LPAR3

LPAR3
Identifiers
Aliases	LPAR3,EDG7, Edg-7, GPCR, HOFNH30, LP-A3, LPA3, RP4-678I3, lysophosphatidic acid receptor 3
External IDs	OMIM:605106;MGI:1929469;HomoloGene:8123;GeneCards:LPAR3;OMA:LPAR3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p22.3 Start 84,811,602bp End 84,893,206bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 H2|3 71.03 cM Start 145,926,718bp End 145,991,941bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in bronchial epithelial cell right uterine tube mucosa of paranasal sinus spinal ganglia olfactory zone of nasal mucosa trigeminal ganglion atrium right auricle myocardium cardiac muscle tissue of right atrium Top expressed in lumbar spinal ganglion endocardial cushion right kidney membranous bone Dermatocranium maxilla mandible vestibular membrane of cochlear duct atrioventricular junction atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity lysophosphatidic acid receptor activity G-protein alpha-subunit binding phospholipid binding lipid binding Cellular component integral component of membrane membrane integral component of plasma membrane axon plasma membrane Biological process chemical synaptic transmission positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway positive regulation of cytosolic calcium ion concentration G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger bleb assembly positive regulation of collateral sprouting signal transduction positive regulation of MAPK cascade positive regulation of calcium ion transport G protein-coupled receptor signaling pathway Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 23566 65086 Ensembl ENSG00000171517 ENSMUSG00000036832 UniProt Q9UBY5 Q9EQ31 RefSeq (mRNA) NM_012152 NM_022983 RefSeq (protein) NP_036284 NP_075359 Location (UCSC) Chr 1: 84.81 – 84.89 Mb Chr 3: 145.93 – 145.99 Mb PubMedsearch
Wikidata
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Lysophosphatidic acid receptor 3also known asLPA₃is aproteinthat in humans is encoded by theLPAR3gene.LPA₃is aG protein-coupled receptorthat binds the lipid signaling moleculelysophosphatidic acid(LPA).

Function

This gene encodes a member of the G protein-coupled receptor family, as well as the EDG family of proteins. This protein functions as a cellular receptor for lysophosphatidic acid and mediates lysophosphatidic acid-evoked calcium mobilization. This receptor couples predominantly to G(q/11) alpha proteins.

Evolution

Paralogues

• LPAR1
• LPAR2
• S1PR1
• S1PR3
• S1PR4
• S1PR2
• S1PR5
• CNR1
• GPR3
• MC5R
• GPR6
• GPR12
• MC4R
• CNR2
• MC3R
• MC1R
• MC2R
• GPR119

See also

• Lysophospholipid receptor

Further reading

• Contos JJ, Ishii I, Chun J (2001). "Lysophosphatidic acid receptors".Mol. Pharmacol.58(6): 1188–96.doi:10.1124/mol.58.6.1188.PMID11093753.S2CID6936621.
• Im DS, Heise CE, Harding MA, et al. (2000). "Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate".Mol. Pharmacol.57(4): 753–9.doi:10.1124/mol.57.4.753.PMID10727522.
• Fitzgerald LR, Dytko GM, Sarau HM, et al. (2000). "Identification of an EDG7 variant, HOFNH30, a G-protein-coupled receptor for lysophosphatidic acid".Biochem. Biophys. Res. Commun.273(3): 805–10.doi:10.1006/bbrc.2000.2943.PMID10891327.
• Tokumura A, Sinomiya J, Kishimoto S, et al. (2002)."Human platelets respond differentially to lysophosphatidic acids having a highly unsaturated fatty acyl group and alkyl ether-linked lysophosphatidic acids".Biochem. J.365(Pt 3): 617–28.doi:10.1042/BJ20020348.PMC1222725.PMID11982483.
• Hama K, Bandoh K, Kakehi Y, et al. (2002)."Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors".FEBS Lett.523(1–3): 187–92.doi:10.1016/S0014-5793(02)02976-9.PMID12123830.S2CID44924895.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Cremers B, Flesch M, Kostenis E, et al. (2003). "Modulation of myocardial contractility by lysophosphatidic acid (LPA)".J. Mol. Cell. Cardiol.35(1): 71–80.doi:10.1016/S0022-2828(02)00279-1.PMID12623301.
• Fujita T, Miyamoto S, Onoyama I, et al. (2003). "Expression of lysophosphatidic acid receptors and vascular endothelial growth factor mediating lysophosphatidic acid in the development of human ovarian cancer".Cancer Lett.192(2): 161–9.doi:10.1016/S0304-3835(02)00713-9.PMID12668280.
• Jin Y, Knudsen E, Wang L, Maghazachi AA (2003)."Lysophosphatidic acid induces human natural killer cell chemotaxis and intracellular calcium mobilization".Eur. J. Immunol.33(8): 2083–9.doi:10.1002/eji.200323711.PMID12884281.S2CID41960806.
• Xing Y, Ganji SH, Noh JW, Kamanna VS (2005). "Cell density-dependent expression of EDG family receptors and mesangial cell proliferation: role in lysophosphatidic acid-mediated cell growth".Am. J. Physiol. Renal Physiol.287(6): F1250–7.doi:10.1152/ajprenal.00342.2003.PMID15292052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.

External links

• "Lysophospholipid Receptors: LPA₃".IUPHAR Database of Receptors and Ion Channels.International Union of Basic and Clinical Pharmacology. Archived fromthe originalon 2016-03-03.Retrieved2008-12-05.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.