LGD-3303
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| Routes of administration | By mouth |
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| Formula | C16H14ClF3N2O |
| Molar mass | 342.75g·mol−1 |
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LGD-3303is a drug which acts as aselective androgen receptor modulator(SARM), with good oral bioavailability. It is a selective agonist for theandrogen receptor,producingfunctional selectivitywith effective dissociation ofanabolicandandrogeniceffects, acting as a partial agonist for androgenic effects, but a full agonist for anabolic effects.[1]It has been investigated as a possible treatment forosteoporosis,and was shown in animal studies to enhance the effectiveness of abisphosphonatedrug.[2]
References
[edit]- ^Vajda EG, López FJ, Rix P, Hill R, Chen Y, Lee KJ, et al. (February 2009)."Pharmacokinetics and pharmacodynamics of LGD-3303 [9-chloro-2-ethyl-1-methyl-3-(2,2,2-trifluoroethyl)-3H-pyrrolo-[3,2-f]quinolin-7(6H)-one], an orally available nonsteroidal-selective androgen receptor modulator".The Journal of Pharmacology and Experimental Therapeutics.328(2): 663–70.doi:10.1124/jpet.108.146811.PMID19017848.S2CID22107491.
- ^Vajda EG, Hogue A, Griffiths KN, Chang WY, Burnett K, Chen Y, et al. (February 2009)."Combination treatment with a selective androgen receptor modulator q(SARM) and a bisphosphonate has additive effects in osteopenic female rats".Journal of Bone and Mineral Research.24(2): 231–40.doi:10.1359/jbmr.081007.PMID18847323.S2CID21995180.
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