Metabotropic glutamate receptor 8

GRM8
Identifiers
Aliases	GRM8,GLUR8, GPRC1H, MGLUR8, mGlu8, glutamate metabotropic receptor 8
External IDs	OMIM:601116;MGI:1351345;HomoloGene:654;GeneCards:GRM8;OMA:GRM8 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q31.33 Start 126,438,598bp End 127,253,093bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 A3.1- A3.2 Start 27,275,118bp End 28,135,177bp
RNA expressionpattern Bgee Human Mouse(ortholog) Top expressed in gonad testicle left testis right testis oocyte Epithelium of choroid plexus prefrontal cortex Brodmann area 9 corpus callosum cingulate gyrus Top expressed in ganglion cell layer secondary oocyte zygote inner nuclear layer superior frontal gyrus embryo primary visual cortex embryo outer nuclear layer dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function glutamate receptor activity G protein-coupled receptor activity signal transducer activity Cellular component integral component of membrane integral component of plasma membrane presynaptic membrane membrane plasma membrane Biological process adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway signal transduction visual perception response to stimulus regulation of synaptic transmission, glutamatergic G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled glutamate receptor signaling pathway Sources:Amigo/QuickGO
Orthologs Species Human Mouse Entrez 2918 14823 Ensembl ENSG00000179603 ENSMUSG00000024211 UniProt O00222 P47743 RefSeq (mRNA) NM_000845 NM_001127323 NM_001371083 NM_001371084 NM_001371085 NM_001371086 NM_001371087 NM_001371088 NM_008174 NM_001311072 NM_001361125 RefSeq (protein) NP_000836 NP_001120795 NP_001358012 NP_001358013 NP_001358014 NP_001358015 NP_001358016 NP_001358017 NP_001298001 NP_032200 NP_001348054 Location (UCSC) Chr 7: 126.44 – 127.25 Mb Chr 6: 27.28 – 28.14 Mb PubMedsearch
Wikidata
View/Edit Human View/Edit Mouse

Metabotropic glutamate receptor 8is aproteinthat in humans is encoded by theGRM8gene.

Function

L-glutamateis the majorexcitatory neurotransmitterin thecentral nervous systemand activates bothionotropicandmetabotropic glutamate receptors.Glutamatergicneurotransmission is involved in most aspects of normal brain function and can be perturbed in manyneuropathologicconditions. The metabotropic glutamate receptors are a family ofG protein-coupled receptors,that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includesGRM1andGRM5and these receptors have been shown to activate phospholipase C. Group II includesGRM2andGRM3while Group III includesGRM4,GRM6,GRM7and GRM8. Group II and III receptors are linked to the inhibition of thecyclic AMPcascade but differ in their agonist selectivities. Alternativesplice variantsof GRM8 have been described but their full-length nature has not been determined.

Ligands

• (S)-3,4-DCPG:agonist
• AZ12216052:positive allosteric modulator

See also

• Metabotropic glutamate receptor

Further reading

• Scherer SW, Soder S, Duvoisin RM, Huizenga JJ, Tsui LC (September 1997)."The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1".Genomics.44(2): 232–236.doi:10.1006/geno.1997.4842.PMID9299241.
• Wu S, Wright RA, Rockey PK, Burgett SG, Arnold JS, Rosteck PR, et al. (January 1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells".Brain Research. Molecular Brain Research.53(1–2): 88–97.doi:10.1016/S0169-328X(97)00277-5.PMID9473604.
• Malherbe P, Kratzeisen C, Lundstrom K, Richards JG, Faull RL, Mutel V (April 1999). "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8".Brain Research. Molecular Brain Research.67(2): 201–210.doi:10.1016/S0169-328X(99)00050-9.PMID10216218.
• Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (March 2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord".Neuropharmacology.40(3): 311–318.doi:10.1016/S0028-3908(00)00169-6.PMID11166323.S2CID2872874.
• Enz R (March 2002)."The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7".FEBS Letters.514(2–3): 184–188.doi:10.1016/S0014-5793(02)02361-X.PMID11943148.S2CID44474808.
• Tang Z, El Far O, Betz H, Scheschonka A (November 2005)."Pias1 interaction and sumoylation of metabotropic glutamate receptor 8".The Journal of Biological Chemistry.280(46): 38153–38159.doi:10.1074/jbc.M508168200.PMID16144832.
• Kobayashi Y, Akiyoshi J, Kanehisa M, Ichioka S, Tanaka Y, Tsuru J, et al. (February 2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder".Psychiatric Genetics.17(1): 9.doi:10.1097/YPG.0b013e32801118bc.PMID17167337.

This article incorporates text from theUnited States National Library of Medicine,which is in thepublic domain.