bibcode:1974Sci...185..435K.doi:10.1126/science.185.4149.435.PMID4601792.S2CID16013012.
  5. ^abRobertus JD, Ladner JE, Finch JT, Rhodes D, et al. (1974). "Structure of yeast phenylalanine tRNA at 3 A resolution".Nature.250(467): 546–51.Bibcode:1974Natur.250..546R.doi:10.1038/250546a0.PMID4602655.S2CID3051032.
  6. ^Crick's first letter to A. Rich on the accusation, Jul 1974
  7. ^Rich's reply to Crick's first letter, Aug 1974
  8. ^Crick's second letter to Rich, Sept 1974
  9. ^Plexxikon web site
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