MAPK13

MAPK13
Available structures PDB Ortholog search:PDBeRCSB List of PDB id codes 3COI,4EYJ,4EYM,4MYG,4YNO,5EKO,5EKN
Identifiers
Aliases	MAPK13,MAPK 13, MAPK-13, PRKM13, SAPK4, p38delta, mitogen-activated protein kinase 13
External IDs	OMIM:602899;MGI:1346864;HomoloGene:48133;GeneCards:MAPK13;OMA:MAPK13 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.31 Start 36,127,809bp End 36,144,524bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A3.3 Start 28,988,271bp End 28,999,207bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gums mucosa of transverse colon right adrenal gland right adrenal cortex gingival epithelium left adrenal gland mucosa of ileum human penis left adrenal cortex parotid gland Top expressed in granulocyte lip crypt of lieberkuhn of small intestine epithelium of stomach duodenum large intestine ileum colon intestinal villus jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity MAP kinase activity kinase activity protein serine/threonine kinase activity protein binding ATP binding Cellular component cytosol nucleus cytoplasm Biological process positive regulation of inflammatory response regulation of transcription, DNA-templated phosphorylation transcription, DNA-templated response to osmotic stress protein phosphorylation peptidyl-serine phosphorylation positive regulation of interleukin-6 production cell cycle regulation of gene expression cellular response to UV stress-activated MAPK cascade cellular response to hydrogen peroxide cellular response to interleukin-1 cellular response to sorbitol cellular response to anisomycin cellular response to sodium arsenite MAPK cascade intracellular signal transduction cellular response to organic substance Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 5603 26415 Ensembl ENSG00000156711 ENSMUSG00000004864 UniProt O15264 Q9Z1B7 RefSeq (mRNA) NM_002754 NM_011950 RefSeq (protein) NP_002745 NP_036080 Location (UCSC) Chr 6: 36.13 – 36.14 Mb Chr 17: 28.99 – 29 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Mitogen-activated protein kinase 13(MAPK 13), also known asstress-activated protein kinase 4(SAPK4), is anenzymethat in humans is encoded by theMAPK13gene.

Function

The protein encoded by this gene is a member of theMAP kinasefamily. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such asproliferation,differentiation,transcriptionregulation anddevelopment.This kinase is closely related top38 MAP kinase,both of which can be activated by proinflammatorycytokinesand cellular stress. MAP kinase kinases 3, and 6 canphosphorylateand activate this kinase. Transcription factorATF2,and microtubule dynamics regulatorstathminhave been shown to be thesubstratesof this kinase.

Further reading

• Efimova T, Broome AM, Eckert RL (2004)."Protein kinase Cdelta regulates keratinocyte death and survival by regulating activity and subcellular localization of a p38delta-extracellular signal-regulated kinase 1/2 complex".Mol. Cell. Biol.24(18): 8167–83.doi:10.1128/MCB.24.18.8167-8183.2004.PMC515052.PMID15340077.
• Joneson T, Bar-Sagi D (1997). "Ras effectors and their role in mitogenesis and oncogenesis".J. Mol. Med.75(8): 587–93.doi:10.1007/s001090050143.PMID9297626.S2CID23541383.
• Efimova T (2010)."p38delta mitogen-activated protein kinase regulates skin homeostasis and tumorigenesis".Cell Cycle.9(3): 498–05.doi:10.4161/cc.9.3.10541.PMID20090411.
• Gutierrez-Sanmartin D, Varela-Ledo E, Aguilera A, et al. (2008)."Implication of p38 mitogen-activated protein kinase isoforms (alpha, beta, gamma and delta) in CD4+ T-cell infection with human immunodeficiency virus type I."J. Gen. Virol.89(Pt 7): 1661–71.doi:10.1099/vir.0.82971-0.PMID18559936.
• Zhang J, Harrison JS, Studzinski GP (2011)."Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃".Exp. Cell Res.317(1): 117–30.doi:10.1016/j.yexcr.2010.08.010.PMC2998239.PMID20804750.
• Segat L, Brandão LA, Guimarães RL, et al. (2010)."Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment".Vaccine.28(10): 2201–6.doi:10.1016/j.vaccine.2009.12.056.PMID20056178.
• Zhou X, Ferraris JD, Dmitrieva NI, et al. (2008)."MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta".Proc. Natl. Acad. Sci. U.S.A.105(14): 5620–5.Bibcode:2008PNAS..105.5620Z.doi:10.1073/pnas.0801453105.PMC2291081.PMID18367666.
• Coulthard LR, Taylor JC, Eyre S, et al. (2011). "Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients".Ann. Rheum. Dis.70(1): 98–103.doi:10.1136/ard.2010.133249.PMID20805296.S2CID37511360.
• Efimova T, Broome AM, Eckert RL (2003)."A regulatory role for p38 delta MAPK in keratinocyte differentiation. Evidence for p38 delta-ERK1/2 complex formation".J. Biol. Chem.278(36): 34277–85.doi:10.1074/jbc.M302759200.PMID12810719.
• Kim SJ, Zhang Z, Hitomi E, et al. (2006)."Endoplasmic reticulum stress-induced caspase-4 activation mediates apoptosis and neurodegeneration in INCL".Hum. Mol. Genet.15(11): 1826–34.doi:10.1093/hmg/ddl105.PMID16644870.
• Talmud PJ, Drenos F, Shah S, et al. (2009)."Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip".Am. J. Hum. Genet.85(5): 628–42.doi:10.1016/j.ajhg.2009.10.014.PMC2775832.PMID19913121.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003)."The DNA sequence and analysis of human chromosome 6".Nature.425(6960): 805–11.Bibcode:2003Natur.425..805M.doi:10.1038/nature02055.PMID14574404.
• Colland F, Jacq X, Trouplin V, et al. (2004)."Functional proteomics mapping of a human signaling pathway".Genome Res.14(7): 1324–32.doi:10.1101/gr.2334104.PMC442148.PMID15231748.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Ozawa S, Ito S, Kato Y, et al. (2010). "Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14".Biochem. Biophys. Res. Commun.396(4): 1060–4.doi:10.1016/j.bbrc.2010.05.072.PMID20478268.
• Kitatani K, Sheldon K, Anelli V, et al. (2009)."Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid".J. Biol. Chem.284(19): 12979–88.doi:10.1074/jbc.M809500200.PMC2676030.PMID19279008.
• Tan FL, Ooi A, Huang D, et al. (2010)."p38delta/MAPK13 as a diagnostic marker for cholangiocarcinoma and its involvement in cell motility and invasion".Int. J. Cancer.126(10): 2353–61.doi:10.1002/ijc.24944.PMID19816939.S2CID34276751.
• Sofroniew MV, Howe CL,Mobley WC(2001). "Nerve growth factor signaling, neuroprotection, and neural repair".Annu. Rev. Neurosci.24:1217–81.doi:10.1146/annurev.neuro.24.1.1217.PMID11520933.
• Bailey SD, Xie C, Do R, et al. (2010)."Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study".Diabetes Care.33(10): 2250–3.doi:10.2337/dc10-0452.PMC2945168.PMID20628086.
• Sumara G, Formentini I, Collins S, et al. (2009)."Regulation of PKD by the MAPK p38delta in insulin secretion and glucose homeostasis".Cell.136(2): 235–48.doi:10.1016/j.cell.2008.11.018.PMC2638021.PMID19135240.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.