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Cardiac muscle

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Cardiac muscle
Details
Part ofTheheart wall
Identifiers
Latintextus muscularis striatus cardiacus
MeSHD009206
TA98A12.1.06.001
TA23950
FMA9462
Anatomical terminology

Cardiac muscle(also calledheart muscleormyocardium) is one of three types ofvertebratemuscle tissues,the others beingskeletal muscleandsmooth muscle.It is an involuntary,striated musclethat constitutes the main tissue of thewall of the heart.The cardiac muscle (myocardium) forms a thick middle layer between the outer layer of the heart wall (thepericardium) and the inner layer (theendocardium), with blood supplied via thecoronary circulation.It is composed of individual cardiac muscle cells joined byintercalated discs,and encased bycollagen fibersand other substances that form theextracellular matrix.

Cardiac musclecontractsin a similar manner toskeletal muscle,although with some important differences. Electrical stimulation in the form of acardiac action potentialtriggers the release of calcium from the cell's internal calcium store, thesarcoplasmic reticulum.The rise in calcium causes the cell'smyofilamentsto slide past each other in a process calledexcitation-contraction coupling. Diseases of the heart muscle known ascardiomyopathiesare of major importance. These includeischemicconditions caused by a restricted blood supply to the muscle such asangina,andmyocardial infarction.

Structure

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Gross anatomy

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Further information:Heart § Structure
3D rendering showing thick myocardium within the heart wall.
Differently oriented cardiac muscle fibers.
Cardiac muscle
Cardiac sarcomere structure

Cardiac muscle tissue or myocardium forms the bulk of the heart. The heart wall is a three-layered structure with a thick layer of myocardium sandwiched between the innerendocardiumand the outerepicardium(also known as the visceral pericardium). The inner endocardium lines the cardiac chambers, covers thecardiac valves,and joins with theendotheliumthat lines the blood vessels that connect to the heart. On the outer aspect of the myocardium is theepicardiumwhich forms part of thepericardial sacthat surrounds, protects, and lubricates the heart.[1]

Within the myocardium, there are several sheets of cardiac muscle cells or cardiomyocytes. The sheets of muscle that wrap around the left ventricle closest to the endocardium are oriented perpendicularly to those closest to the epicardium. When these sheets contract in a coordinated manner they allow the ventricle to squeeze in several directions simultaneously – longitudinally (becoming shorter from apex to base), radially (becoming narrower from side to side), and with a twisting motion (similar to wringing out a damp cloth) to squeeze the maximum possible amount of blood out of the heart with each heartbeat.[2]

Contracting heart muscle uses a lot of energy, and therefore requires a constant flow of blood to provideoxygenand nutrients.Bloodis brought to the myocardium by thecoronary arteries.These originate from theaortic rootand lie on the outer or epicardial surface of the heart. Blood is then drained away by thecoronary veinsinto theright atrium.[1]

Microanatomy

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Illustration of a cardiac muscle cell.
An isolated cardiac muscle cell, beating

Cardiac muscle cells(also calledcardiomyocytes) are the contractilemyocytesof the cardiac muscle. The cells are surrounded by anextracellular matrixproduced by supportingfibroblastcells. Specialised modified cardiomyocytes known aspacemaker cells,set the rhythm of the heart contractions. The pacemaker cells are only weakly contractile without sarcomeres, and are connected to neighboring contractile cells viagap junctions.[3]They are located in thesinoatrial node(the primary pacemaker) positioned on the wall of theright atrium,near the entrance of thesuperior vena cava.[4]Other pacemaker cells are found in the atrioventricular node (secondary pacemaker).

Pacemaker cells carry the impulses that are responsible for the beating of the heart. They are distributed throughout the heart and are responsible for several functions. First, they are responsible for being able tospontaneously generateand send outelectrical impulses.They also must be able to receive and respond to electrical impulses from the brain. Lastly, they must be able to transfer electrical impulses from cell to cell.[5]Pacemaker cells in the sinoatrial node, and atrioventricular node are smaller and conduct at a relatively slow rate between the cells. Specialized conductive cells in thebundle of His,and thePurkinje fibersare larger in diameter and conduct signals at a fast rate.[6]

The Purkinje fibers rapidly conduct electrical signals;coronary arteriesto bring nutrients to the muscle cells, andveinsand acapillarynetwork to take away waste products.[7]

Cardiac muscle cells are the contracting cells that allow the heart to pump. Each cardiomyocyte needs to contract in coordination with its neighboring cells - known as afunctional syncytium- working to efficiently pump blood from the heart, and if this coordination breaks down then – despite individual cells contracting – the heart may not pump at all, such as may occur duringabnormal heart rhythmssuch asventricular fibrillation.[8]

Viewed through a microscope, cardiac muscle cells are roughly rectangular, measuring 100–150μm by 30–40μm.[9]Individual cardiac muscle cells are joined at their ends byintercalated discsto form long fibers. Each cell containsmyofibrils,specialized protein contractile fibers ofactinandmyosinthat slide past each other. These are organized intosarcomeres,the fundamental contractile units of muscle cells. The regular organization of myofibrils into sarcomeres gives cardiac muscle cells a striped orstriatedappearance when looked at through a microscope, similar to skeletal muscle. These striations are caused by lighterI bandscomposed mainly of actin, and darkerA bandscomposed mainly of myosin.[7]

Cardiomyocytes containT-tubules,pouches ofcell membranethat run from the cell surface to the cell's interior which help to improve the efficiency of contraction. The majority of these cells contain only onenucleus(some may have two central nuclei), unlike skeletal muscle cells which containmany nuclei.Cardiac muscle cells contain manymitochondriawhich provide the energy needed for the cell in the form ofadenosine triphosphate(ATP), making them highly resistant to fatigue.[9][7]

T-tubules

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Main article:T-tubules

T-tubulesare microscopic tubes that run from the cell surface to deep within the cell. They are continuous with the cell membrane, are composed of the samephospholipid bilayer,and are open at the cell surface to theextracellular fluidthat surrounds the cell. T-tubules in cardiac muscle are bigger and wider than those inskeletal muscle,but fewer in number.[9]In the centre of the cell they join, running into and along the cell as a transverse-axial network. Inside the cell they lie close to the cell's internal calcium store, thesarcoplasmic reticulum.Here, a single tubule pairs with part of the sarcoplasmic reticulum called a terminal cisterna in a combination known as adiad.[10]

The functions of T-tubules include rapidly transmitting electrical impulses known asaction potentialsfrom the cell surface to the cell's core, and helping to regulate the concentration of calcium within the cell in a process known asexcitation-contraction coupling.[9]They are also involved in mechano-electric feedback,[11]as evident from cell contraction induced T-tubular content exchange (advection-assisted diffusion),[12]which was confirmed by confocal and 3D electron tomography observations.[13]

Intercalated discs

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Main article:Intercalated disc
Intercalated discsare part of the cardiac muscle cellsarcolemmaand they containgap junctionsanddesmosomes.

Thecardiac syncytiumis a network of cardiomyocytes connected byintercalated discsthat enable the rapid transmission of electrical impulses through the network, enabling the syncytium to act in a coordinated contraction of the myocardium. There is anatrial syncytiumand aventricular syncytiumthat are connected by cardiac connection fibres.[14]Electrical resistance through intercalated discs is very low, thus allowing free diffusion of ions. The ease of ion movement along cardiac muscle fibers axes is such that action potentials are able to travel from one cardiac muscle cell to the next, facing only slight resistance. Each syncytium obeys theall or none law.[15]

Intercalated discs are complex adhering structures that connect the single cardiomyocytes to an electrochemicalsyncytium(in contrast to the skeletal muscle, which becomes a multicellular syncytium duringembryonic development). The discs are responsible mainly for force transmission during muscle contraction. Intercalated discs consist of three different types of cell-cell junctions: the actin filament anchoringfascia adherens junctions,the intermediate filament anchoringdesmosomes,andgap junctions.[16]They allow action potentials to spread between cardiac cells by permitting the passage of ions between cells, producing depolarization of the heart muscle. The three types of junction act together as a singlearea composita.[16][17][18][19]

Underlight microscopy,intercalated discs appear as thin, typically dark-staining lines dividing adjacent cardiac muscle cells. The intercalated discs run perpendicular to the direction of muscle fibers. Under electron microscopy, an intercalated disc's path appears more complex. At low magnification, this may appear as a convoluted electron dense structure overlying the location of the obscured Z-line. At high magnification, the intercalated disc's path appears even more convoluted, with both longitudinal and transverse areas appearing in longitudinal section.[20]

Fibroblasts

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Main article:Fibroblasts

Cardiac fibroblasts are vital supporting cells within cardiac muscle. They are unable to provide forceful contractions likecardiomyocytes,but instead are largely responsible for creating and maintaining the extracellular matrix which surrounds the cardiomyocytes.[7]Fibroblasts play a crucial role in responding to injury, such as amyocardial infarction.Following injury, fibroblasts can become activated and turn intomyofibroblasts– cells which exhibit behaviour somewhere between a fibroblast (generating extracellular matrix) and asmooth muscle cell(ability to contract). In this capacity, fibroblasts can repair an injury by creating collagen while gently contracting to pull the edges of the injured area together.[21]

Fibroblasts are smaller but more numerous than cardiomyocytes, and several fibroblasts can be attached to a cardiomyocyte at once. When attached to a cardiomyocyte they can influence the electrical currents passing across the muscle cell's surface membrane, and in the context are referred to as being electrically coupled,[22]as originally shown in vitro in the 1960s,[23]and ultimately confirmed in native cardiac tissue with the help of optogenetic techniques.[24]Other potential roles for fibroblasts include electrical insulation of thecardiac conduction system,and the ability to transform into other cell types including cardiomyocytes andadipocytes.[21]

Extracellular matrix

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Main article:Extracellular matrix

Theextracellular matrix(ECM) surrounds the cardiomyocyte and fibroblasts. The ECM is composed of proteins includingcollagenandelastinalong withpolysaccharides(sugar chains) known asglycosaminoglycans.[7]Together, these substances give support and strength to the muscle cells, create elasticity in cardiac muscle, and keep the muscle cells hydrated by binding water molecules.

The matrix in immediate contact with the muscle cells is referred to as thebasement membrane,mainly composed oftype IV collagenandlaminin.Cardiomyocytes are linked to the basement membrane via specialisedglycoproteinscalledintegrins.[25]

Development

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Humans are born with a set number of heart muscle cells, or cardiomyocytes, which increase in size as the heart grows larger during childhood development. Evidence suggests that cardiomyocytes are slowly turned over during aging, but less than 50% of the cardiomyocytes present at birth are replaced during a normal life span.[26]The growth of individual cardiomyocytes not only occurs during normal heart development, it also occurs in response to extensive exercise (athletic heart syndrome), heart disease, or heart muscle injury such as after a myocardial infarction. A healthy adult cardiomyocyte has a cylindrical shape that is approximately 100μm long and 10–25μm in diameter. Cardiomyocyte hypertrophy occurs through sarcomerogenesis, the creation of new sarcomere units in the cell. During heart volume overload, cardiomyocytes grow through eccentric hypertrophy.[27]The cardiomyocytes extend lengthwise but have the same diameter, resulting in ventricular dilation. During heart pressure overload, cardiomyocytes grow through concentric hypertrophy.[27]The cardiomyocytes grow larger in diameter but have the same length, resulting in heart wall thickening.

Physiology

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Main article:Cardiac excitation-contraction coupling
Further information:AutorhythmicityandMyocardial contractility

The physiology of cardiac muscle shares many similarities with that ofskeletal muscle.The primary function of both muscle types is to contract, and in both cases, a contraction begins with a characteristic flow ofionsacross thecell membraneknown as anaction potential.Thecardiac action potentialsubsequently triggers muscle contraction by increasing the concentration ofcalciumwithin the cytosol.

Cardiac cycle

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Thecardiac cycleis the performance of the human heart from the beginning of one heartbeat to the beginning of the next. It consists of two periods: one during which the heart muscle relaxes and refills with blood, calleddiastole,following a period of robust contraction and pumping of blood, dubbedsystole.After emptying, the heart immediately relaxes and expands to receive another influx of blood returning from the lungs and other systems of the body, before again contracting to pump blood to the lungs and those systems. A normally performing heart must be fully expanded before it can efficiently pump again.

The rest phase is considered polarized. Theresting potentialduring this phase of the beat separates the ions such as sodium, potassium, and calcium. Myocardial cells possess the property of automaticity or spontaneousdepolarization.This is the direct result of a membrane which allows sodium ions to slowly enter the cell until the threshold is reached for depolarization. Calcium ions follow and extend the depolarization even further. Once calcium stops moving inward, potassium ions move out slowly to produce repolarization. The very slow repolarization of the CMC membrane is responsible for the long refractory period.[28][29]

However, the mechanism by which calcium concentrations within the cytosol rise differ between skeletal and cardiac muscle. In cardiac muscle, the action potential comprises an inward flow of both sodium and calcium ions. The flow of sodium ions is rapid but very short-lived, while the flow of calcium is sustained and gives the plateau phase characteristic of cardiac muscle action potentials. The comparatively small flow of calcium through theL-type calcium channelstriggers a much larger release of calcium from the sarcoplasmic reticulum in a phenomenon known ascalcium-induced calcium release.In contrast, in skeletal muscle, minimal calcium flows into the cell during action potential and instead the sarcoplasmic reticulum in these cells is directly coupled to the surface membrane. This difference can be illustrated by the observation that cardiac muscle fibers require calcium to be present in the solution surrounding the cell to contract, while skeletal muscle fibers will contract without extracellular calcium.

During contraction of a cardiac muscle cell, the long proteinmyofilamentsoriented along the length of the cell slide over each other in what is known as thesliding filament theory.There are two kinds of myofilaments, thick filaments composed of the proteinmyosin,and thin filaments composed of the proteinsactin,troponinandtropomyosin.As the thick and thin filaments slide past each other the cell becomes shorter and fatter. In a mechanism known ascross-bridge cycling,calcium ions bind to the protein troponin, which along with tropomyosin then uncover key binding sites on actin. Myosin, in the thick filament, can then bind to actin, pulling the thick filaments along the thin filaments. When the concentration of calcium within the cell falls, troponin and tropomyosin once again cover the binding sites on actin, causing the cell to relax.

Regeneration

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Dog cardiac muscle (400X)

It was commonly believed that cardiac muscle cells could not be regenerated. However, this was contradicted by a report published in 2009.[30]Olaf Bergmann and his colleagues at theKarolinska InstituteinStockholmtested samples of heart muscle from people born before 1955 who had very little cardiac muscle around their heart, many showing with disabilities from this abnormality. By using DNA samples from many hearts, the researchers estimated that a 4-year-old renews about 20% of heart muscle cells per year, and about 69% of the heart muscle cells of a 50-year-old were generated after they were born.[30]

One way that cardiomyocyte regeneration occurs is through the division of pre-existing cardiomyocytes during the normal aging process.[31]

In the 2000s, the discovery of adult endogenous cardiac stem cells was reported, and studies were published that claimed that various stem cell lineages, includingbone marrow stem cellswere able to differentiate into cardiomyocytes, and could be used to treatheart failure.[32][33] However, other teams were unable to replicate these findings, and many of the original studies were laterretractedfor scientific fraud.[34][35]

Differences between atria and ventricles

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The swirling musculature of the heart ensures effective pumping of blood.

Cardiac muscle forms both the atria and the ventricles of the heart. Although this muscle tissue is very similar between cardiac chambers, some differences exist. The myocardium found in the ventricles is thick to allow forceful contractions, while the myocardium in the atria is much thinner. The individual myocytes that make up the myocardium also differ between cardiac chambers. Ventricular cardiomyocytes are longer and wider, with a denserT-tubulenetwork. Although the fundamental mechanisms of calcium handling are similar between ventricular and atrial cardiomyocytes, the calcium transient is smaller and decays more rapidly in atrial myocytes, with a corresponding increase incalcium bufferingcapacity.[36]The complement of ion channels differs between chambers, leading to longer action potential durations and effective refractory periods in the ventricles. Certain ion currents such asIK(UR)are highly specific to atrial cardiomyocytes, making them a potential target for treatments foratrial fibrillation.[37]

Clinical significance

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Further information:Cardiomyopathy

Diseases affecting cardiac muscle, known ascardiomyopathies,are the leading cause of death indeveloped countries.[38]The most common condition iscoronary artery disease,in which theblood supply to the heart is reduced.Thecoronary arteriesbecome narrowed bythe formation of atherosclerotic plaques.[39]If these narrowings become severe enough to partially restrict blood flow, the syndrome ofanginapectoris may occur.[39]This typically causes chest pain during exertion that is relieved by rest. If a coronary artery suddenly becomes very narrowed or completely blocked, interrupting or severely reducing blood flow through the vessel, amyocardial infarctionor heart attack occurs.[40]If the blockage is not relieved promptly bymedication,percutaneous coronary intervention,orsurgery,then a heart muscle region may become permanently scarred and damaged.[41]Specific cardiomyopathies include: increasedleft ventricular mass(hypertrophic cardiomyopathy),[42]abnormally large (dilated cardiomyopathy),[43]or abnormally stiff (restrictive cardiomyopathy).[44]Some of these conditions are caused by genetic mutations and can be inherited.[45]

Heart muscle can also become damaged despite a normal blood supply. The heart muscle may become inflamed in a condition calledmyocarditis,[46]most commonly caused by a viral infection[47]but sometimes caused by the body's ownimmune system.[48]Heart muscle can also be damaged by drugs such as alcohol, long standing high blood pressure orhypertension,or persistent abnormalheart racing.[49] Many of these conditions, if severe enough, can damage the heart so much that the pumping function of the heart is reduced. If the heart is no longer able to pump enough blood to meet the body's needs, this is described asheart failure.[49]

Significant damage to cardiac muscle cells is referred to asmyocytolysiswhich is considered a type of cellularnecrosisdefined as either coagulative or colliquative.[50][51]

See also

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Wikimedia Commons has media related toMyocardium.
This article usesanatomical terminology.

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