Menadiol
Appearance
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Names | |||
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Preferred IUPAC name
2-Methylnaphthalene-1,4-diol | |||
Other names
2-Methyl-1,4-naphthalenediol; 2-Methyl-1,4-dihydroxynaphthalene
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Identifiers | |||
3D model (JSmol)
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ChemSpider | |||
ECHA InfoCard | 100.006.886 | ||
PubChemCID
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UNII | |||
CompTox Dashboard(EPA)
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Properties | |||
C11H10O2 | |||
Molar mass | 174.199g·mol−1 | ||
Except where otherwise noted, data are given for materials in theirstandard state(at 25 °C [77 °F], 100 kPa).
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Menadiolis an organic compound with the formula C6H4(COH)2(CH)(CH3). It is formally a derivative of p-hydroquinone.The namevitamin K4can refer to:
Menadiol sodium diphosphate is approved in the UK for treatment and prevention of haemorrhage, mainly in obstructive jaundice (before and after surgery).[6]
Menadiol is probably naturally produced by reduction ofmenadione( "vitamin K3";seeQuinone § Reduction) as an intermediate in the conversion from K3toMK-4.[7]It can be oxidized in experimental conditions back to menadione.[8]
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The menadiol core is apparent in the structure ofvitamin K.
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Menadiol diacetate
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Menadiol dibutyrate
References
[edit]- ^Fiore LD, et al. (2001). "Anaphylactoid reactions to vitamin K".Journal of Thrombosis and Thrombolysis.11(2): 175–183.doi:10.1023/A:1011237019082.ISSN0929-5305.PMID11406734.S2CID975055.
- ^abcSebrell WH, et al. (1971).The vitamins; chemistry, physiology, pathology, methods(2nd ed.). Academic Press. p. 443.ISBN9780126337631.
- ^"Vitamin K2 added for nutritional purposes in foods for particular nutritional uses, food supplements and foods intended for the general population and Vitamin K2 as a source of vitamin K added for nutritional purposes to foodstuffs, in the context of Regulation (EC) N° 258/97".EFSA Journal.6(11): 822. 2008.doi:10.2903/j.efsa.2008.822.ISSN1831-4732.
- ^abcdOketch-Rabah HA, Roe AL, Marles RJ (2017)."US Pharmacopeial Convention safety evaluation of menaquinone-7, a form of vitamin K".Nutrition Reviews.75(7): 553–578.doi:10.1093/nutrit/nux022.ISSN0029-6643.PMID28838081.
- ^"Kappadione".go.drugbank.com.
- ^"Menadiol Diphosphate Tablets 10mg - Summary of Product Characteristics (SmPC) - (emc)".www.medicines.org.uk.
- ^Shearer, Martin J.; Newman, Paul (March 2014)."Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis".Journal of Lipid Research.55(3): 345–362.doi:10.1194/jlr.R045559.ISSN0022-2275.PMC3934721.PMID24489112.
- ^Weber F, Rüttimann A (2012). "Vitamin K".Ullmann's Encyclopedia Of Industrial Chemistry.Weinheim: Wiley-VCH.doi:10.1002/14356007.o27_o08.S2CID86263542.