MAPK13
Mitogen-activated protein kinase 13(MAPK 13), also known asstress-activated protein kinase 4(SAPK4), is anenzymethat in humans is encoded by theMAPK13gene.[5]
Function
[edit]The protein encoded by this gene is a member of theMAP kinasefamily. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such asproliferation,differentiation,transcriptionregulation anddevelopment.This kinase is closely related top38 MAP kinase,both of which can be activated by proinflammatorycytokinesand cellular stress. MAP kinase kinases 3, and 6 canphosphorylateand activate this kinase. Transcription factorATF2,and microtubule dynamics regulatorstathminhave been shown to be thesubstratesof this kinase.[5]
References
[edit]- ^abcGRCh38: Ensembl release 89: ENSG00000156711–Ensembl,May 2017
- ^abcGRCm38: Ensembl release 89: ENSMUSG00000004864–Ensembl,May 2017
- ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ab"Entrez Gene: mitogen-activated protein kinase 13".
Further reading
[edit]- Efimova T, Broome AM, Eckert RL (2004)."Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex".Mol. Cell. Biol.24(18): 8167–83.doi:10.1128/MCB.24.18.8167-8183.2004.PMC515052.PMID15340077.
- Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis".J. Mol. Med.75(8): 587–93.doi:10.1007/s001090050143.PMID9297626.S2CID23541383.
- Efimova T (2010)."p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis".Cell Cycle.9(3): 498–05.doi:10.4161/cc.9.3.10541.PMID20090411.
- Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008)."Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I."J. Gen. Virol.89(Pt 7): 1661–71.doi:10.1099/vir.0.82971-0.PMID18559936.
- Zhang J, Harrison JS, Studzinski GP (2011)."Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃".Exp. Cell Res.317(1): 117–30.doi:10.1016/j.yexcr.2010.08.010.PMC2998239.PMID20804750.
- Segat L, Brandão LA, Guimarães RL, et al. (2010)."Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment".Vaccine.28(10): 2201–6.doi:10.1016/j.vaccine.2009.12.056.PMID20056178.
- Zhou X, Ferraris JD, Dmitrieva NI, et al. (2008)."MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta".Proc. Natl. Acad. Sci. U.S.A.105(14): 5620–5.Bibcode:2008PNAS..105.5620Z.doi:10.1073/pnas.0801453105.PMC2291081.PMID18367666.
- Coulthard LR, Taylor JC, Eyre S, et al. (2011). "Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients".Ann. Rheum. Dis.70(1): 98–103.doi:10.1136/ard.2010.133249.PMID20805296.S2CID37511360.
- Efimova T, Broome AM, Eckert RL (2003)."A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation".J. Biol. Chem.278(36): 34277–85.doi:10.1074/jbc.M302759200.PMID12810719.
- Kim SJ, Zhang Z, Hitomi E, et al. (2006)."Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL".Hum. Mol. Genet.15(11): 1826–34.doi:10.1093/hmg/ddl105.PMID16644870.
- Talmud PJ, Drenos F, Shah S, et al. (2009)."Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip".Am. J. Hum. Genet.85(5): 628–42.doi:10.1016/j.ajhg.2009.10.014.PMC2775832.PMID19913121.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425(6960): 805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID14574404.
- Colland F, Jacq X, Trouplin V, et al. (2004)."Functional proteomics mapping of a human signaling pathway".Genome Res.14(7): 1324–32.doi:10.1101/gr.2334104.PMC442148.PMID15231748.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
- Ozawa S, Ito S, Kato Y, et al. (2010). "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14".Biochem. Biophys. Res. Commun.396(4): 1060–4.doi:10.1016/j.bbrc.2010.05.072.PMID20478268.
- Kitatani K, Sheldon K, Anelli V, et al. (2009)."Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid".J. Biol. Chem.284(19): 12979–88.doi:10.1074/jbc.M809500200.PMC2676030.PMID19279008.
- Tan FL, Ooi A, Huang D, et al. (2010)."p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion".Int. J. Cancer.126(10): 2353–61.doi:10.1002/ijc.24944.PMID19816939.S2CID34276751.
- Sofroniew MV, Howe CL,Mobley WC(2001). "Nerve growth factor signaling, neuroprotection, and neural repair".Annu. Rev. Neurosci.24:1217–81.doi:10.1146/annurev.neuro.24.1.1217.PMID11520933.
- Bailey SD, Xie C, Do R, et al. (2010)."Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study".Diabetes Care.33(10): 2250–3.doi:10.2337/dc10-0452.PMC2945168.PMID20628086.
- Sumara G, Formentini I, Collins S, et al. (2009)."Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis".Cell.136(2): 235–48.doi:10.1016/j.cell.2008.11.018.PMC2638021.PMID19135240.
This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.