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Louis Hodes

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Louis Hodes
Born(1934-06-19)19 June 1934
New York City,United States
Died19 June 2008(2008-06-19)(aged 74)
Bethesda, Maryland
CitizenshipUnited States
EducationB.S.,Polytechnic Institute of Brooklyn
Ph.D.,MIT(1962)
Known forLisp
Pattern recognition
Logic programming
Scientific career
FieldsMathematics
Computer science
Cancer research
InstitutionsMassachusetts Institute of Technology
National Institutes of Health
National Cancer Institute
ThesisHyperarithmetical Real Numbers and Hyperarithmetical Analysis(1962)
Doctoral advisorHartley Rogers

Louis Hodes(June 19, 1934 – June 30, 2008) was an Americanmathematician,computer scientist,andcancer researcher.[1]

Early life and computer science work

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Louis Hodes got hisBachelor of Science(B.S.) from thePolytechnic Institute of Brooklyn.He got hisDoctor of Philosophy(Ph.D.) from theMassachusetts Institute of Technology(MIT) in 1962, underHartley Rogerswith a thesis oncomputability.[1]WithJohn McCarthy,in the late 1950s and early 1960s, he helped produce the earliest implementations of the programming languageLisp,[2] and underMarvin Minskyhe did early research on visualpattern recognitionin Lisp.[3][4][5]He is also credited by some with the idea, and an initial implementation, oflogic programming.[1][6][7][8]

Cancer research

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In 1966 he moved into cancer-related research, specifically atNational Institutes of Healthand later theNational Cancer Institutewhere he turned his interest in visual pattern recognition tomedical imagingapplications.[1][9]He also worked on efficient algorithms for screening chemical compounds for studying chemical carcinogenesis.[1][10][11][12][13][14]His work on models of clustering for chemical compounds was pronounced a "milestone" by the Developmental Therapeutics Program of the National Cancer Institute, for "revolutioniz[ing] the selection of compounds of interest by measuring the novelty of a chemical structure by comparing it to known compounds."[15]

References

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  1. ^abcde"Obituaries: Louis Hodes: Scientist".The Washington Post.1 Aug 2008.
  2. ^McCarthy, J.;Brayton, R.; Edwards, D.;Fox, P.;Hodes, L.;Luckham, D.;Maling, K.;Park, D.;Russell, S.(March 1960),LISP I Programmers Manual(PDF),Boston,Massachusetts:Artificial Intelligence Group,M.I.T. Computation Centerand Research Laboratory, archived fromthe original(PDF)on 2010-07-17,retrieved11 May2010
  3. ^MIT research summary report, ch.XVI: Artificial Intelligence, p.166
  4. ^"Artificial Intelligence Project – RLE and MIT Computation Center Memo 18 – Some results from a pattern recognition program using LISP", undated memo,[1]
  5. ^Hodes, L. "Machine Processing of Line Drawings", M.I.T. Lincoln Laboratory Report, 54G-0028 March 1961
  6. ^Minker, Jack(1988)."Perspectives in deductive databases".The Journal of Logic Programming.5:33–60.doi:10.1016/0743-1066(88)90006-4.
  7. ^Lobo, Jorge; Minker, Jack; Rajasekar, Arcot (1992).Foundations of Disjunctive Logic Programming.MIT Press. p. 19.ISBN978-0-262-12165-1.
  8. ^Hodes, L. Hodes (1966)."Programming languages, logic and cooperative games".Proceedings of the first ACM symposium on Symbolic and algebraic manipulation.pp. 1201–1217.
  9. ^"A programming system for the on-line analysis of biomedical images",Communications of the ACMv.13, #5 (May 1970) pp. 279–283ISSN0001-0782[2]
  10. ^Feldman, Alfred; Hodes, Louis (1979)."Substructure Search with Queries of Varying Specificity".Journal of Chemical Information and Computer Sciences.19(3): 125–129.doi:10.1021/ci60019a003.
  11. ^Hodes, Louis (1986)."A two-component approach to predicting antitumor activity from chemical structure in large-scale screening".Journal of Medicinal Chemistry.29(11): 2207–2212.doi:10.1021/jm00161a013.PMID3783583.
  12. ^Hodes, Louis (1989)."Clustering a large number of compounds. 1. Establishing the method on an initial sample".Journal of Chemical Information and Computer Sciences.29(2): 66–71.doi:10.1021/ci00062a004.PMID2745581.
  13. ^Hodes, Louis (1981)."Selection of molecular fragment features for structure-activity studies in antitumor screening".Journal of Chemical Information and Computer Sciences.21(3): 132–136.doi:10.1021/ci00031a004.PMID7287834.
  14. ^Hodes, Louis (1981)."Computer-aided selection of compounds for antitumor screening: Validation of a statistical-heuristic method".Journal of Chemical Information and Computer Sciences.21(3): 128–132.doi:10.1021/ci00031a003.PMID7287833.
  15. ^"Milestone (1981): Hodes model for ranking small molecule structures (sic)", www.cancer.gov[3]
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