Latrophilin 3

ADGRL3
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 5CMN,5AFB
Identifiers
Aliases	ADGRL3,CIRL3, LEC3, CL3, LPHN3, adhesion G protein-coupled receptor L3
External IDs	OMIM:616417;MGI:2441950;HomoloGene:22878;GeneCards:ADGRL3;OMA:ADGRL3 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) Band 4q13.1 Start 61,201,258bp End 62,078,335bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 D-E1 Start 81,020,138bp End 81,825,133bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in hair follicle saphenous vein middle temporal gyrus endothelial cell entorhinal cortex Pars compacta superior vestibular nucleus orbitofrontal cortex Achilles tendon Brodmann area 23 Top expressed in Region I of hippocampus proper otolith organ utricle ventromedial nucleus substantia nigra anterior amygdaloid area lateral septal nucleus lateral hypothalamus medial geniculate nucleus olfactory tubercle More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity metal ion binding protein binding transmembrane signaling receptor activity carbohydrate binding calcium ion binding Cellular component integral component of membrane cell projection membrane cell-cell junction plasma membrane axon cell junction integral component of plasma membrane glutamatergic synapse intracellular anatomical structure Biological process response to cocaine G protein-coupled receptor signaling pathway neuron migration cell surface receptor signaling pathway synapse assembly locomotion involved in locomotory behavior signal transduction positive regulation of synapse assembly cell-cell adhesion via plasma-membrane adhesion molecules synapse organization adenylate cyclase-activating G protein-coupled receptor signaling pathway brain development Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 23284 319387 Ensembl ENSG00000150471 ENSMUSG00000037605 UniProt Q9HAR2 Q80TS3 RefSeq (mRNA) NM_015236 NM_001322246 NM_001322402 NM_001371342 NM_001371343 NM_001371344 NM_001371345 NM_001371346 NM_198702 NM_001347367 NM_001347368 NM_001347369 NM_001347371 NM_001359826 NM_001359828 NM_001359829 NM_001359830 NM_001359831 NM_001359832 NM_001359833 NM_001359834 RefSeq (protein) NP_001309175 NP_001309331 NP_056051 NP_001358271 NP_001358272 NP_001358273 NP_001358274 NP_001358275 NP_001334296 NP_001334297 NP_001334298 NP_001334300 NP_941991 NP_001346755 NP_001346757 NP_001346758 NP_001346759 NP_001346760 NP_001346761 NP_001346762 NP_001346763 Location (UCSC) Chr 4: 61.2 – 62.08 Mb Chr 5: 81.02 – 81.83 Mb PubMedsearch
Wikidata
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Latrophilin 3is aproteinthat in humans is encoded by theADGRL3gene.

Function

This gene encodes a member of thelatrophilinsubfamily ofG protein-coupled receptors(GPCR). Latrophilins may function in bothcell adhesionandsignal transduction.In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellularN-terminalcell adhesion subunit and a subunit with substantial similarity to thesecretin/calcitonin familyof GPCRs) being non-covalently bound at the cell membrane.

Clinical significance

A version of this gene has been linked toattention deficit hyperactivity disorder(ADHD).

See also

• Adhesion G protein-coupled receptors

Further reading

• Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins".Annual Review of Neuroscience.24:933–62.doi:10.1146/annurev.neuro.24.1.933.PMID11520923.
• Ushkaryov YA, Volynski KE, Ashton AC (Apr 2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies".Toxicon.43(5): 527–42.doi:10.1016/j.toxicon.2004.02.008.PMID15066411.
• Soares MB, Bonaldo MF, Jelene P, Su L, Lawton L, Efstratiadis A (Sep 1994)."Construction and characterization of a normalized cDNA library".Proceedings of the National Academy of Sciences of the United States of America.91(20): 9228–32.Bibcode:1994PNAS...91.9228S.doi:10.1073/pnas.91.20.9228.PMC44785.PMID7937745.
• Sanger Centre, The; Washington University Genome Sequencing Cente, The (Nov 1998)."Toward a complete human genome sequence".Genome Research.8(11): 1097–108.doi:10.1101/gr.8.11.1097.PMID9847074.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Oct 1998)."Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro".DNA Research.5(5): 277–86.doi:10.1093/dnares/5.5.277.PMID9872452.
• Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM (Oct 2000)."The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins".The Journal of Biological Chemistry.275(42): 32387–90.doi:10.1074/jbc.C000490200.PMID10964907.
• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (Jul 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors".Genomics.84(1): 23–33.doi:10.1016/j.ygeno.2003.12.004.PMID15203201.

External links

• PDBe-KBprovides an overview of all the structure information available in the PDB for Human Adhesion G protein-coupled receptor L3
• PDBe-KBprovides an overview of all the structure information available in the PDB for Mouse Adhesion G protein-coupled receptor L3

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.