MYO18A

MYO18A
Identifiers
Aliases	MYO18A,MYSPDZ, SPR210, myosin XVIIIA, MAJN, SP-R210
External IDs	OMIM:610067;MGI:2667185;HomoloGene:7977;GeneCards:MYO18A;OMA:MYO18A - orthologs
Gene location (Human) Chr. Chromosome 17 (human) Band 17q11.2 Start 29,071,122bp End 29,180,398bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11|11 B5 Start 77,763,246bp End 77,865,980bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue apex of heart muscle of thigh sural nerve right auricle left ventricle corpus callosum right lobe of liver epithelium of colon Top expressed in muscle of thigh esophagus lip triceps brachii muscle ankle right ventricle temporal muscle skeletal muscle tissue intestinal villus neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding nucleotide binding ADP binding actin filament binding ATPase activity protein binding ATP binding RNA binding Cellular component cytoplasm membrane trans-Golgi network actomyosin cytoskeleton myosin complex endoplasmic reticulum-Golgi intermediate compartment Golgi membrane Golgi apparatus cell surface Biological process Golgi organization Golgi vesicle budding actomyosin structure organization DNA metabolic process asymmetric Golgi ribbon formation negative regulation of apoptotic process positive regulation of protein secretion cell migration Golgi ribbon formation regulation of macrophage activation positive regulation of opsonization Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 399687 360013 Ensembl ENSG00000196535 ENSMUSG00000000631 UniProt Q92614 Q9JMH9 RefSeq (mRNA) NM_001346765 NM_001346766 NM_001346767 NM_001346768 NM_078471 NM_203318 NM_001291212 NM_001291213 NM_001291214 NM_001291215 NM_011586 RefSeq (protein) NP_001333694 NP_001333695 NP_001333696 NP_001333697 NP_510880 NP_976063 NP_001278141 NP_001278142 NP_001278143 NP_001278144 NP_035716 Location (UCSC) Chr 17: 29.07 – 29.18 Mb Chr 11: 77.76 – 77.87 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Myosin-XVIIIais aproteinthat in humans is encoded by theMYO18Agene.

Further reading

• Chroneos ZC, Abdolrasulnia R, Whitsett JA, et al. (1996)."Purification of a cell-surface receptor for surfactant protein A."J. Biol. Chem.271(27): 16375–83.doi:10.1074/jbc.271.27.16375.PMID8663107.
• Nagase T, Seki N, Ishikawa K, et al. (1997)."Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain".DNA Res.3(5): 321–9, 341–54.doi:10.1093/dnares/3.5.321.PMID9039502.
• Chang NS, Mattison J, Cao H, et al. (1999). "Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity".Biochem. Biophys. Res. Commun.253(3): 743–9.doi:10.1006/bbrc.1998.9846.PMID9918798.
• Ji H, Zhai Q, Zhu J, et al. (2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis induced by IL-2 deprival".Biochem. Biophys. Res. Commun.270(1): 267–71.doi:10.1006/bbrc.2000.2413.PMID10733938.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003)."Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences".Proc. Natl. Acad. Sci. U.S.A.99(26): 16899–903.Bibcode:2002PNAS...9916899M.doi:10.1073/pnas.242603899.PMC139241.PMID12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004)."Complete sequencing and characterization of 21,243 full-length human cDNAs".Nat. Genet.36(1): 40–5.doi:10.1038/ng1285.PMID14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004)."Large-scale characterization of HeLa cell nuclear phosphoproteins".Proc. Natl. Acad. Sci. U.S.A.101(33): 12130–5.Bibcode:2004PNAS..10112130B.doi:10.1073/pnas.0404720101.PMC514446.PMID15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004)."The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)".Genome Res.14(10B): 2121–7.doi:10.1101/gr.2596504.PMC528928.PMID15489334.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain".J. Mol. Biol.343(5): 1207–20.doi:10.1016/j.jmb.2004.09.028.PMID15491607.
• Isogawa Y, Kon T, Inoue T, et al. (2005). "The N-terminal domain of MYO18A has an ATP-insensitive actin-binding site".Biochemistry.44(16): 6190–6.doi:10.1021/bi0475931.PMID15835906.
• Kim JE, Tannenbaum SR, White FM (2005). "Global phosphoproteome of HT-29 human colon adenocarcinoma cells".J. Proteome Res.4(4): 1339–46.doi:10.1021/pr050048h.PMID16083285.
• Yang CH, Szeliga J, Jordan J, et al. (2005)."Identification of the surfactant protein A receptor 210 as the unconventional myosin 18A".J. Biol. Chem.280(41): 34447–57.doi:10.1074/jbc.M505229200.PMC1762002.PMID16087679.
• Lim J, Hao T, Shaw C, et al. (2006)."A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration".Cell.125(4): 801–14.doi:10.1016/j.cell.2006.03.032.PMID16713569.S2CID13709685.
• Olsen JV, Blagoev B, Gnad F, et al. (2006)."Global, in vivo, and site-specific phosphorylation dynamics in signaling networks".Cell.127(3): 635–48.doi:10.1016/j.cell.2006.09.026.PMID17081983.S2CID7827573.