From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
MAP kinase-interacting serine/threonine-protein kinase 2 is anenzyme that in humans is encoded by theMKNK2 gene .[ 5] [ 6]
MNK2 has been shown tointeract withMAPK1 [ 7] [ 8] andEukaryotic translation initiation factor 4 gamma .[ 7]
MNK2 has been identified as a therapeutic target fordiabetes .Specifically, blocking MNK2 interaction with eIF4G has been shown to boost protein synthesis and promotebeta cell regeneration.[ 9]
^a b c GRCh38: Ensembl release 89: ENSG00000099875 –Ensembl ,May 2017
^a b c GRCm38: Ensembl release 89: ENSMUSG00000020190 –Ensembl ,May 2017
^ "Human PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" .National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (October 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta".Genomics .69 (1): 63–71.doi :10.1006/geno.2000.6299 .PMID 11013076 .
^ "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2" .
^a b Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003)."The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization" .Molecular and Cellular Biology .23 (16): 5692–5705.doi :10.1128/MCB.23.16.5692-5705.2003 .PMC 166352 .PMID 12897141 .
^ Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997)."Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2" .The EMBO Journal .16 (8): 1909–1920.doi :10.1093/emboj/16.8.1909 .PMC 1169794 .PMID 9155017 .
^ Karampelias C, Watt K, Mattsson CL, Ruiz ÁF, Rezanejad H, Mi J, et al. (September 2022)."MNK2 deficiency potentiates β-cell regeneration via translational regulation" .Nature Chemical Biology .18 (9): 942–953.doi :10.1038/s41589-022-01047-x .PMC 7613404 .PMID 35697798 .
Haribabu B, Snyderman R (October 1993)."Identification of additional members of human G-protein-coupled receptor kinase multigene family" .Proceedings of the National Academy of Sciences of the United States of America .90 (20): 9398–9402.Bibcode :1993PNAS...90.9398H .doi :10.1073/pnas.90.20.9398 .PMC 47575 .PMID 8415712 .
Bonaldo MF, Lennon G, Soares MB (September 1996)."Normalization and subtraction: two approaches to facilitate gene discovery" .Genome Research .6 (9): 791–806.doi :10.1101/gr.6.9.791 .PMID 8889548 .
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA (April 1997)."Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2" .The EMBO Journal .16 (8): 1909–1920.doi :10.1093/emboj/16.8.1909 .PMC 1169794 .PMID 9155017 .
Scheper GC, Morrice NA, Kleijn M, Proud CG (February 2001)."The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells" .Molecular and Cellular Biology .21 (3): 743–754.doi :10.1128/MCB.21.3.743-754.2001 .PMC 86666 .PMID 11154262 .
Knauf U, Tschopp C, Gram H (August 2001)."Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2" .Molecular and Cellular Biology .21 (16): 5500–5511.doi :10.1128/MCB.21.16.5500-5511.2001 .PMC 87272 .PMID 11463832 .
Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (August 2003)."The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization" .Molecular and Cellular Biology .23 (16): 5692–5705.doi :10.1128/MCB.23.16.5692-5705.2003 .PMC 166352 .PMID 12897141 .
Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL (September 2005)."Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway" .Journal of Virology .79 (17): 11366–11381.doi :10.1128/JVI.79.17.11366-11381.2005 .PMC 1193619 .PMID 16103188 .
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network".Nature .437 (7062): 1173–1178.Bibcode :2005Natur.437.1173R .doi :10.1038/nature04209 .PMID 16189514 .S2CID 4427026 .
Jauch R, Jäkel S, Netter C, Schreiter K, Aicher B, Jäckle H, Wahl MC (October 2005). "Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site".Structure .13 (10): 1559–1568.doi :10.1016/j.str.2005.07.013 .hdl :11858/00-001M-0000-0010-9408-D .PMID 16216586 .
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes" .Genome Research .16 (1): 55–65.doi :10.1101/gr.4039406 .PMC 1356129 .PMID 16344560 .
Wang P, Wang X, Wang F, Cai T, Luo Y (June 2006). "Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex".Science in China Series C: Life Sciences .49 (3): 265–273.doi :10.1007/s11427-006-0265-5 .PMID 16856496 .S2CID 23339861 .
PDB gallery
2ac3 :Structure of human Mnk2 Kinase Domain
2ac5 :Structure of human Mnk2 Kinase Domain mutant D228G
2hw7 :Crystal Structure of Mnk2-D228G in complex with Staurosporine
Activity Regulation Classification Kinetics Types